Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation

Oncogene

Volumn 30, Issue 19, 2011, Pages 2242-2251

  Feng, M ^a   Li, Z ^a   Aau, M ^a   Wong, C H ^a   Yang, X ^a,d   Yu, Q ^a,b,c,d  

^a GENOME INSTITUTE OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

cyclin D1; miR 378; Myc; TOB2

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MICRORNA; MYC PROTEIN; PROTEIN; PROTEIN TOB2; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTO ONCOGENE;

BASE SEQUENCE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICRORNAS; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 79955825405     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.602     Document Type: Article

References (29)

1. Ambros V. (2004). The functions of animal microRNAs. Nature 431: 350-355. (Pubitemid 39265675)
2. Cappellen D, Schlange T, Bauer M, Maurer F, Hynes NE. (2007). Novel c-MYC target genes mediate differential effects on cell proliferation and migration. EMBO Rep 8: 70-76. (Pubitemid 46043803)
3. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM et al. (2008). Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 40: 43-50.
4. Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M et al. (2000). Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Mol Cell Biol 20: 6008-6018. (Pubitemid 30613049)
5. D'Cruz CM, Gunther EJ, Boxer RB, Hartman JL, Sintasath L, Moody SE et al. (2001). c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med 7: 235-239. (Pubitemid 32148492)
6. Dang CV. (1999). c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19: 1-11. (Pubitemid 29018404)
7. Ebert MS, Neilson JR, Sharp PA. (2007). MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Method 4: 721-726. (Pubitemid 47338166)
8. Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, Donaher JL et al. (2001). Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 15: 50-65. (Pubitemid 32060682)
9. Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T et al. (2009). c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458: 762-765.
10. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G et al. (2008). The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601. (Pubitemid 351627379)
11. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S et al. (2005). A microRNA polycistron as a potential human oncogene. Nature 435: 828-833. (Pubitemid 40839734)
12. Jiang X, Tan J, Li J, Kivimae S, Yang X, Zhuang L et al. (2008). DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell 13: 529-541. (Pubitemid 351766796)
13. Kendall SD, Linardic CM, Adam SJ, Counter CM. (2005). A network of genetic events sufficient to convert normal human cells to a tumorigenic state. Cancer Res 65: 9824-9828. (Pubitemid 41541460)
14. Korpal M, Lee ES, Hu G, Kang Y. (2008). The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283: 14910-14914.
15. Kuttler F, Ame P, Clark H, Haughey C, Mougin C, Cahn JY et al. (2001). c-myc box II mutations in Burkitt's lymphoma-derived alleles reduce cell-transformation activity and lower response to broad apoptotic stimuli. Oncogene 20: 6084-6094. (Pubitemid 32955051)
16. Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D et al. (2010). miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12: 247-256.
17. Meyer N, Penn LZ. (2008). Reflecting on 25 years with MYC. Nat Rev Cancer 8: 976-990.
18. Oster SK, Mao DY, Kennedy J, Penn LZ. (2003). Functional analysis of the N-terminal domain of the Myc oncoprotein. Oncogene 22: 1998-2010. (Pubitemid 36523637)
19. Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. (2000). Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14: 2501-2514.
20. Shapiro GI. (2006). Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 24: 1770-1783. (Pubitemid 46628473)
21. Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P. (1987). Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49: 465-475. (Pubitemid 18091823)
22. Stacey D, Kazlauskas A. (2002). Regulation of Ras signaling by the cell cycle. Curr Opin Genet Dev 12: 44-46. (Pubitemid 34094988)
23. Suzuki T, Junko KT, Ajima R, Nakamura T, Yoshida Y, Yamamoto T. (2002). Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes Dev 16: 1356-1370.
24. Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL et al. (2007). Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 21: 1050-1063. (Pubitemid 46686474)
25. Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC et al. (2009). A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137: 1032-1046.
26. Winkler GS. (2010). The mammalian anti-proliferative BTG/Tob protein family. J Cell Physiol 222: 66-72.
27. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M et al. (2009). miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 23: 2388-2393.
28. Yoshida Y, Nakamura T, Komoda M, Satoh H, Suzuki T, Tsuzuku JK et al. (2003). Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev 17: 1201-1206. (Pubitemid 36583162)
29. Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT et al. (2006). Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci USA 103: 17834-17839. (Pubitemid 44852246)