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1
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79953647671
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The gut microbiome as therapeutic target
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doi:10.1016/J.PHARMTHERA.2011.01.012
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Cani PD, Delzenne NM: The gut microbiome as therapeutic target. Pharmacol Ther 2011. doi:10.1016/J.PHARMTHERA.2011.01.012
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(2011)
Pharmacol Ther
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Cani, P.D.1
Delzenne, N.M.2
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2
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38849190556
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Gut microbiota: A potential new territory for drug targeting
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DOI 10.1038/nrd2505, PII NRD2505
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Jia W, Li H, Zhao L, Nicholson JK. Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov. 2008;7:123-9. (Pubitemid 351194060)
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Nature Reviews Drug Discovery
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Jia, W.1
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Zhao, L.3
Nicholson, J.K.4
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3
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76049118446
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Coordinated regulation of the metabolome and lipidome at the host-microbial interface
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This paper reviews the collected data related to the metabolomic approach to evaluate microbialhost interactions
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Backhed F, Crawford PA. Coordinated regulation of the metabolome and lipidome at the host-microbial interface. Biochim Biophys Acta. 2010;1801:240-5. This paper reviews the collected data related to the metabolomic approach to evaluate microbialhost interactions.
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Biochim Biophys Acta
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Backhed, F.1
Crawford, P.A.2
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4
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Genotype is a stronger determinant than sex of the mouse gut microbiota
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Kovacs A, Ben-Jacob N, Tayem H, et al. Genotype is a stronger determinant than sex of the mouse gut microbiota. Microb Ecol. 2011;61:423-8.
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Microb Ecol
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Kovacs, A.1
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Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol. 2010;26:5-11.
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Ley, R.E.1
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Interplay between obesity and associated metabolic disorders: New insights into the gut microbiota
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Cani PD, Delzenne NM. Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol. 2009;9:737-43.
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Curr Opin Pharmacol
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Cani, P.D.1
Delzenne, N.M.2
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7
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The gut microbiota as an environmental factor that regulates fat storage
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Backhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA. 2004;101:15718-23. (Pubitemid 39473554)
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Backhed, F.1
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Nagy, A.6
Semenkovich, C.F.7
Gordon, J.I.8
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8
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33846542071
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Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
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DOI 10.1073/pnas.0605374104
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Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice 1. Proc Natl Acad Sci USA. 2007;104:979-84. (Pubitemid 46154722)
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Proceedings of the National Academy of Sciences of the United States of America
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Backhed, F.1
Manchester, J.K.2
Semenkovich, C.F.3
Gordon, J.I.4
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9
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79955919136
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Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
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Diamant M, Blaak EE, de Vos WM: Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Obes Rev 2010.
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(2010)
Obes Rev
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Diamant, M.1
Blaak, E.E.2
De Vos, W.M.3
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10
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78649741587
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Germ-free C57BL/6 J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism
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Rabot S, Membrez M, Bruneau A, et al. Germ-free C57BL/6 J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J. 2010;24:4948-59.
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FASEB J
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Rabot, S.1
Membrez, M.2
Bruneau, A.3
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11
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77957262599
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Absence of intestinal microbiota does not protect mice from diet-induced obesity
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Fleissner CK, Huebel N, Abd El-Bary MM, et al. Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br J Nutr. 2010;104:919-29.
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Br J Nutr
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Fleissner, C.K.1
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Abd El-Bary, M.M.3
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12
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77950250064
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Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
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This is one of the key papers showing the transferability of the diabetic phenotype by inoculation of the gut microbiota to germ-free mice
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Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science. 2010;328:228-31. This is one of the key papers showing the transferability of the diabetic phenotype by inoculation of the gut microbiota to germ-free mice.
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Science
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Vijay-Kumar, M.1
Aitken, J.D.2
Carvalho, F.A.3
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13
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75349107762
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Nutritional modulation of gut microbiota in the context of obesity and insulin resistance: Potential interest of prebiotics
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Delzenne NM, Cani PD. Nutritional modulation of gut microbiota in the context of obesity and insulin resistance: Potential interest of prebiotics. Int Dairy J. 2010;20:277-80.
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Int Dairy J
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Delzenne, N.M.1
Cani, P.D.2
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14
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48249125862
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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
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Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57:1470-81.
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Diabetes
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Cani, P.D.1
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15
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34347399563
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Metabolic endotoxemia initiates obesity and insulin resistance
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DOI 10.2337/db06-1491
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Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761-72. (Pubitemid 47025442)
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Diabetes
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Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
Bastelica, D.6
Neyrinck, A.M.7
Fava, F.8
Tuohy, K.M.9
Chabo, C.10
Waget, A.11
Delmee, E.12
Cousin, B.13
Sulpice, T.14
Chamontin, B.15
Ferrieres, J.16
Tanti, J.-F.17
Gibson, G.R.18
Casteilla, L.19
Delzenne, N.M.20
Alessi, M.C.21
Burcelin, R.22
more..
