Synthesis of tetrahydronaphthalene lignan esters by intramolecular cyclization of ethyl p-azidophenyl-2-phenylalkanoates and evaluation of the growth inhibition of human tumor cell lines

Journal of Medicinal Chemistry

Volumn 54, Issue 9, 2011, Pages 3175-3187

  Pinto, Orlando ^a   Sardinha, João ^a   Vaz, Pedro D ^a   Piedade, Fátima ^a   Calhorda, Maria J ^a   Abramovitch, Rudolph ^b   Nazareth, Nair ^c   Pinto, Madalena ^c   Nascimento, Maria S J ^c   Rauter, Amélia P ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b CLEMSON UNIVERSITY   (United States)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 IODOETHYL) 3 NITROBENZENE; 1 (2 IODOETHYL) 4 NITROBENZENE; 1 (3 IODOPROPYL) 3 NITROBENZENE; 1 (3 IODOPROPYL) 4 NITROBENZENE; 3 (3 NITROPHENYL)PROPAN 1 OL; 3 (4 NITROPHENYL)PROPAN 1 OL; ANTINEOPLASTIC AGENT; ETHYL 4 (3 AMINOPHENYL) 2 PHENYLBUTANOATE; ETHYL 4 (3 AZIDOPHENYL) 2 PHENYLBUTANOATE; ETHYL 4 (3 NITROPHENYL) 2 PHENYLBUTANOATE; ETHYL 4 (4 AMINOPHENYL) 1,2,3,4 TETRAHYDRONAPHTHALENE 1 CARBOXYLATE; ETHYL 4 (4 AMINOPHENYL) 2 PHENYLBUTANOATE; ETHYL 4 (4 AZIDOPHENYL) 2 PHENYLBUTANOATE; ETHYL 4 (4 NITROPHENYL) 2 PHENYLBUTANOATE; ETHYL 4 [5 AMINO 2 (TRIFLUOROMETHYLSULFONYLOXY)PHENYL] 2 PHENYLBUTANOATE; ETHYL 4 AZIDOPHENYL 2 PHENYLALKANOATE DERIVATIVE; ETHYL 4 OXO 3',4' DIHYDRO 2'H SPIRO(CYCLOHEXA[2,5]DIENE 1,10 NAPHTHALENE) 4' CARBOXYLATE; ETHYL 5 (3 AMINOPHENYL) 2 PHENYLPENTANOATE; ETHYL 5 (3 AZIDOPHENYL) 2 PHENYLPENTANOATE; ETHYL 5 (3 NITROPHENYL) 2 PHENYLPENTANOATE; ETHYL 5 (4 AMINOPHENYL) 2 PHENYLPENTANOATE; ETHYL 5 (4 AZIDOPHENYL) 2 PHENYLPENTANOATE; ETHYL 5 (4 NITROPHENYL) 2 PHENYLPENTANOATE; ETHYL 5 [5 AMINO 2 (TRIFLUOROMETHYLSULFONYLOXY)PHENYL] 2 PHENYLPENTANOATE; HYDROXYACID; METHYL 3 (3 NITROPHENYL)PROP 2 ENOATE; METHYL 3 (4 NITROPHENYL)PROP 2 ENOATE; TETRAHYDRONAPHTHALENE LIGNAN ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CRYSTAL STRUCTURE; CYCLIZATION; DENSITY FUNCTIONAL THEORY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; TUMOR CELL; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; AZIDES; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HUMANS; LIGNANS; MODELS, MOLECULAR; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 79955843003     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101182s     Document Type: Article

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