Human chorionic gonadotropin induces neuronal differentiation of PC12 cells through activation of stably expressed lutropin/choriogonadotropin receptor

Endocrinology

Volumn 148, Issue 12, 2007, Pages 5865-5873

  Meng, Xing Li ^a   Rennert, Owen M ^a   Chan, Wai Yee ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; LUTEINIZING HORMONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; HORMONE ACTION; HUMAN; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CHORIONIC GONADOTROPIN; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE KINASE 4; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PLASMIDS; RATS; RECEPTORS, LH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSFECTION; TYPE C PHOSPHOLIPASES;

EID: 36349011418     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0941     Document Type: Article

References (47)

1. Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW 1994 Crystal structure of human chorionic gonadotropin. Nature 369:455-461
2. Bagshawe KD, Orr AH, Rushworth AG 1968 Relationship between concentrations of human chorionic gonadotrophin in plasma and cerebrospinal fluid. Nature 217:950-951
3. Hostetter G, Gallo RV, Brownfield MS 1981 Presence of immunoreactive luteinizing hormone in the rat forebrain. Neuroendocrinology 33:241-245
4. Birken S, Maydelman Y, Gawinowicz MA, Pound A, Liu Y, Hartree AS 1996 Isolation and characterization of human pituitary chorionic gonadotropin. Endocrinology 137:1402-1411
5. McFarland KC, Sprengel R, Phillips HS, Kohler M, Rosemblit N, Nikolics K, Segaloff DL, Seeburg PH 1989 Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science 245:494-499
6. Rao CV 2001 An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine. Semin Reprod Med 19:7-17
7. Lei ZM, Rao CV 2001 Neural actions of luteinizing hormone and human chorionic gonadotropin. Semin Reprod Med 19:103-109
8. AL-Hader AA, Tao YX, Lei ZM, Rao CV 1997 Fetal rat brains contain luteinizing hormone/human chorionic gonadotropin receptors. Early Pregnancy 3:323-329
9. Lei ZM, Rao CV, Kornyei JL, Licht P, Hiatt ES 1993 Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology 132:2262-2270
10. Thompson DA, Othman MI, Lei Z, Li X, Huang ZH, Eadie DM, Rao CV 1998 Localization of receptors for luteinizing hormone/chorionic gonadotropin in neural retina. Life Sci 63:1057-1064
11. Bukovsky A, Indrapichate K, Fujiwara H, Cekanova M, Ayala ME, Dominguez R, Caudle MR, Wimalsena J, Elder RF, Copas P, Foster JS, Fernando RI, Henley DC, Upadhyaya NB 2003 Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease. Reprod Biol Endocrinol 1:46
12. Rao SC, Li X, Rao ChV, Magnuson DS 2003 Human chorionic gonadotropin/luteinizing hormone receptor expression in the adult rat spinal cord. Neurosci Lett 336:135-138
13. AL-Hader AA, Lei ZM, Rao CV 1997 Neurons from fetal rat brains contain functional luteinizing hormone/chorionic gonadotropin receptors. Biol Reprod 56:1071-1076
14. Zhang W, Lei ZM, Rao CV 1999 Immortalized hippocampal cells contain functional luteinizing hormone/human chorionic gonadotropin receptors. Life Sci 65:2083-2098
15. AL-Hader AA, Lei ZM, Rao CV 1997 Novel expression of functional luteinizing hormone/chorionic gonadotropin receptors in cultured glial cells from neonatal rat brains. Biol Reprod 56:501-507
16. Patil AA, Nagaraj MP 1983 The effect of human chorionic gonadotropin (HCG) on functional recovery of spinal cord sectioned rats. Acta Neurochir (Wien) 69:205-218
17. Patil AA, Filmore K, Hill D 1990 The effect of human chorionic gonadotropin (HCG) on restoration of physiological continuity of the spinal cord. A preliminary report. Int Surg 75:54-57
18. Greene LA, Tischler AS 1976 Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428
19. Rydel RE, Greene LA 1987 Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells. J Neurosci 7:3639-3653
20. Heasley LE, Johnson GL 1992 The β-PDGF receptor induces neuronal differentiation of PC12 cells. Mol Biol Cell 3:545-553
