Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 7, 2011, Pages 1790-1796

  Yang, Runying ^a,b   Hou, Yue Xian ^a   Campbell, Chase A ^a,c   Palaniyandi, Kanagaraj ^a   Zhao, Qing ^a,d   Bordner, Andrew J ^a   Chang, Xiu Bao ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MARICOPA MEDICAL CENTER   (United States)

Author keywords

ATP binding hydrolysis; ATP dependent; Glutamine residue in Q loop; Km and Vmax values; LTC4 transport; Metal cofactor; MRP1

Indexed keywords

ADENOSINE TRIPHOSPHATE MAGNESIUM; ASPARAGINE; GLUTAMINE; LEUCINE; LEUKOTRIENE C4; METHIONINE; MULTIDRUG RESISTANCE PROTEIN 1; MUTANT PROTEIN;

AMINO ACID ANALYSIS; AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN NUCLEIC ACID INTERACTION; PROTEIN TRANSPORT; RESIDUE ANALYSIS; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA PRIMERS; DRUG RESISTANCE, MULTIPLE; GLUTAMINE; HUMANS; HYDROLYSIS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; PHOTOAFFINITY LABELS; SPODOPTERA;

BACTERIA (MICROORGANISMS);

EID: 79955807380     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.02.004     Document Type: Article

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