메뉴 건너뛰기




Volumn 6, Issue 3, 2010, Pages 362-374

Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits

Author keywords

Diabetes; Impaired glucose tolerance; Metabolomics; Pre diabetes; UPLC qTOF MS

Indexed keywords


EID: 77954457972     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-010-0203-1     Document Type: Article
Times cited : (182)

References (68)
  • 1
    • 33745325861 scopus 로고    scopus 로고
    • Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: Results from the Veterans Administration Genetic Epidemiology Study
    • Abdul-Ghani, M. A., Jenkinson, C. P., Richardson, D. K., Tripathy, D., & DeFronzo, R. A. (2006). Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: Results from the Veterans Administration Genetic Epidemiology Study. Diabetes, 55, 1430-1435.
    • (2006) Diabetes , vol.55 , pp. 1430-1435
    • Abdul-Ghani, M.A.1    Jenkinson, C.P.2    Richardson, D.K.3    Tripathy, D.4    Defronzo, R.A.5
  • 2
    • 34247637288 scopus 로고    scopus 로고
    • International Diabetes Federation: A consensus on Type 2 diabetes prevention
    • Alberti, K. G., Zimmet, P., & Shaw, J. (2007). International Diabetes Federation: A consensus on Type 2 diabetes prevention. Diabetic Medicine, 24, 451-463.
    • (2007) Diabetic Medicine , vol.24 , pp. 451-463
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 3
    • 70350560562 scopus 로고    scopus 로고
    • Metabolomics applied to diabetes research: Moving from information to knowledge
    • Bain, J. R., Stevens, R. D., Wenner, B. R., Ilkayeva, O., Muoio, D. M., & Newgard, C. B. (2009). Metabolomics applied to diabetes research: Moving from information to knowledge. Diabetes, 58, 2429-2443.
    • (2009) Diabetes , vol.58 , pp. 2429-2443
    • Bain, J.R.1    Stevens, R.D.2    Wenner, B.R.3    Ilkayeva, O.4    Muoio, D.M.5    Newgard, C.B.6
  • 4
  • 6
    • 0036913503 scopus 로고    scopus 로고
    • Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
    • Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W., et al. (2002). Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nature Medicine, 8, 1439-1444.
    • (2002) Nature Medicine , vol.8 , pp. 1439-1444
    • Brindle, J.T.1    Antti, H.2    Holmes, E.3    Tranter, G.4    Nicholson, J.K.5    Bethell, H.W.6
  • 7
    • 63249088847 scopus 로고    scopus 로고
    • Inflammation, insulin resistance, and type 2 diabetes: Back to the future?
    • Cefalu, W. T. (2009). Inflammation, insulin resistance, and type 2 diabetes: Back to the future? Diabetes, 58, 307-308.
    • (2009) Diabetes , vol.58 , pp. 307-308
    • Cefalu, W.T.1
  • 8
    • 39449129263 scopus 로고    scopus 로고
    • Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information
    • Chen, J., Zhao, X., Fritsche, J., Yin, P., Schmitt-Kopplin, P., Wang, W., et al. (2008). Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information. Analytical Chemistry, 80, 1280-1289.
    • (2008) Analytical Chemistry , vol.80 , pp. 1280-1289
    • Chen, J.1    Zhao, X.2    Fritsche, J.3    Yin, P.4    Schmitt-Kopplin, P.5    Wang, W.6
  • 9
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik, D. L., Cardozo, A. K., & Cnop, M. (2008). The role for endoplasmic reticulum stress in diabetes mellitus. Endocrine Reviews, 29, 42-61.
    • (2008) Endocrine Reviews , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 10
    • 77954456631 scopus 로고    scopus 로고
    • Eriksson, L., Johansson, E., Kettaneh-Wold, N., & Wold, S. (2001). Multi- and megavariate data analysis principals and applications Umetrics, Umea, Sweden.
  • 11
    • 2542556750 scopus 로고    scopus 로고
    • Differences in insulin resistance in nondiabetic subjects with isolated impaired glucose tolerance or isolated impaired fasting glucose
    • Festa, A., D'Agostino, R., Jr., Hanley, A. J., Karter, A. J., Saad, M. F., & Haffner, S. M. (2004). Differences in insulin resistance in nondiabetic subjects with isolated impaired glucose tolerance or isolated impaired fasting glucose. Diabetes, 53, 1549-1555.
