Synthesis and anticancer activities of new benzothiadiazinyl hydrazinecarboxamides and anilino[1,2,4]triazolo[1,5-b][1,2,4]thiadiazine 5,5-diones

Medicinal Chemistry

Volumn 7, Issue 3, 2011, Pages 165-172

  Kamal, Ahmed ^a   Srikanth, Y V V ^a   Ashraf, Md ^a   Khan, M Naseer A ^a   Shaik, Thokhir Basha ^a   Kalivendi, Shasi V ^a   Suri, Nitasha ^b   Saxena, A K ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Anticancer activity; Hydrazinecarboxamides; Triazolo benzothiadiazines; Tubulin polymerization

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 2 (2 NAPHTHYLAMINO) 10 PHENYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 (3 CHLOROANILINO) 10 METHYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 (3 CHLOROANILINO) 10 PHENYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 (4 CHLOROANILINO) 10 METHYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 (4 CHLOROANILINO) 10 PHENYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 (4 METHOXYANILINO) 10 METHYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 (4 METHOXYANILINO) 10 PHENYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 [3,5 DI(TRIFLUOROMETHYL)ANILINO] 10 METHYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 [3,5 DI(TRIFLUOROMETHYL)ANILINO] 10 PHENYL 5,10 DIHYDRO 5LAMBDA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; ANILINO[1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOTHIADIAZINE DERIVATIVE; BENZOTHIADIAZINYLHYDRAZINECARBOXAMIDE DERIVATIVE; HYDRAZINE DERIVATIVE; MOLECULAR SCAFFOLD; N1 (2 NAPHTHYL) 2 (1,1 DIOXO 4 PHENYL 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 (3 CHLOROPHENYL) 2 (1,1 DIOXO 4 PHENYL 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 (3 CHLOROPHENYL) 2 (4 METHYL 1,1 DIOXO 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 (4 CHLOROPHENYL) 2 (1,1 DIOXO 4 PHENYL 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 (4 CHLOROPHENYL) 2 (4 METHYL 1,1 DIOXO 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 (4 METHOXYPHENYL) 2 (1,1 DIOXO 4 PHENYL 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 (4 METHOXYPHENYL) 2 (4 METHYL 1,1 DIOXO 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 [3,5 DI(TRIFLUOROMETHYL)PHENYL] 2 (1,1 DIOXO 4 PHENYL 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 [3,5 DI(TRIFLUOROMETHYL)PHENYL] 2 (4 METHYL 1,1 DIOXO 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; N1 [4 (TERT BUTYL) 2 METHOXYPHENYL] 2 (1,1 DIOXO 4 PHENYL 1,4 DIHYDRO 1LAMBDA 6, 2,4 BENZOTHIADIAZIN 3 YL) 1 HYDRAZINECARBOXAMIDE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; MALE; POLYMERIZATION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BENZOTHIADIAZINES; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDRAZINES; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES; TRIAZOLES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 79955774720     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340611795564259     Document Type: Article

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