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16
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33750584214
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TLR4 links innate immunity and fatty acid-induced insulin resistance
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DOI 10.1172/JCI28898
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Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015-25. (Pubitemid 44684486)
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Journal of Clinical Investigation
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Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
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17
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79952006811
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Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation
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Silver Spring This is interesting data relating the inflammation status and microbial changes upon pregnancy and fat mass development
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Basu S, Haghiac M, Surace P, et al. Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation. Obesity (Silver Spring). 2011;19:476-82. This is interesting data relating the inflammation status and microbial changes upon pregnancy and fat mass development.
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(2011)
Obesity
, vol.19
, pp. 476-482
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Basu, S.1
Haghiac, M.2
Surace, P.3
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18
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33947182436
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Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes
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Creely SJ, McTernan PG, Kusminski CM, et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab. 2007;292:E740-7.
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Am J Physiol Endocrinol Metab
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Creely, S.J.1
McTernan, P.G.2
Kusminski, C.M.3
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19
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79551656875
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A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese
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Sun L, Yu Z, Ye X, et al. A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diab Care. 2010;33:1925-32.
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Diab Care
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Sun, L.1
Yu, Z.2
Ye, X.3
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20
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34848912627
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Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
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DOI 10.1007/s00125-007-0791-0
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Cani PD, Neyrinck AM, Fava F, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia. 2007;50:2374-83. (Pubitemid 47512397)
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Diabetologia
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Cani, P.D.1
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Fava, F.3
Knauf, C.4
Burcelin, R.G.5
Tuohy, K.M.6
Gibson, G.R.7
Delzenne, N.M.8
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21
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43549107065
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Energy intake is associated with endotoxemia in apparently healthy men
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Amar J, Burcelin R, Ruidavets JB, et al. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr. 2008;87:1219-23. (Pubitemid 351679761)
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American Journal of Clinical Nutrition
, vol.87
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, pp. 1219-1223
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Amar, J.1
Burcelin, R.2
Ruidavets, J.B.3
Cani, P.D.4
Fauvel, J.5
Alessi, M.C.6
Chamontin, B.7
Ferrieres, J.8
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22
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72249106180
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Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: Implications for insulin resistance
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Ghanim H, Abuaysheh S, Sia CL, et al. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diab Care. 2009;32:2281-7.
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Diab Care
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Ghanim, H.1
Abuaysheh, S.2
Sia, C.L.3
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23
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36249005027
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A high-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation
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Erridge C, Attina T, Spickett CM, Webb DJ. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr. 2007;86:1286-92. (Pubitemid 350126229)
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American Journal of Clinical Nutrition
, vol.86
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Erridge, C.1
Attina, T.2
Spickett, C.M.3
Webb, D.J.4
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24
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65249099918
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Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
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Cani PD, Possemiers S, Van de WT, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009;58:1091-103.
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Gut
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Cani, P.D.1
Possemiers, S.2
Van De, W.T.3
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25
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77955153069
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The endocannabinoid system links gut microbiota to adipogenesis
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This is a paper describing the implication of the endocannabinoid system in the intestine and in the adipose tissue in the host response toward gut microbiota
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Muccioli GG, Naslain D, Backhed F, et al. The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol. 2010;6:392. This is a paper describing the implication of the endocannabinoid system in the intestine and in the adipose tissue in the host response toward gut microbiota.
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(2010)
Mol Syst Biol
, vol.6
, pp. 392
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Muccioli, G.G.1
Naslain, D.2
Backhed, F.3
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26
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77955595990
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Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation
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de La Serre CB, Ellis CL, Lee J, et al. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol. 2010;299:G440-8.
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Am J Physiol Gastrointest Liver Physiol
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De La Serre, C.B.1
Ellis, C.L.2
Lee, J.3
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27
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0038491435
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Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
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DOI 10.1074/jbc.M301403200
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Le PE, Loison C, Struyf S, et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation 1. J Biol Chem. 2003;278:25481-9. (Pubitemid 36835299)
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Journal of Biological Chemistry
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Le, P.E.1
Loison, C.2
Struyf, S.3
Springael, J.-Y.4
Lannoy, V.5
Decobecq, M.-E.6
Brezillon, S.7
Dupriez, V.8
Vassart, G.9
Van Damme, J.10
Parmentier, M.11
Detheux, M.12
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28
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Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
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Samuel BS, Shaito A, Motoike T, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci USA. 2008;105:16767-72.
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Proc Natl Acad Sci USA
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Samuel, B.S.1
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Motoike, T.3
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Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43
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DOI 10.1210/en.2005-0545
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Hong YH, Nishimura Y, Hishikawa D, et al. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology. 2005;146:5092-9. (Pubitemid 41653022)
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Endocrinology
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Hong, Y.-H.1
Nishimura, Y.2
Hishikawa, D.3
Tsuzuki, H.4
Miyahara, H.5
Gotoh, C.6
Choi, K.-C.7
Feng, D.D.8
Chen, C.9
Lee, H.-G.10
Katoh, K.11
Roh, S.-G.12
Sasaki, S.13
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30
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78650179808
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Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms
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This is a complete review of the state of the art concerning the metabolic regulation by propionate
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Al-Lahham SH, Peppelenbosch MP, Roelofsen H, et al. Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochim Biophys Acta. 2010;1801:1175-83. This is a complete review of the state of the art concerning the metabolic regulation by propionate.
