Comparison of the expression and function of ATP binding cassette transporters in Caco-2 and T84 cells on stimulation by selected endogenous compounds and xenobiotics

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 2, 2011, Pages 145-153

  Naruhashi, Kazumasa ^a   Kurahashi, Yuko ^a   Fujita, Yukari ^a   Kawakita, Eri ^a   Yamasaki, Yuna ^a   Hattori, Kana ^a   Nishimura, Asako ^a   Shibata, Nobuhito ^a  

^a DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

Author keywords

ABC transporter; Caco 2; Expression; Function; Rhodamine 123; T84

Indexed keywords

BILE ACID; BILIRUBIN; DIGOXIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; RHODAMINE 123; RIFAMPICIN;

ARTICLE; CELL CULTURE EQUIPMENT; CELL STRAIN CACO 2; CELL STRAIN T84; CONTROLLED STUDY; DRUG TRANSPORT; GENE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2 GENE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3 GENE; MULTIDRUG RESISTANCE PROTEIN 1 GENE; NUCLEOTIDE SEQUENCE; PLASTIC DISH; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSWELL POLYCARBONATE FILTER;

EID: 79955709672     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-075     Document Type: Article

References (30)

1. Tsuji, A.: Tissue selective drug delivery utilizing carrier-mediated transport systems. J. Control. Release, 62: 239-244 (1999).
2. Tom, B. H., Rutzky, L. P., Jakstys, M. M., Oyasu, R., Kaye, C. I. and Kahan, B. D.: Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro, 12: 180-191 (1976).
3. Li, Q., Sai, Y., Kato, Y., Tamai, I. and Tsuji, A.: Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines. Pharm. Res., 20: 1119-1124(2003).
4. Hidalgo, I. J., Raub, T. J. and Borchardt, R. T.: Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96: 736-749(1989).
5. Artursson, P. and Karlsson, J.: Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun., 175: 880-885 (1991).
6. Yamashita, S., Furubayashi, T., Kataoka, M., Sakane, T., Sezaki, H. and Tokuda, H.: Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. Eur. J. Pharm. Sci., 10: 195-204 (2000).
7. Madara, J. L., Stafford, J., Dharmsathaphorn, K. and Carlson, S.: Structural analysis of a human intestinal epithelial cell line. Gastroenterology, 92: 1133-1145 (1987).
8. Dharmsathaphorn, K., McRoberts, J. A., Mandel, K. G., Tisdale, L. D. and Masui, H.: A human colonic tumor cell line that maintains vectorial electrolyte transport. Am. J. Physiol., 246: G204-G208 (1984).
9. Fromm, M. F., Kauffmann, H. M., Fritz, P., Burk, O., Kroemer, H. K., Warzok, R. W., Eichelbaum, M., Siegmund, W. and Schrenk, D.: The effect of rifampin treatment on intestinal expression of human MRP transporters. Am. J. Pathol., 157: 1575-1580 (2000).
10. Terao, T., Hisanaga, E., Sai, Y., Tamai, I. and Tsuji, A.: Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J. Pharm. Pharmacol., 48: 1083-1089 (1996).
11. Naruhashi, K., Tamai, I., Sai, Y., Suzuki, N. and Tsuji, A.: Secretory transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue. J. Pharm. Pharmacol., 53: 73-81 (2001).
12. Lampen, A., Ebert, B., Stumkat, L., Jacob, J. and Seidel, A.: Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. Biochim. Biophys. Acta, 1681: 38-46 (2004).
13. Huang, R., Murry, D. J., Kolwankar, D., Hall, S. D. and Foster, D. R.: Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem. Pharmacol., 71: 1695-1704 (2006).
14. Naruhashi, K., Nadai, M., Nakao, M., Suzuki, N., Nabeshima, T. and Hasegawa, T.: Changes in absorptive function of rat intestine injured by methotrexate. Clin. Exp. Pharmacol. Physiol., 27: 980-986 (2000).
15. Tamai, I., Yamashita, J., Kido, Y., Ohnari, A., Sai, Y., Shima, Y., Naruhashi, K., Koizumi, S. and Tsuji, A.: Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier. J. Pharmacol. Exp. Ther., 295: 146-152 (2000).
16. Naruhashi, K., Tamai, I., Inoue, N., Muraoka, H., Sai, Y., Suzuki, N. and Tsuji, A.: Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. J. Pharm. Pharmacol., 53: 699-709 (2001).
17. Haslam, I. S., Jones, K., Coleman, T. and Simmons, N. L.: Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells. Br. J. Pharmacol., 154: 246-255 (2008).
18. Mottino, A. D. and Catania, V. A.: Hepatic drug transporters and nuclear receptors: Regulation by therapeutic agents. World J. Gastroenterol., 14: 7068-7074 (2008).
19. Teng, S., Jekerle, V. and Piquette-Miller, M.: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab. Dispos., 31: 1296-1299 (2003).
20. Taipalensuu, J., Tornblom, H., Lindberg, G., Einarsson, C., Sjoqvist, F., Melhus, H., Garberg, P., Sjostrom, B., Lundgren, B. and Artursson, P.: Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J. Pharmacol. Exp. Ther., 299: 164-170 (2001).
21. Greiner, B., Eichelbaum, M., Fritz, P., Kreichgauer, H. P., von Richter, O., Zundler, J. and Kroemer, H. K.: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J. Clin. Invest., 104: 147-153 (1999).
22. Tian, R., Koyabu, N., Morimoto, S., Shoyama, Y., Ohtani, H. and Sawada, Y.: Functional induction and de-induction of P-glycoprotein by St. Johnös wort and its ingredients in a human colon adenocarcinoma cell line. Drug Metab. Dispos., 33: 547-554 (2005).
23. Geick, A., Eichelbaum, M. and Burk, O.: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem., 276: 14581-14587 (2001).
24. Naruhashi, K., Tamai, I., Inoue, N., Muraoka, H., Sai, Y., Suzuki, N. and Tsuji, A.: Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats. Antimicrob. Agents Chemother., 46: 344-349 (2002).
25. Kato, Y., Miyazaki, T., Kano, T., Sugiura, T., Kubo, Y. and Tsuji, A.: Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J. Pharm. Sci., 98: 2529-2539 (2009).
26. Haslam, I. S., Jones, K., Coleman, T. and Simmons, N. L.: Induction of P-glycoprotein expression and function in humanintestinal epithelial cells (T84). Biochem. Pharmacol., 76: 850-861 (2008).
27. Heath, J. P.: Epithelial cell migration in the intestine. Cell Biol. Int., 20: 139-146 (1996).
28. Marshman, E., Booth, C. and Potten, C. S.: The intestinal epithelial stem cell. Bioessays, 24: 91-98 (2002).
29. Friederich, E., Pringault, E., Arpin, M. and Louvard, D.: From the structure to the function of villin, an actin-binding protein of the brush border. Bioessays, 12: 403-408 (1990).
30. Kawaguchi, H., Akazawa, Y., Watanabe, Y. and Takakura, Y.: Permeability modulation of human intestinal Caco-2 cell monolayers by interferons. Eur. J. Pharm. Biopharm., 59: 45-50 (2005).