Inhibited the activity of PTEN by α-Fetoprotein caused resistance to all trans retinoic acid of hepatoma cells

Progress in Biochemistry and Biophysics

Volumn 38, Issue 3, 2011, Pages 227-238

  Zhu, Ming Yue ^a   Fu, Shi Gan ^a   Li, Meng Sen ^a   Xie, Xie Ju ^a   Li, Gang ^b  

^a HAINAN MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Fetoprotein; Hepatoma cells; Phosphatase and tension homolog deleted on chromosome ten(PTEN); PI3K AKT signal pathway

Indexed keywords

EID: 79955832575     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2010.00546     Document Type: Article

References (46)

1. Semenkova L N, Dudich E I, Dudich I V, et al. Alpha-fetoprotein as a TNF resistance factor for the human hepatocarcinoma cell line HepG2. Tumour Biol, 1997, 18(1):30-40 (Pubitemid 26423282)
2. Li M, Zhou S, Liu X, et al. Alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand. Cancer Lett, 2007, 249(2):227-234 (Pubitemid 46452932)
3. Muto Y, Moriwaki H, Saito A. Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. N Engl J Med, 1999, 340(13):1046-1047 (Pubitemid 29157643)
4. Kizaki M, Ueno H, Matsushita H, et al. Retinoid resistance in leukemic cells. Leuk Lymphoma, 1997, 25 (5-6): 427-434 (Pubitemid 27361887)
5. Sun S Y, Yue P, Chen X, et al. The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells. Cancer Res, 2002, 62(8):2430-2436 (Pubitemid 34411728)
6. Camerini T, Mariani L, Palo G D, et al. Safety of the synthetic retinoid fenretinide: Long-term results from a controlled clinical trial for the prevention of contralateral breast cancer. J Clin Oncol, 2001, 19(6):1664-1670 (Pubitemid 32230866)
7. Wang L, Levin M S. Suppression of FGF signaling: a putative mechanism for the chemopreventive effects of acyclic retinoid in hepatocellular carcinoma. Gastroenterology, 2005, 128(1):228-231 (Pubitemid 40039974)
8. Clerici C, Castellani D, Russo G, et al. Treatment with all-trans retinoic acid plus tamoxifen and vitamin E in advanced hepatocellular carcinoma. Anticancer Res, 2004, 24 (2 C): 1255-1260 (Pubitemid 38624971)
9. Thomas M B, Abbruzzese J L. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol, 2005, 23(31):8093-8108 (Pubitemid 46657412)
10. Chang Y C, Nagasue N, Abe S, et al. Alpha Fetoprotein producing early gastric cancer with liver metastasis: report of three cases. Gut, 1991, 32(5):542-545
11. Takahashi Y, Inoue T. Des-gamma carboxy prothrombin (PIVKA-II) and alpha-fetoprotein producing gastric cancer with multiple liver metastases. Pathol Int, 2003, 53(4):236-240 (Pubitemid 36628232)
12. Ishigami S, Natsugoe S, Nakashima H, et al. Biological aggressiveness of alpha-fetoprotein (AFP)-positive gastric cancer. Hepatogastroenterology, 2006, 53(69):338-341 (Pubitemid 43954402)
13. Iida H, Honda M, Kawai H F, et al. Ephrin-A1 expression contributes to the malignant characteristics of α-fetoprotein producing hepatocellular carcinoma. Gut, 2005, 54(6):843-851 (Pubitemid 40732104)
14. Kamoshida S, Suzuki M, Sakurai Y, et al. Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs. Oncol Rep, 2006, 16(4):721-727
15. Muto Y, Moriwaki H, Ninomiya M, et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. N Engl J Med, 1996, 334(24):1561-1567 (Pubitemid 26177483)
16. Li M S, Li P F, He S P, et al. The promoting molecular mechanism of alpha-fetoprotein on the growth of human hepatoma Bel7402 cell line. World J Gastroenterol, 2002, 8(3):469-475
17. Kim H, Kim E H, Eom Y W, et al. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res, 2006, 66(3):1740-1750 (Pubitemid 43259959)
18. Wang X, Zhou Y, Ying X, et al. Interaction between heat shock protein 72 and alpha-fetoprotein in human hepatocellular carcinomas. Clin Chim Acta, 2007, 379 (1-2): 158-162 (Pubitemid 46366969)
19. Mizejewski G J, MacColl R. α-Fetoprotein growth inhibitory peptides: Potential leads for cancer therapeutics. Mol Cancer Ther, 2003, 2(11):1243-1255
20. Mizejewski G J. Alpha-fetoprotein structure and function: Relevance to isoforms, epitopes, and conformational variants. Exp Biol Med, 2001, 226(5):377-408 (Pubitemid 32506364)
