ORAI1-mediated calcium influx in lactation and in breast cancer

Molecular Cancer Therapeutics

Volumn 10, Issue 3, 2011, Pages 448-460

  McAndrew, Damara ^a   Grice, Desma M ^a   Peters, Amelia A ^a   Davis, Felicity M ^a   Stewart, Teneale ^a   Rice, Michelle ^a   Smart, Chanel E ^a,b   Brown, Melissa A ^a   Kenny, Paraic A ^c   Roberts Thomson, Sarah J ^a   Monteith, Gregory R ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; SMALL INTERFERING RNA; STROMAL INTERACTION MOLECULE 1; STROMAL INTERACTION MOLECULE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CALCIUM TRANSPORT; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INVOLUTION; LACTATION; NONHUMAN; NULLIPARA; PREGNANCY; PRIORITY JOURNAL; PROGNOSIS; REGULATORY MECHANISM;

ANIMALS; BREAST NEOPLASMS; CALCIUM; CALCIUM CHANNELS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LACTATION; MEMBRANE PROTEINS; MICE; NEOPLASM PROTEINS; RNA, SMALL INTERFERING;

EID: 79955757949     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-0923     Document Type: Article

References (54)

1. Clapham DE. Calcium signaling. Cell 1995;80:259-68.
2. Shennan DB, Peaker M. Transport of milk constituents by the mammary gland. Physiol Rev 2000;80:925-51. (Pubitemid 30452007)
3. Allen JC, Keller RP, Archer P, Neville MC. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr 1991;54:69-80. (Pubitemid 21898919)
4. Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ. Calcium and cancer: targeting Ca2+ transport. Nat Rev Cancer 2007;7:519-30. (Pubitemid 46985398)
5. Roderick HL, Cook SJ. Ca2 +signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer 2008;8:361-75. (Pubitemid 351589702)
6. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006;441:179-85.
7. Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, et al. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 2006;312:1220-3. (Pubitemid 43801149)
8. Roberts-Thomson SJ, Peters AA, Grice DM, Monteith GR. ORAI-mediated calcium entry: mechanism and roles, diseases and pharmacology. Pharmacol Ther 2010;127:121-30.
9. Prakriya M, Lewis RS. Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode. J Gen Physiol 2006;128:373-86. (Pubitemid 44306715)
10. Vig M, Beck A, Billingsley JM, Lis A, Parvez S, Peinelt C, et al. CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr Biol 2006;16:2073-9. (Pubitemid 44573821)
11. Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS. Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature 2008;454:538-42.
12. Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE, Jr , et al. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol 2005;15:1235-41. (Pubitemid 40950523)
13. Yang S, Zhang JJ, Huang XY. Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 2009;15:124-34.
14. Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, et al. Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun 2008;369:977-81.
15. Lee WJ, Roberts-Thomson SJ, Monteith GR. Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochem Biophys Res Commun 2005;337:779-83. (Pubitemid 41446982)
16. Hynes NE, Taverna D, Harwerth IM, Ciardiello F, Salomon DS, Yamamoto T, et al. Epidermal growth factor receptor, but not c-erbB-2, activation prevents lactogenic hormone induction of the beta-casein gene in mouse mammary epithelial cells. Mol Cell Biol 1990;10:4027-34.
17. Suchanek KM, May FJ, Robinson JA, Lee WJ, Holman NA, Monteith GR, et al. Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231. Mol Carcinog 2002;34:165-71. (Pubitemid 34839999)
18. Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J, et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 2006;12:1197-205.
19. Birmingham A, Anderson EM, Reynolds A, Ilsley-Tyree D, Leake D, Fedorov Y, et al. 30 UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Methods 2006;3:199-204.
20. Lee WJ, Robinson JA, Holman NA, McCall MN, Roberts-Thomson SJ, Monteith GR. Antisense-mediated Inhibition of the plasma membrane calcium-ATPase suppresses proliferation of MCF-7 cells. J Biol Chem 2005;280:27076-84. (Pubitemid 41040745)
21. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002;347:1999-2009. (Pubitemid 35461656)
22. Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sorlie T, et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci U S A 2005;102:3738-43. (Pubitemid 40354681)
23. Reinhardt TA, Filoteo AG, Penniston JT, Horst RL. Ca(2+)-ATPase protein expression in mammary tissue. Am J Physiol Cell Physiol 2000;279:C1595-602.
24. Reinhardt TA, Horst RL. Ca2+-ATPases and their expression in the mammary gland of pregnant and lactating rats. Am J Physiol 1999;276:C796-802.
25. Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, et al. STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol 2006;8:1003-10.
26. Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol 2007;9:636-45. (Pubitemid 47214725)
27. Lee WJ, Monteith GR, Roberts-Thomson SJ. Calcium transport and signaling in the mammary gland: targets for breast cancer. Biochim Biophys Acta 2006;1765:235-55.
28. Monteith GR, Bird GS. Techniques: high-throughput measurement of intracellular Ca(2+) - back to basics. Trends Pharmacol Sci 2005;26:218-23.
29. Peel SE, Liu B, Hall IP. ORAI and store-operated calcium influx in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2008;38:744-9. (Pubitemid 351841577)
30. Dery O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 1998;274:C1429-52.
31. Ge L, Shenoy SK, Lefkowitz RJ, DeFea K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. J Biol Chem 2004;279:55419-24. (Pubitemid 40066542)
32. Hjortoe GM, Petersen LC, Albrektsen T, Sorensen BB, Norby PL, Mandal SK, et al. Tissue factor-factor VIIa-specific up-regulation of IL- 8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood 2004;103:3029-37. (Pubitemid 38451676)
33. Matej R, Mandakova P, Netikova I, Pouckova P, Olejar T. Proteinase-activated receptor-2 expression in breast cancer and the role of trypsin on growth and metabolism of breast cancer cell line MDA MB-231. Physiol Res 2007;56:475-84.
34. Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res 2006;66:307-14. (Pubitemid 43166037)
35. Brandman O, Liou J, Park WS, Meyer T. STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Cell 2007;131:1327-39. (Pubitemid 350297421)
36. Danielson KG, Oborn CJ, Durban EM, Butel JS, Medina D. Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc Natl Acad Sci U S A 1984;81:3756-60. (Pubitemid 14087797)
37. Desrivieres S, Prinz T, Castro-Palomino Laria N, Meyer M, Boehm G, Bauer U, et al. Comparative proteomic analysis of proliferating and functionally differentiated mammary epithelial cells. Mol Cell Proteomics 2003;2:1039-54.
38. Soboloff J, Spassova MA, Hewavitharana T, He LP, Xu W, Johnstone LS, et al. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry. Curr Biol 2006;16:1465-70. (Pubitemid 44088459)
39. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
40. Neville MC. Calcium secretion into milk. J Mammary Gland Biol Neoplasia 2005;10:119-28. (Pubitemid 41031002)
41. Reinhardt TA, Lippolis JD, Shull GE, Horst RL. Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J Biol Chem 2004;279:42369-73.
42. Lis A, Peinelt C, Beck A, Parvez S, Monteilh-Zoller M, Fleig A, et al. CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties. Curr Biol 2007;17:794-800.
43. Mercer JC, Dehaven WI, Smyth JT, Wedel B, Boyles RR, Bird GS, et al. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem 2006;281:24979-90. (Pubitemid 44274268)
44. Kim MS, Zeng W, Yuan JP, Shin DM, Worley PF, Muallem S. Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem 2009;284:9733-41.
45. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, et al. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem 2007;282:9105-16. (Pubitemid 47093540)
46. Abdullaev IF, Bisaillon JM, Potier M, Gonzalez JC, Motiani RK, Trebak M. Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res 2008;103:1289-99.
47. DeHaven WI, Jones BF, Petranka JG, Smyth JT, Tomita T, Bird GS, et al. TRPC channels function independently of STIM1 and Orai1. J Physiol 2009;587:2275-98.
48. Yoshimoto A, Nakanishi K, Anzai T, Komine S. Effects of inositol 1,4,5-trisphosphate on calcium release from the endoplasmic reticulum and Golgi apparatus in mouse mammary epithelial cells: a comparison during pregnancy and lactation. Cell Biochem Funct 1990;8:191-8.
49. Scrimgeour N, Litjens T, Ma L, Barritt GJ, Rychkov GY. Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins. J Physiol 2009.
50. Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, et al. Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell 2010;143:84-98.
51. Motiani RK, Abdullaev IF, Trebak M. A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. J Biol Chem 2010;285:19173-83.
52. Ruano Y, Mollejo M, Ribalta T, Fiano C, Camacho FI, Gomez E, et al. Identification of novel candidate target genes in amplicons of Glio- blastoma multiforme tumors detected by expression and CGH micro-array profiling. Mol Cancer 2006;5:39.
53. Scrideli CA, Carlotti CG Jr, Okamoto OK, Andrade VS, Cortez MA, Motta FJ, et al. Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR. J Neurooncol 2008;88:281-91.
54. Sabbioni S, Barbanti-Brodano G, Croce CM, Negrini M. GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. Cancer Res 1997;57:4493-7. (Pubitemid 27441051)