    • (2004) Diabetes , vol.53 , pp. 1549-1555
    • Festa, A.1    D'Agostino Jr., R.2    Hanley, A.J.3    Karter, A.J.4    Saad, M.F.5    Haffner, S.M.6
  • 12
    • 52649149131 scopus 로고    scopus 로고
    • Multi-platform investigation of the metabolome in a leptin receptor defective murine model of type 2 diabetes
    • Gipson, G. T., Tatsuoka, K. S., Ball, R. J., Sokhansanj, B. A., Hansen, M. K., Ryan, T. E., et al. (2008). Multi-platform investigation of the metabolome in a leptin receptor defective murine model of type 2 diabetes. Molecular Biosystems, 4, 1015-1023.
    • (2008) Molecular Biosystems , vol.4 , pp. 1015-1023
    • Gipson, G.T.1    Tatsuoka, K.S.2    Ball, R.J.3    Sokhansanj, B.A.4    Hansen, M.K.5    Ryan, T.E.6
  • 13
    • 43749087841 scopus 로고    scopus 로고
    • Human metabolic phenotype diversity and its association with diet and blood pressure
    • Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K., Chan, Q., et al. (2008a). Human metabolic phenotype diversity and its association with diet and blood pressure. Nature, 453, 396-400.
    • (2008) Nature , vol.453 , pp. 396-400
    • Holmes, E.1    Loo, R.L.2    Stamler, J.3    Bictash, M.4    Yap, I.K.5    Chan, Q.6
  • 14
    • 50249099816 scopus 로고    scopus 로고
    • Metabolic phenotyping in health and disease
    • Holmes, E., Wilson, I. D., & Nicholson, J. K. (2008b). Metabolic phenotyping in health and disease. Cell, 134, 714-717.
    • (2008) Cell , vol.134 , pp. 714-717
    • Holmes, E.1    Wilson, I.D.2    Nicholson, J.K.3
  • 15
    • 62749130523 scopus 로고    scopus 로고
    • Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride
    • Huo, T., Cai, S., Lu, X., Sha, Y., Yu, M., & Li, F. (2009). Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride. Journal of Pharmaceutical and Biomedical Analysis, 49, 976-982.
    • (2009) Journal of Pharmaceutical and Biomedical Analysis , vol.49 , pp. 976-982
    • Huo, T.1    Cai, S.2    Lu, X.3    Sha, Y.4    Yu, M.5    Li, F.6
  • 16
    • 38849190556 scopus 로고    scopus 로고
    • Gut microbiota: A potential new territory for drug targeting
    • Jia, W., Li, H., Zhao, L., & Nicholson, J. K. (2008). Gut microbiota: A potential new territory for drug targeting. Nature Reviews Drug Discovery, 7, 123-129.
    • (2008) Nature Reviews Drug Discovery , vol.7 , pp. 123-129
    • Jia, W.1    Li, H.2    Zhao, L.3    Nicholson, J.K.4
  • 17
    • 33947216093 scopus 로고    scopus 로고
    • A comprehensive urinary metabolomic approach for identifying kidney cancer
    • Kind, T., Tolstikov, V., Fiehn, O., & Weiss, R. H. (2007). A comprehensive urinary metabolomic approach for identifying kidney cancer. Analytical Biochemistry, 363, 185-195.
    • (2007) Analytical Biochemistry , vol.363 , pp. 185-195
    • Kind, T.1    Tolstikov, V.2    Fiehn, O.3    Weiss, R.H.4
  • 18
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
    • Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., et al. (2005). Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. The Journal of Biological Chemistry, 280, 33588-33598.
    • (2005) The Journal of Biological Chemistry , vol.280 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3    Akimoto, T.4    Slentz, D.5    Ilkayeva, O.6
  • 19
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., et al. (2008). Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metabolism, 7, 45-56.
    • (2008) Cell Metabolism , vol.7 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3    Slentz, D.4    Mosedale, M.5    Ilkayeva, O.6
  • 20
    • 7944220068 scopus 로고    scopus 로고
    • Metabonomics, dietary influences and cultural differences: A 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects
    • Lenz, E. M., Bright, J., Wilson, I. D., Hughes, A., Morrisson, J., Lindberg, H., et al. (2004). Metabonomics, dietary influences and cultural differences: A 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects. Journal of Pharmaceutical and Biomedical Analysis, 36, 841-849.
    • (2004) Journal of Pharmaceutical and Biomedical Analysis , vol.36 , pp. 841-849
    • Lenz, E.M.1    Bright, J.2    Wilson, I.D.3    Hughes, A.4    Morrisson, J.5    Lindberg, H.6
  • 22
    • 55849144043 scopus 로고    scopus 로고
    • Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury
    • Lewis, G. D., Wei, R., Liu, E., Yang, E., Shi, X., Martinovic, M., et al. (2008). Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. Journal of Clinical Investigation, 118, 3503-3512.
