Bifidobacterium animalis AHC7 protects against pathogen-induced NF-κB activation in vivo

BMC Immunology

Volumn 11, Issue , 2010, Pages

  O'Mahony, David ^a   Murphy, Sharon ^a   Boileau, Thomas ^b   Park, JeanSoon ^b   O'Brien, Frances ^c   Groeger, David ^a   Konieczna, Patrycja ^d   Ziegler, Mario ^d   Scully, Paul ^c   Shanahan, Fergus ^c   Kiely, Barry ^a   O'Mahony, Liam ^d  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; MONOCLONAL ANTIBODY CD28; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; PROBIOTIC AGENT; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; FORKHEAD TRANSCRIPTION FACTOR; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIFIDOBACTERIUM ANIMALIS; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENTEROCOCCUS FAECIUM; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE CELL; LYMPHOCYTE COUNT; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PEYER PATCH; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; ACTIVE IMMUNIZATION; ANIMAL; BIFIDOBACTERIUM; BIOSYNTHESIS; DOG; GENETICS; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE ACTIVATION; METABOLISM; MICROBIOLOGY; MUCOSAL IMMUNITY; PATHOGENICITY; PATHOLOGY; REGULATORY T LYMPHOCYTE; TRANSCRIPTION INITIATION;

ANIMALS; BIFIDOBACTERIUM; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DOGS; ENTEROCOCCUS FAECIUM; FORKHEAD TRANSCRIPTION FACTORS; IMMUNITY, ACTIVE; IMMUNITY, MUCOSAL; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPH NODES; LYMPHOCYTE ACTIVATION; NF-KAPPA B; PEYER'S PATCHES; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTIONAL ACTIVATION;

EID: 78650350690     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-11-63     Document Type: Article

References (28)

