Synthesis, evaluation, and comparative molecular field analysis of 1- phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H1 receptors

Journal of Medicinal Chemistry

Volumn 42, Issue 16, 1999, Pages 3041-3054

  Bucholtz, Ehren C ^a   Brown, Randal L ^a   Tropsha, Alexander ^a   Booth, Raymond G ^a   Wyrick, Steven D ^a  

^a University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYL 3 AMINO 1,2,3,4 TETRAHYDRONAPHTHALENE DERIVATIVE; HISTAMINE H1 RECEPTOR; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL MODIFICATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; LIGANDS; MODELS, MOLECULAR; PYRILAMINE; RADIOLIGAND ASSAY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 0033549871     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980428x     Document Type: Article

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