    • (2008) Journal of Clinical Investigation , vol.118 , pp. 3503-3512
    • Lewis, G.D.1    Wei, R.2    Liu, E.3    Yang, E.4    Shi, X.5    Martinovic, M.6
  • 23
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006). Microbial ecology: Human gut microbes associated with obesity. Nature, 444, 1022-1023.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 26
  • 28
    • 47349099600 scopus 로고    scopus 로고
    • Insulin resistance: A proinflammatory state mediated by lipid-induced signaling dysfunction and involved in atherosclerotic plaque instability
    • Montecucco, F., Steffens, S., & Mach, F. (2008). Insulin resistance: a proinflammatory state mediated by lipid-induced signaling dysfunction and involved in atherosclerotic plaque instability. Mediators of Inflammation, 2008, 767623.
    • (2008) Mediators of Inflammation , vol.2008 , pp. 767623
    • Montecucco, F.1    Steffens, S.2    Mach, F.3
  • 30
    • 17844404232 scopus 로고    scopus 로고
    • Gut microorganisms, mammalian metabolism and personalized health care
    • Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005). Gut microorganisms, mammalian metabolism and personalized health care. Nature Reviews. Microbiology, 3, 431-438.
    • (2005) Nature Reviews. Microbiology , vol.3 , pp. 431-438
    • Nicholson, J.K.1    Holmes, E.2    Wilson, I.D.3
  • 31
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology: Metabonomics
    • Nicholson, J. K., & Lindon, J. C. (2008). Systems biology: Metabonomics. Nature, 455, 1054-1056.
    • (2008) Nature , vol.455 , pp. 1054-1056
    • Nicholson, J.K.1    Lindon, J.C.2
  • 32
    • 25644457634 scopus 로고    scopus 로고
    • Differences in cardiovascular risk factors, insulin resistance, and insulin secretion in individuals with normal glucose tolerance and in subjects with impaired glucose regulation: The Telde Study
    • Novoa, F. J., Boronat, M., Saavedra, P., Diaz-Cremades, J. M., Varillas, V. F., La Roche, F., et al. (2005). Differences in cardiovascular risk factors, insulin resistance, and insulin secretion in individuals with normal glucose tolerance and in subjects with impaired glucose regulation: The Telde Study. Diabetes Care, 28, 2388-2393.
    • (2005) Diabetes Care , vol.28 , pp. 2388-2393
    • Novoa, F.J.1    Boronat, M.2    Saavedra, P.3    Diaz-Cremades, J.M.4    Varillas, V.F.5    la Roche, F.6
  • 34
    • 14744285326 scopus 로고    scopus 로고
    • Impaired glucose tolerance and impaired fasting glucose-a review of diagnosis, clinical implications and management
    • Petersen, J. L., & McGuire, D. K. (2005). Impaired glucose tolerance and impaired fasting glucose-a review of diagnosis, clinical implications and management. Diabetes and Vascular Disease Research, 2, 9-15.
    • (2005) Diabetes and Vascular Disease Research , vol.2 , pp. 9-15
    • Petersen, J.L.1    McGuire, D.K.2
  • 35
    • 33749512402 scopus 로고    scopus 로고
    • The detection of phenotypic differences in the metabolic plasma profile of three strains of Zucker rats at 20 weeks of age using ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry
    • Plumb, R. S., Johnson, K. A., Rainville, P., Shockcor, J. P., Williams, R., Granger, J. H., et al. (2006). The detection of phenotypic differences in the metabolic plasma profile of three strains of Zucker rats at 20 weeks of age using ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, 20, 2800-2806.
    • (2006) Rapid Communications in Mass Spectrometry , vol.20 , pp. 2800-2806
    • Plumb, R.S.1    Johnson, K.A.2    Rainville, P.3    Shockcor, J.P.4    Williams, R.5    Granger, J.H.6
  • 38
    • 49449083937 scopus 로고    scopus 로고
    • Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
    • Shaham, O., Wei, R., Wang, T. J., Ricciardi, C., Lewis, G. D., Vasan, R. S., et al. (2008). Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Molecular Systems Biology, 4, 214.
    • (2008) Molecular Systems Biology , vol.4 , pp. 214
    • Shaham, O.1    Wei, R.2    Wang, T.J.3    Ricciardi, C.4    Lewis, G.D.5    Vasan, R.S.6
  • 40
    • 29544452318 scopus 로고    scopus 로고
    • The relation of fasting and 2-h postchallenge plasma glucose concentrations to mortality: Data from the Baltimore Longitudinal Study of Aging with a critical review of the literature
    • Sorkin, J. D., Muller, D. C., Fleg, J. L., & Andres, R. (2005). The relation of fasting and 2-h postchallenge plasma glucose concentrations to mortality: Data from the Baltimore Longitudinal Study of Aging with a critical review of the literature. Diabetes Care, 28, 2626-2632.
