Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA

Journal of Biotechnology

Volumn 129, Issue 4, 2007, Pages 614-619

  Won, You Sub ^a   Lee, Seong Wook ^a  

^a Dankook University   (South Korea)

Author keywords

Alpha fetoprotein; Cancer gene therapy; Group I intron; Hepatocarcinoma; RNA replacement; Trans splicing ribozyme

Indexed keywords

ALPHA FETOPROTEIN (AFP); CANCER GENE THERAPY; HEPATOCELLULAR CARCINOMA (HCC); RIBOZYME; RNA REPLACEMENT;

CELL GROWTH; ENZYME KINETICS; ONCOGENIC VIRUSES; ONCOLOGY; RNA; TRANSCRIPTION;

TUMORS;

ALPHA FETOPROTEIN; GANCICLOVIR; RIBOZYME; RNA; THYMIDINE KINASE; TRANS SPLICING RIBOZYME; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; REACTION ANALYSIS; RNA SPLICING; SUICIDE GENE;

ALPHA-FETOPROTEINS; ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; DNA, RECOMBINANT; EXONS; GENE THERAPY; HUMANS; INTRONS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; RNA, CATALYTIC; RNA, PROTOZOAN; TETRAHYMENA; TRANSCRIPTION, GENETIC; TRANSFECTION;

SIMPLEXVIRUS;

EID: 34247141907     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2007.02.004     Document Type: Article

References (23)

1. Abelev G.I., and Eraiser T.L. Cellular aspects of alpha-fetoprotein reexpression in tumors. Semin. Cancer Biol. 9 (1999) 95-107
2. Bruix J. Treatment of hepatocellular carcinoma. Hepatology 25 (1997) 259-262
3. Byun J., Lan N., Long M., and Sullenger B.A. Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes. RNA 9 (2003) 1254-1263
4. Hussain S.A., Ferry D.R., El-Gazzaz G., Mirza D.F., James N.D., McMaster P., and Kerr D.J. Hepatocellular carcinoma. Ann. Oncol. 12 (2001) 161-172
5. Jones J.T., Lee S.W., and Sullenger B.A. Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. Nat. Med. 2 (1996) 643-648
6. Jung H.S., and Lee S.W. Ribozyme-mediated selective killing of cancer cells expressing carcinoembryonic antigen RNA by targeted trans-splicing. Biochem. Biophys. Res. Commun. 349 (2006) 556-563
7. Kastanos E., Hjiantoniou E., and Phylactou L.A. Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes. Biochem. Biophys. Res. Commun. 322 (2004) 930-934
8. Kohler U., Ayre B.G., Goodman H.M., and Haseloff J. Trans-splicing ribozymes for targeted gene delivery. J. Mol. Biol. 185 (1999) 1935-1950
9. Kwon B.S., Jung H.S., Song M.S., Cho K.S., Kim S.C., Kimm K., Jeong J.S., Kim I.H., and Lee S.W. Specific regression of human cancer cells by ribozyme-mediated targeted replacement of tumor-specific transcript. Mol. Ther. 12 (2005) 824-834
10. Lan N., Howrey R.P., Lee S.W., Smith C.A., and Sullenger B.A. Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors. Science 280 (1998) 1593-1596
11. Matthews T., and Boehme R. Antiviral activity and mechanism of action of ganciclovir. Rev. Infect. Dis. 10 (1988) S490-S494
12. Mesnil M., Piccoli C., Tiraby G., Willecke K., and Yamasaki H. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 1831-1835
13. Mizejewski G.J. Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants. Exp. Biol. Med. 226 (2001) 377-408
14. Otsuru A., Nagataki S., Koji T., and Tamaoki T. Analysis of alpha-fetoprotein gene expression in hepatocellular carcinoma and liver cirrhosis by in situ hybridization. Cancer 62 (1988) 1105-1112
15. Phylactou L.A., Darrah C., and Wood M.A.J. Ribozyme mediated trans-splicing of a trinucleotide repeat. Nat. Genet. 18 (1998) 378-381
16. Rogers C.S., Vanoye C.G., Sullenger B.A., and George Jr. A.L. Functional repair of a mutant chloride channel using a trans-splicing ribozyme. J. Clin. Invest. 110 (2002) 1783-1798
17. Ryu K.J., Kim J.H., and Lee S.W. Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing. Mol. Ther. 7 (2003) 386-395
18. Shin K.S., Sullenger B.A., and Lee S.W. Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA. Mol. Ther. 10 (2004) 365-372
19. Sullenger B.A., and Cech T.R. Ribozyme-mediated repair of defective mRNA by targeted trans-splicing. Nature 317 (1994) 619-622
20. Taketa K. Alpha-fetoprotein: reevaluation in hepatology. Hepatology 12 (1990) 1420-1432
21. Uch R., Gerolami R., Faivre J., Hardwigsen J., Mathieu S., Mannoni P., and Bagnis B. Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences. Cancer Gene Ther. 10 (2003) 689-695
22. Vollmer C.M., Eilber Jr. F.C., Butterfield L.H., Ribas A., Dissette V.B., Koh A., Montejo L.D., Lee M.C., Andrews K.J., McBride W.H., Glaspy J.A., and Economou J.S. α-Fetoprotein-specific genetic immunotherapy for hepatocellular carcinoma. Cancer Res. 59 (1999) 3064-3067
23. Wang X.W., Yuan J.H., Zhang R.G., Guo L.X., and Xie H. Antihepatoma effect of alpha fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice. World J. Gastroenterol. 7 (2001) 345-351