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Biochim Biophys Acta
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Al-Lahham, S.H.1
Peppelenbosch, M.P.2
Roelofsen, H.3
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31
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67649238355
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Butyrate improves insulin sensitivity and increases energy expenditure in mice
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Gao Z, Yin J, Zhang J, et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes. 2009;58:1509-17.
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Gao, Z.1
Yin, J.2
Zhang, J.3
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Potential interest of gut microbial changes induced by non-digestible carbohydrates of wheat in the management of obesity and related disorders
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Neyrinck AM, Delzenne NM. Potential interest of gut microbial changes induced by non-digestible carbohydrates of wheat in the management of obesity and related disorders. Curr Opin Clin Nutr Metab Care. 2010;13:722-8.
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Curr Opin Clin Nutr Metab Care
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Delzenne, N.M.2
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Obesity alters gut microbial ecology
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DOI 10.1073/pnas.0504978102
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Ley RE, Backhed F, Turnbaugh P, et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA. 2005;102:11070-5. (Pubitemid 41105994)
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Proceedings of the National Academy of Sciences of the United States of America
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Ley, R.E.1
Backhed, F.2
Turnbaugh, P.3
Lozupone, C.A.4
Knight, R.D.5
Gordon, J.I.6
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34
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Human colonic microbiota associated with diet, obesity and weight loss
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Duncan SH, Lobley GE, Holtrop G, et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond). 2008;32:1720-4.
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Int J Obes
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Duncan, S.H.1
Lobley, G.E.2
Holtrop, G.3
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Human gut microbiota in obesity and after gastric bypass
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Zhang H, DiBaise JK, Zuccolo A, et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA. 2009;106:2365-70.
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Proc Natl Acad Sci USA
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Zhang, H.1
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Zuccolo, A.3
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36
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High-fat diet determines the composition of the murine gut microbiome independently of obesity
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Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology. 2009;137:1716-24.
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Gastroenterology
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Hildebrandt, M.A.1
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Composition and energy harvesting capacity of the gut microbiota: Relationship to diet, obesity and time in mouse models
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Murphy EF, Cotter PD, Healy S, et al. Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut. 2010;59:1635-42.
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Gut
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Murphy, E.F.1
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Early differences in fecal microbiota composition in children may predict overweight
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Kalliomaki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr. 2008;87:534-8. (Pubitemid 351364532)
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(2008)
American Journal of Clinical Nutrition
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Kalliomaki, M.1
Collado, M.C.2
Salminen, S.3
Isolauri, E.4
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39
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53849104768
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Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. 1
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Collado MC, Isolauri E, Laitinen K, Salminen S. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. 1. Am J Clin Nutr. 2008;88:894-9.
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Am J Clin Nutr
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Collado, M.C.1
Isolauri, E.2
Laitinen, K.3
Salminen, S.4
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40
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78650350690
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Bifidobacterium animalis AHC7 protects against pathogen-induced NF-kappaB activation in vivo
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O'Mahony D, Murphy S, Boileau T, et al. Bifidobacterium animalis AHC7 protects against pathogen-induced NF-kappaB activation in vivo. BMC Immunol. 2010;11:63.
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BMC Immunol
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O'Mahony, D.1
Murphy, S.2
Boileau, T.3
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41
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73949137604
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Microbiota and SCFA in lean and overweight healthy subjects
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Schwiertz A, Taras D, Schafer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obes Silver Spring. 2010;18:190-5.
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Obes Silver Spring
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Schwiertz, A.1
Taras, D.2
Schafer, K.3
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42
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78650944916
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Initial dietary and microbiological environments deviate in normal-weight compared to overweight children at 10 years of age
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This is interesting data supporting the relevance of the changes in microbiota early in life on the occurrence of overweight and obesity
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Luoto R, Kalliomaki M, Laitinen K, et al. Initial dietary and microbiological environments deviate in normal-weight compared to overweight children at 10 years of age. J Pediatr Gastroenterol Nutr. 2011;52:90-5. This is interesting data supporting the relevance of the changes in microbiota early in life on the occurrence of overweight and obesity.
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(2011)
J Pediatr Gastroenterol Nutr
, vol.52
, pp. 90-95
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Luoto, R.1
Kalliomaki, M.2
Laitinen, K.3
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43
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77954574372
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Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: A double-blind, placebo-controlled study
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Luoto R, Laitinen K, Nermes M, Isolauri E. Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr. 2010;103:1792-9.
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Br J Nutr
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Luoto, R.1
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Isolauri, E.4
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44
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78650037263
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Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: Links with metabolic and low-grade inflammation markers
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This is a key paper describing the relationship between the level of F. Prausnitzii in the fecal samples of obese humans, and the development of diabetes and inflammation
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