21. Li J, Yen C, Liaw D, et al. PTEN, a putative tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 1997, 275(5308):1943-1947 (Pubitemid 27148818)
22. Stack P A, Pershouse M A, Jasser S A, Y, et al. Identification of a candidate tumour suppressor gene. MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet, 1997, 15(4):356-362 (Pubitemid 27147102)
23. Lu D D, Zhang X R, Cao X R. Expression and significance of new tumor suppressor gene PTEN in primary liver cancer. J Cell Mol Med, 2003, 7(1):67-71
24. Hu T H, Huang C C, Lin P R, et al. Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma. Cancer, 2003, 97(8):1929-1940
25. Sambrook J, Fritsch E F, Maniatis T. Molecular cloning: A laboratory manual. 2nd. New York: Cold Spring Harbor Laboratory Press, 1989:888-897
26. Won Y S, Lee S W. Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA. J Biotechnol, 2007, 129(4):614-619
27. Dudich E, Semenkova L, Dudich I, et al. Alpha-fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase-3-like proteases. Eur J Biochem, 1999, 266(3):750-761 (Pubitemid 30010092)
28. Dudich E, Semenkova L, Dudich I, et al. Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP-caspase interaction. FEBS J, 2006, 273(16):3837-3849 (Pubitemid 44166662)
29. Li M S, Liu X H, Zhou S, et al. Inhibited the expression of alpha fetoprotein by all trans retinoic acid sensitize hepatoma cells to tumor necrosis factor-related apoptosis-induced ligand (TRAIL) [abstract]. Gastroenterology, 2007, 132(4):A822-A823. suppl 2
30. Testa J R, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA, 2001, 98(20):10983-10985 (Pubitemid 32928669)
31. Sodhi A, Montaner S, Patel V, et al. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci USA, 2004, 101(14):4821-4826 (Pubitemid 38469161)
32. Raftopoulou M, Etienne-Manneville S, Self A, et al. Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science, 2004, 303(5661):1179-1181 (Pubitemid 38233580)
33. Georgescu M M, Kirsch K H, Kaloudis P, et al. Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res, 2000, 60(24):7033-7038 (Pubitemid 32059181)
34. Wang L, Wang W L, Zhang Y, et al. Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma. Hepatol Res, 2007, 37(5):389-396 (Pubitemid 46605424)
35. Zhang L, Yu Q, He J, et al. Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines. Mol Cell Biochem, 2004, 262 (1-2): 25-33 (Pubitemid 39158051)
36. Li M, Li H, Li C, et al. Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel7402 cells. Cancer Lett, 2009, 285(2):190-199
37. Shen W H, Balajee A S, Wang J, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 2007, 128(1):157-170 (Pubitemid 46048887)
38. Baker S J. PTEN enters the nuclear age. Cell, 2007, 128(1):25-28 (Pubitemid 46048899)
39. Hede K. PTEN takes center stage in cancer stem cell research, works as tumor suppressor. J Natl Cancer Inst, 2006, 98(12):808-809
40. Ishikawa K, Sasaki A, Haraguchi N, et al. A Case of an α-Fetoprotein-producing intrahepatic cholangiocarcinoma suggests probable cancer stem cell origin. Oncologist, 2007, 12(3):320-324 (Pubitemid 46556798)
41. Khamzina L, Borgeat P. Correlation of α-Fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression. Mol Biol Cell, 1998, 9(5):1093-1105 (Pubitemid 28457302)
42. Liang O D, Korff T, Eckhardt J, et al. Oncodevelopmental α-Fetoprotein acts as a selective proangiogenic factor on endothelial cell from the fetomaternal unit. J Clin Endocrinol Metab, 2004, 89(3):1415-1422 (Pubitemid 38368446)
43. Li M, Li H, Li C, et al. Alpha fetoprotein is a novel protein-binding partner for caspase-3 and blocks the apoptotic signaling pathway in human hepatoma cells. Int J Cancer, 2009, 124(12):2845-2854
44. Yang X, Zhang Y, Zhang L, et al. Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell. Cancer Lett, 2008, 271(7):281-293
45. Li M, Li H, Li C, et al. Alpha-fetoprotein, a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cells lines. Int J Cancer, 2011, 128(3):524-532
46. Mitsuhashi N, Kobayashi S, Doki T, et al. Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma. J Gastroenterol Hepatol, 2008, 23 (7 Pt 2): e189-197 (Pubitemid 352019435)