4-Guanidino-n-butyl syringate (Leonurine, SCM 198) protects H9c2 rat ventricular cells from hypoxia-induced apoptosis

Journal of Cardiovascular Pharmacology

Volumn 54, Issue 5, 2009, Pages 437-444

  Liu, Xin Hua ^a   Chen, Pei Fang ^a   Pan, Li Long ^a   Silva, Ranil De ^c   Zhu, Yi Zhun ^a,b  

^a FUDAN UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c University of Sri Jayewardenepua   (Sri Lanka)

Author keywords

Apoptosis; Cardiomyocytes; Cytosolic Ca2+; Ischemia; Leonurine

Indexed keywords

CALCIUM ION; LACTATE DEHYDROGENASE; LEONURINE; PROTEIN BAX; PROTEIN BCL 2; SCM 198; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL PROTECTION; CONTROLLED STUDY; DRUG ACTIVITY; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CALCIUM; CARDIOTONIC AGENTS; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; CYTOSOL; DRUGS, CHINESE HERBAL; FLOW CYTOMETRY; GALLIC ACID; HEART VENTRICLES; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA, HEART; MOLECULAR STRUCTURE; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SUPEROXIDE DISMUTASE;

EID: 74349131424     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181bae160     Document Type: Article

References (27)

1. Rudin CM, Thompson CB. Apoptosis and disease: regulation and clinical relevance of programmed cell death. Annu Rev Med. 1997;48:267-281.
2. Empel van VP, Hofstral BAT, Crijns HJ, et al. Myocyte apoptosis in heart failure. Cardiovasc Res. 2005;67:21-29.
3. Kajstura J, Cheng W, Sarangarajan R, et al. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am J Physiol. 1996;271:H1215-H1228.
4. Gottlieb RA, Burleson KO, Kloner RA, et al. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest. 1994;94:1621-1628.
5. Bialik S, Cryns VL, Drincic A, et al. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res. 1999;85:403-414.
6. Carrozza JP Jr, Bentivegna LA, Williams CP, et al. Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. Circ Res. 1992;71: 1334-1340.
7. Mochizuki S, MacLeod KT. Effects of hypoxia and metabolic inhibition on increases in intracellular Ca2+ concentration induced by Na+/Ca2+ exchange in isolated guinea-pig cardiac myocytes. J Mol Cell Cardiol. 1997;29:2979-2987.
8. Kong YC, Yeung HW, Cheung YM. Isolation of the uterotonic principle from Leonurus artemisia, the Chinese motherwort. Am J Chin Med. 1976; 4:373-382.
9. Hu S. A contribution to our knowledge of Leonurus L., i-mu-tsáo, the Chinese motherwort. Am J Chin Med. 1976;4:219-237.
10. Wang ZS, Li DW, Xia WJ, et al. The therapeutic effect of Herba leonuri in the treatment of coronary myocardial ischemia. J Tradit Chin Med. 1988; 8:103-106.
11. Sun J, Huang SH, Zhu YC, et al. Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts. Life Sci. 2005;76:3043-3056.
12. Chen CX, Kwan CY. Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort. Life Sci. 2001;68:953-960.
13. Zhu RF, Ni SD, Wang XS. Study on new synthetic process for leonurine. J Anhui univ Nat Sci Ed. 2005;29:84-86.
14. Rakhit RD, Edwards RJ, Mockridge JW. Nitric oxide-induced cardioprotection in cultured rat ventricular myocytes. Am J Physiol Heart Circ Physiol. 2000;278:1211-1217.
15. Kirkin V, Joos S, Zörnig M. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta. 2004;1644:229-249.
16. Anisa J, Wayne RL, Karen LK, et al. Dietary fish oil alters cardiomyocyte Ca2+ dynamics and antioxidant status. Free Radic Biol Med. 2006;40: 1592-1602.
17. Kim MJ, Moon CH, Kim MY, et al. KR-32570, a novel Na+/H+ exchanger-1 inhibitor, attenuates hypoxia-induced cell death through inhibition of intracellular Ca2+ overload and mitochondrial death pathway in H9c2 cells. Eur J Pharmacol. 2005;525:1-7.
18. Goldhaber JI, Weiss JN. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension. 1992;20:118-127.
19. Thandroyen FT, Morris AC, Hagler B, et al. Intracellular calcium transients and arrhythmia in isolated heart cells. Circ Res. 1991;69: 810-819.
20. Asimakis GK, Lick S, Patterson C. Postischemic recovery of contractile function is impaired in SOD2 (6) but not SOD1 (6) mouse hearts. Circulation. 2002;105:981-986.
21. Dhalla NS, Elmoselhi AB, Hata T, et al. Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res. 2000;47:446-456.
22. Bers, DM. Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res. 2002;90:14-17.
23. Tani M. Mechanisms of Ca2+ overload in reperfused ischemicmyocardium. Annu Rev Physiol. 1990;52:543-559.
24. Korge P, Goldhaber JI, Weiss JN. Phenylarsine oxide induces mitochondrial permeability transition, hypercontracture, and cardiac cell death. Am J Physiol Heart Circ Physiol. 2001;280:H2203-H2213.
25. Pan Z, Bhat MB, Nieminen AL, et al. Synergistic movements of Ca2+ and Bax in Cells undergoing apoptosis. J Biol Chem. 2001;276:32257-32263.
26. Kluck RM, Bossy WE, Green DR, et al. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997;275:1132-1136.
27. Uemura K, Adachi AS, Shinatani IK, et al. Carbon monoxide protects cardiomyogenic cells against ischemic death through L-type Ca2+ channel inhibition. Biochem Biophys Res Commun. 2005;334:661-668.