Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation

Journal of Molecular Neuroscience

Volumn 44, Issue 2, 2011, Pages 115-121

  Deng, Guang Fei ^a   Qin, Jia Ming ^a   Sun, Xun Sha ^a   Kuang, Zu Ying ^a   Su, Tao ^a   Zhao, Qi Hua ^a   Shi, Yi Wu ^a   Liu, Xiao Rong ^a   Yu, Mei Juan ^a   Yi, Yong Hong ^a   Liao, Wei Ping ^a   Long, Yue Sheng ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

CpG methylation; GC box; Promoter; Transcriptional regulation; Voltage gated sodium channel

Indexed keywords

CYTOSINE; GUANINE; LUCIFERASE; SODIUM CHANNEL NAV1.3;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE CONTROL; GENE EXPRESSION; GENETIC IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION;

ANIMALS; CELL LINE, TUMOR; CPG ISLANDS; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; GENE EXPRESSION REGULATION; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS, GENETIC; SODIUM CHANNELS;

EID: 79955894035     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-011-9492-8     Document Type: Article

References (42)

1. Beckh S, Noda M, Lubbert H, Numa S (1989) Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EMBO J 8:3611-3616 (Pubitemid 20016038)
2. Bird AP (1986) CpG-rich islands and the function of DNA methylation. Nature 321:209-213
3. Blake MC, Jambou RC, Swick AG, Kahn JW, Azizkhan JC (1990) Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter. Mol Cell Biol 10:6632-6641 (Pubitemid 120004608)
4. + channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. Neuroscientist 14:571-583
5. Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26:13-25
6. Catterall WA (2001) A 3D view of sodium channels. Nature 409:988-991
7. Chen C, Westenbroek RE, Xu X et al (2004) Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 24:4030-4042 (Pubitemid 38544229)
8. Clark SJ, Harrison J, Molloy PL (1997) Sp1 binding is inhibited by (m)Cp(m)CpG methylation. Gene 195:67-71 (Pubitemid 27336963)
9. Cross SH, Bird AP (1995) CpG islands and genes. Curr Opin Genet Dev 5:309-314
10. Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, Waxman SG (1999) A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J Neurosci 19:RC43
11. Drews VL, Lieberman AP, Meisler MH (2005) Multiple transcripts of sodium channel SCN8A (Na(V)1.6) with alternative 5′- and 3′- untranslated regions and initial characterization of the SCN8A promoter. Genomics 85:245-257 (Pubitemid 40164790)
12. Elango N, Yi SV (2008) DNA methylation and structural and functional bimodality of vertebrate promoters. Mol Biol Evol 25:1602-1608 (Pubitemid 352019845)
13. Garber SS, Hoshi T, Aldrich RW (1989) Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone. J Neurosci 9:3976-3987 (Pubitemid 20004892)
14. Gardiner-Garden M, Frommer M (1987) CpG islands in vertebrate genomes. J Mol Biol 196:261-282 (Pubitemid 17122132)
15. Goldin AL (2001) Resurgence of sodium channel research. Annu Rev Physiol 63:871-894
16. Gunning PW, Landreth GE, Layer P, Ignatius M, Shooter EM (1981) Nerve growth factor-induced differentiation of PC12 cells: evaluation of changes in RNA and DNA metabolism. J Neurosci 1:368-379 (Pubitemid 11053809)
17. Guo F, Yu N, Cai JQ et al (2008) Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat. Brain Res Bull 75:179-187
18. Harrington MA, Jones PA, Imagawa M, Karin M (1988) Cytosine methylation does not affect binding of transcription factor Sp1. Proc Natl Acad Sci USA 85:2066-2070 (Pubitemid 24315829)
19. Hata K, Sakaki Y (1997) Identification of critical CpG sites for repression of L1 transcription by DNA methylation. Gene 189:227-234 (Pubitemid 27187196)