    • (2005) Diabetes Care , vol.28 , pp. 2626-2632
    • Sorkin, J.D.1    Muller, D.C.2    Fleg, J.L.3    Andres, R.4
  • 41
    • 60149091657 scopus 로고    scopus 로고
    • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    • Sreekumar, A., Poisson, L. M., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., et al. (2009). Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature, 457, 910-914.
    • (2009) Nature , vol.457 , pp. 910-914
    • Sreekumar, A.1    Poisson, L.M.2    Rajendiran, T.M.3    Khan, A.P.4    Cao, Q.5    Yu, J.6
  • 42
    • 9444249274 scopus 로고    scopus 로고
    • Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells
    • Staiger, H., Staiger, K., Stefan, N., Wahl, H. G., Machicao, F., Kellerer, M., et al. (2004). Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes, 53, 3209-3216.
    • (2004) Diabetes , vol.53 , pp. 3209-3216
    • Staiger, H.1    Staiger, K.2    Stefan, N.3    Wahl, H.G.4    Machicao, F.5    Kellerer, M.6
  • 43
    • 41149102818 scopus 로고    scopus 로고
    • Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans
    • Stefan, N., Peter, A., Cegan, A., Staiger, H., Machann, J., Schick, F., et al. (2008). Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia, 51, 648-656.
    • (2008) Diabetologia , vol.51 , pp. 648-656
    • Stefan, N.1    Peter, A.2    Cegan, A.3    Staiger, H.4    Machann, J.5    Schick, F.6
  • 46
    • 34547674398 scopus 로고    scopus 로고
    • Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice
    • Toye, A. A., Dumas, M. E., Blancher, C., Rothwell, A. R., Fearnside, J. F., Wilder, S. P., et al. (2007). Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice. Diabetologia, 50, 1867-1879.
    • (2007) Diabetologia , vol.50 , pp. 1867-1879
    • Toye, A.A.1    Dumas, M.E.2    Blancher, C.3    Rothwell, A.R.4    Fearnside, J.F.5    Wilder, S.P.6
  • 48
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006). An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 444, 1027-1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 49
    • 0036046668 scopus 로고    scopus 로고
    • Impaired glucose tolerance and impaired fasting glycaemia: The current status on definition and intervention
    • Unwin, N., Shaw, J., Zimmet, P., & Alberti, K. G. (2002). Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. Diabetic Medicine, 19, 708-723.
    • (2002) Diabetic Medicine , vol.19 , pp. 708-723
    • Unwin, N.1    Shaw, J.2    Zimmet, P.3    Alberti, K.G.4
  • 51
    • 34247397544 scopus 로고    scopus 로고
    • Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
    • van Doorn, M., Vogels, J., Tas, A., van Hoogdalem, E. J., Burggraaf, J., Cohen, A., et al. (2007). Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers. British Journal of Clinical Pharmacology, 63, 562-574.
    • (2007) British Journal of Clinical Pharmacology , vol.63 , pp. 562-574
    • van Doorn, M.1    Vogels, J.2    Tas, A.3    van Hoogdalem, E.J.4    Burggraaf, J.5    Cohen, A.6
  • 53
    • 21644479604 scopus 로고    scopus 로고
    • Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis
    • Wang, C., Kong, H., Guan, Y., Yang, J., Gu, J., Yang, S., et al. (2005). Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis. Analytical Chemistry, 77, 4108-4116.
    • (2005) Analytical Chemistry , vol.77 , pp. 4108-4116
    • Wang, C.1    Kong, H.2    Guan, Y.3    Yang, J.4    Gu, J.5    Yang, S.6
  • 55
    • 2642561229 scopus 로고    scopus 로고
    • Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
    • Weigert, C., Brodbeck, K., Staiger, H., Kausch, C., Machicao, F., Haring, H. U., et al. (2004). Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. The Journal of Biological Chemistry, 279, 23942-23952.
    • (2004) The Journal of Biological Chemistry , vol.279 , pp. 23942-23952
    • Weigert, C.1    Brodbeck, K.2    Staiger, H.3    Kausch, C.4    Machicao, F.5    Haring, H.U.6
  • 56
    • 77954460271 scopus 로고    scopus 로고
    • WHO. (2006). Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: Report of WHO/IDF consultation. WHO Press, Geneva.
