Systematic generation of in vivo G protein-coupled receptor mutants in the rat

Pharmacogenomics Journal

Volumn 11, Issue 5, 2011, Pages 326-336

  Van Boxtel, R ^a   Vroling, B ^b   Toonen, P ^a   Nijman, I J ^a   Van Roekel, H ^b   Verheul, M ^a   Baakman, C ^b   Guryev, V ^a   Vriend, G ^b   Cuppen, E ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

allelic series; G protein coupled receptor; rat knockout

Indexed keywords

ETHYLNITROSOUREA; G PROTEIN COUPLED RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; EMBRYO; FEMALE; GENE MUTATION; GENOTYPE; HYDROPHOBICITY; IN VIVO STUDY; KNOCKOUT GENE; LIGAND BINDING; MALE; MISSENSE MUTATION; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; NONSENSE MUTATION; OPEN READING FRAME; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; STOP CODON;

ALLELES; ANIMALS; DISEASE; ETHYLNITROSOUREA; GENE EXPRESSION; GENE KNOCKOUT TECHNIQUES; GENETIC VARIATION; HUMANS; MUTAGENESIS; MUTATION; MUTATION, MISSENSE; PHENOTYPE; RATS; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHATIDIC ACID;

RATTUS;

EID: 78049352466     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2010.44     Document Type: Article

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