20. Jones PA, Takai D (2001) The role of DNA methylation in mammalian epigenetics. Science 293:1068-1070 (Pubitemid 32758075)
21. Li R, Kong Y, Ladisch S (1998) Nerve growth factor-induced neurite formation in PC12 cells is independent of endogenous cellular gangliosides. Glycobiology 8:597-603 (Pubitemid 28270581)
22. Li D, Da L, Tang H, Li T, Zhao M (2008) CpG methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing DFF45-like effector A gene through the regulation of Sp1/Sp3 binding. Nucleic Acids Res 36:330-341
23. Long YS, Zhao QH, Su T et al (2008) Identification of the promoter region and the 5′-untranslated exons of the human voltage-gated sodium channel Na(v)1.1 gene (SCN1A) and enhancement of gene expression by the 5′-untranslated exons. J Neurosci Res 86:3375-3381
24. Long YS, Zhao QH, Zeng T, Zeng Y, Sun WW, Liao WP (2009) Characterization of the promoter region and upstream regulation region of human and mouse SCN3A gene. Prog Biochem Biophys 36:339-345
25. MacDonald JL, Roskams AJ (2009) Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation. Prog Neurobiol 88:170-183
26. Martin MS, Tang B, Ta N, Escayg A (2007) Characterization of 5′ untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cisconserved noncoding sequences. Genomics 90:225-235
27. Nicholson E, Randall AD (2009) Na(v)1.5 sodium channels in a human microglial cell line. J Neuroimmunol 215:25-30
28. Reik W, Dean W, Walter J (2001) Epigenetic reprogramming in mammalian development. Science 293:1089-1093 (Pubitemid 32758081)
29. Robertson KD, Hayward SD, Ling PD, Samid D, Ambinder RF (1995) Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial. Mol Cell Biol 15:6150-6159
30. Ross S, Tienhaara A, Lee MS, Tsai LH, Gill G (2002) GC boxbinding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. J Biol Chem 277:4455-4464 (Pubitemid 34968713)
31. Saleh S, Yeung SY, Prestwich S, Pucovsky V, Greenwood I (2005) Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes. J Physiol 568:155-169 (Pubitemid 41448628)
32. Saxonov S, Berg P, Brutlag DL (2006) A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci USA 103:1412-1417
33. Schade SD, Brown GB (2000) Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A). Brain Res Mol Brain Res 81:187-190
34. Suske G (1999) The Sp-family of transcription factors. Gene 238:291-300
35. Takai D, Jones PA (2002) Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci USA 99:3740-3745 (Pubitemid 34252176)
36. Toselli M, Tosetti P, Taglietti V (1996) Functional changes in sodium conductances in the human neuroblastoma cell line SH-SY5Y during in vitro differentiation. J Neurophysiol 76:3920-3927 (Pubitemid 27009695)
37. Waxman SG (2001) Transcriptional channelopathies: an emerging class of disorders. Nat Rev Neurosci 2:652-659
38. Whitaker WR, Clare JJ, Powell AJ, Chen YH, Faull RL, Emson PC (2000) Distribution of voltage-gated sodium channel alpha-subunit and beta-subunit mRNAs in human hippocampal formation, cortex, and cerebellum. J Comp Neurol 422:123-139 (Pubitemid 30346568)
39. Whitaker WR, Faull RL, Dragunow M, Mee EW, Emson PC, Clare JJ (2001a) Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus. Neuroscience 106:275-285 (Pubitemid 32889629)
40. Whitaker WR, Faull RL, Waldvogel HJ, Plumpton CJ, Emson PC, Clare JJ (2001b) Comparative distribution of voltage-gated sodium channel proteins in human brain. Brain Res Mol Brain Res 88:37-53 (Pubitemid 32274258)
41. Yu FH, Mantegazza M, Westenbroek RE et al (2006) Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci 9:1142-1149 (Pubitemid 44306307)
42. Zhao P, Waxman SG, Hains BC (2006) Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury. Mol Pain 2:27