  • 57
    • 41149120242 scopus 로고    scopus 로고
    • Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models
    • Wiklund, S., Johansson, E., Sjostrom, L., Mellerowicz, E. J., Edlund, U., Shockcor, J. P., et al. (2008). Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Analytical Chemistry, 80, 115-122.
    • (2008) Analytical Chemistry , vol.80 , pp. 115-122
    • Wiklund, S.1    Johansson, E.2    Sjostrom, L.3    Mellerowicz, E.J.4    Edlund, U.5    Shockcor, J.P.6
  • 58
    • 33644849267 scopus 로고    scopus 로고
    • The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats
    • Williams, R. E., Lenz, E. M., Rantalainen, M., & Wilson, I. D. (2006a). The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats. Molecualr Biosystems, 2, 193-202.
    • (2006) Molecualr Biosystems , vol.2 , pp. 193-202
    • Williams, R.E.1    Lenz, E.M.2    Rantalainen, M.3    Wilson, I.D.4
  • 59
    • 33644861299 scopus 로고    scopus 로고
    • A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats
    • Williams, R., Lenz, E. M., Wilson, A. J., Granger, J., Wilson, I. D., Major, H., et al. (2006b). A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats. Molecular Biosystems, 2, 174-183.
    • (2006) Molecular Biosystems , vol.2 , pp. 174-183
    • Williams, R.1    Lenz, E.M.2    Wilson, A.J.3    Granger, J.4    Wilson, I.D.5    Major, H.6
  • 61
    • 84939895432 scopus 로고    scopus 로고
    • Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes
    • Wopereis, S., Rubingh, C. M., van Erk, M. J., Verheij, E. R., van Vliet, T., Cnubben, N. H., et al. (2009). Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes. PLoS ONE, 4, e4525.
    • (2009) PLoS ONE , vol.4
    • Wopereis, S.1    Rubingh, C.M.2    van Erk, M.J.3    Verheij, E.R.4    van Vliet, T.5    Cnubben, N.H.6
  • 62
    • 77954458164 scopus 로고    scopus 로고
    • Yach, D., & Alberti, G. (2003). Screening for type 2 diabetes. Marketing and Dissemination, World Health Organization, Geneva.
  • 63
    • 0034020780 scopus 로고    scopus 로고
    • Glutamate, a window on liver intermediary metabolism
    • Yang, D., & Brunengraber, H. (2000). Glutamate, a window on liver intermediary metabolism. Journal of Nutrition, 130, 991S-994S.
    • (2000) Journal of Nutrition , vol.130
    • Yang, D.1    Brunengraber, H.2
  • 64
    • 48749106399 scopus 로고    scopus 로고
    • Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry
    • Yin, P., Mohemaiti, P., Chen, J., Zhao, X., Lu, X., Yimiti, A., et al. (2008). Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry. Journal of Chromatography B, 871, 322-327.
    • (2008) Journal of Chromatography B , vol.871 , pp. 322-327
    • Yin, P.1    Mohemaiti, P.2    Chen, J.3    Zhao, X.4    Lu, X.5    Yimiti, A.6
  • 65
    • 52049118795 scopus 로고    scopus 로고
    • Correlative and quantitative (1)H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats
    • Zhang, S., Nagana Gowda, G. A., Asiago, V., Shanaiah, N., Barbas, C., & Raftery, D. (2008). Correlative and quantitative (1)H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats. Analytical Biochemistry, 383, 76-84.
    • (2008) Analytical Biochemistry , vol.383 , pp. 76-84
    • Zhang, S.1    Nagana Gowda, G.A.2    Asiago, V.3    Shanaiah, N.4    Barbas, C.5    Raftery, D.6
  • 66
    • 70449450345 scopus 로고    scopus 로고
    • Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses
    • Zhang, X., Wang, Y., Hao, F., Zhou, X., Han, X., Tang, H., et al. (2009). Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses. Journal of Proteome Research, 8, 5188-5195.
    • (2009) Journal of Proteome Research , vol.8 , pp. 5188-5195
    • Zhang, X.1    Wang, Y.2    Hao, F.3    Zhou, X.4    Han, X.5    Tang, H.6
  • 68
    • 52149124125 scopus 로고    scopus 로고
    • Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry
    • Zhao, X., Zhang, Y., Meng, X., Yin, P., Deng, C., Chen, J., et al. (2008). Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry. Journal of Chromatography B, 873, 151-158.
    • (2008) Journal of Chromatography B , vol.873 , pp. 151-158
    • Zhao, X.1    Zhang, Y.2    Meng, X.3    Yin, P.4    Deng, C.5    Chen, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.