21. Deutsch PJ, Sun Y 1992 The 38-amino acid form of pituitary adenylate cyclaseactivating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth. J Biol Chem 267:5108-5113
22. Vaudry D, Stork PJ, Lazarovici P, Eiden LE 2002 Signaling pathways for PC12 cell differentiation: making the right connections. Science 296:1648-1649
23. Liu G, Duranteau L, Carel JC, Monroe J, Doyle DA, Shenker A 1999 Leydigcell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. N Engl J Med 341:1731-1736
24. Hirakawa T, Galet C, Ascoli M 2002 MA-10 cells transfected with the human lutropin/choriogonadotropin receptor (hLHR): a novel experimental paradigm to study the functional properties of the hLHR. Endocrinology 143:1026-1035
25. Shenker A, Laue L, Kosugi S, Merendino JJ Jr., Minegishi T, Cutler Jr GB 1993 A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 365:652-654
26. Bernard MP, Myers RV, Moyle WR 1998 Lutropins appear to contact two independent sites in the extracellular domain of their receptors. Biochem J 335:611-617
27. Grumolato L, Alexandre D, Turquier V, Ait-Ali D, Fournier A, Vaudry H, Anouar Y 2002 Pituitary adenylate cyclase-activating polypeptide regulates neuroendocrine markers and transcription factors in differentiating pheochromocytoma cells. Ann NY Acad Sci 971:467-470
28. Ravni A, Bourgault S, Lebon A, Chan P, Galas L, Fournier A, Vaudry H, Gonzalez B, Eiden LE, Vaudry D 2006 The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways. J Neurochem 98:321-329
29. Fisher DA 1998 Endocrinology of fetal development. In: Wilson JD, ed. Williams textbook of endocrinology. 9th ed. Los Angeles: University of California; 1273-1301
30. Colucci-D'Amato L, Bonavita V, di Porzio U 2006 The end of the central dogma of neurobiology: stem cells and neurogenesis in adult CNS. Neurol Sci 27:266-270
31. Gage FH 2000 Mammalian neural stem cells. Science 287:1433-1438
32. Gage FH 2002 Neurogenesis in the adult brain. J Neurosci 22:612-613
33. Weissenberger AA, Leschek EW, Zametkin AJ 2001 Case study: sexual hyperactivity treated with psychostimulants in familial male precocious puberty. J Am Acad Child Adolesc Psychiatry 40:373-376
34. Dawbarn D, Allen SJ 2003 Neurotrophins and neurodegeneration. Neuropathol Appl Neurobiol 29:211-230
35. Chao MV, Rajagopal R, Lee FS 2006 Neurotrophin signalling in health and disease. Clin Sci (Lond) 110:167-173
36. Marshall CJ 1995 Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185
37. Vaillancourt RR, Heasley LE, Zamarripa J, Storey B, Valius M, Kazlauskas A, Johnson GL 1995 Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol 15:3644-3653
38. Morooka T, Nishida E 1998 Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J Biol Chem 273:24285-24288
39. Iwasaki S, Iguchi M, Watanabe K, Hoshino R, Tsujimoto M, Kohno M 1999 Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2. J Biol Chem 274:26503-26510
40. Xiao J, Liu Y 2003 Differential roles of ERK and JNK in early and late stages of neuritogenesis: a study in a novel PC12 model system. J Neurochem 86:1516-1523
41. Ashcroft M, Stephens RM, Hallberg B, Downward J, Kaplan DR 1999 The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth. Oncogene 18:4586-4597
42. 2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells. J Biol Chem 267:4479-4488
43. Lazarovici P, Jiang H, Fink Jr D 1998 The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21(ras) G protein, and pp60(c-src) cytoplasmic tyrosine kinase. Mol Pharmacol 54:547-558
44. Lei ZM, Yang M, Li X, Takikawa O, Rao CV 2007 Upregulation of placental indoleamine 2,3-dioxygenase by human chorionic gonadotropin. Biol Reprod 76:639-644
45. Bouschet T, Perez V, Fernandez C, Bockaert J, Eychene A, Journot L 2003 Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells. J Biol Chem 278:4778-4785
46. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJ 1998 Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622-626
47. Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJ 1997 cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73-82