1. Shanahan F. Gut microbes: from bugs to drugs. Am J Gastroenterol 2010, 105:275-279. 10.1038/ajg.2009.729, 20068561.
2. Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008, 4:337-349. 10.1016/j.chom.2008.09.009, 2597589, 18854238.
3. Sartor RB. Therapeutic correction of bacterial dysbiosis discovered by molecular techniques. Proc Natl Acad Sci USA 2008, 105:16413-16414. 10.1073/pnas.0809363105, 2575433, 18948599.
4. Rhee KJ, Wu S, Wu X, Huso DL, Karim B, Franco AA, Rabizadeh S, Golub JE, Mathews LE, Shin J, Sartor RB, Golenbock D, Hamad AR, Gan CM, Housseau F, Sears CL. Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect Immun 2009, 77:1708-1718. 10.1128/IAI.00814-08, 2663167, 19188353.
5. Lyons A, O'Mahony D, O'Brien F, Macsharry J, Sheil B, Ceddia M, Russell WM, Forsythe P, Bienenstock J, Kiely B, Shanahan F, O'Mahony L. Bacterial strain-specific induction of Foxp3(+) T regulatory cells is protective in murine allergy models. Clin Exp Allergy 2010, 40:811-9.
6. Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, Geuking MB, Beutler B, Tedder TF, Hardt WD, Bercik P, Verdu EF, McCoy KD, Macpherson AJ. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 2009, 325:617-620. 10.1126/science.1172747, 19644121.
7. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nature Immunol 2005, 6:353-360.
8. Collier-Hyams LS, Neish AS. Innate immune relationship between commensal flora and the mammalian intestinal epithelium. Cell Mol Life Sci 2005, 62:1339-1348. 10.1007/s00018-005-5038-y, 15971109.
9. Collier-Hyams LS, Zeng H, Sun J, Tomlinson AD, Bao ZQ, Chen H, Madara JL, Orth K, Neish AS. Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. J Immunol 2002, 169:2846-2850.
10. Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AG, Pettersson S, Conway S. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol 2004, 5:104-112. 10.1038/ni1018, 14691478.
11. O'Mahony C, Scully P, O'Mahony D, Murphy S, Lyons A, MacSharry J, Kiely B, Shanahan F, O'Mahony L. Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation. PLOS Pathogens 2008, 4:e1000112. 2474968, 18670628.
12. O'Mahony L, Feeney M, O'Halloran S, Murphy L, Kiely B, Fitzgibbon J, Lee G, O'Sullivan G, Shanahan F, Collins JK. Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther 2001, 15:1219-25.
13. McCarthy J, O'Mahony L, O'Callaghan L, Sheil B, Vaughan EE, Fitzsimons N, Fitzgibbon J, O'Sullivan GC, Kiely B, Collins JK, Shanahan F. Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut 2003, 52:975-980. 10.1136/gut.52.7.975, 1773705, 12801954.
14. Sheil B, McCarthy J, O'Mahony L, Bennett MW, Ryan P, Fitzgibbon JJ, Kiely B, Collins JK, Shanahan F. Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis. Gut 2004, 53:694-700. 10.1136/gut.2003.027789, 1774028, 15082588.
15. Grabig A, Paclik D, Guzy C, Dankof A, Baumgart DC, Erckenbrecht J, Raupach B, Sonnenborn U, Eckert J, Schumann RR, Wiedenmann B, Dignass AU, Sturm A. Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways. Infect Immun 2006, 74:4075-4082. 10.1128/IAI.01449-05, 1489743, 16790781.
16. Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008, 453:620-625. 10.1038/nature07008, 18509436.
17. Van der Kleij H, O'Mahony C, Shanahan F, O'Mahony L, Bienenstock J. Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve. Am J Physiol Regul Integr Comp Physiol 2008, 295:1131-1137.
18. Kelley RL, Minikhiem D, Kiely B, O'Mahony L, O'Sullivan D, Boileau T, Park JS. Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea. Vet Ther 2009, 10:121-130.
19. O'Mahony D, Murphy KB, MacSharry J, Boileau T, Sunvold G, Reinhart G, Kiely B, Shanahan F, O'Mahony L. Portrait of a canine probiotic Bifidobacterium--from gut to gut. Vet Microbiol 2009, 139:106-112.
20. Benyacoub J, Czarnecki-Maulden GL, Cavadini C, Sauthier T, Anderson RE, Schiffrin EJ, von der Weid T. Supplementation of food with Enterococcus faecium (SF68) stimulates immune functions in young dogs. J Nutr 2003, 133:1158-1162.
21. Benyacoub J, Pérez PF, Rochat F, Saudan KY, Reuteler G, Antille N, Humen M, De Antoni GL, Cavadini C, Blum S, Schiffrin EJ. Enterococcus faecium SF68 enhances the immune response to Giardia intestinalis in mice. J Nutr 2005, 135:1171-1176.
22. Grassl GA, Finlay BB. Pathogenesis of enteric Salmonella infections. Curr Opin Gastroenterol 2008, 24:22-26. 10.1097/MOG.0b013e3282f21388, 18043228.
23. Stecher B, Macpherson AJ, Hapfelmeier S, Kremer M, Stallmach T, Hardt WD. Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin. Infect Immun 2005, 73:3228-3241. 10.1128/IAI.73.6.3228-3241.2005, 1111827, 15908347.
24. Halle S, Bumann D, Herbrand H, Willer Y, Dahne S, Forster R, Pabst O. Solitary intestinal lymphoid tissue provides a productive port of entry for Salmonella enterica serovar Typhimurium. Infect Immun 2007, 75:1577-1585. 10.1128/IAI.01392-06, 1865728, 17283101.
25. Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol 2006, 7:868-874. 10.1038/ni1362, 16829963.
26. Hawiger J. Innate immunity and inflammation: a transcriptional paradigm. Immunol Res 2001, 23:99-109. 10.1385/IR:23:2-3:099, 11444396.
27. O'Mahony C, van der Kleij H, Bienenstock J, Shanahan F, O'Mahony L. Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer. Am J Physiol Regul Integr Comp Physiol 2009, 297:1118-1126.
28. Murphy C, Murphy S, O'Brien F, O'Donoghue M, Boileau T, Sunvold G, Reinhart G, Kiely B, Shanahan F, O'Mahony L. Metabolic activity of probiotics-oxalate degradation. Vet Microbiol 2009, 136:100-107. 10.1016/j.vetmic.2008.10.005, 19028028.