Cholesterol-lowering effects of plant steryl and stanyl laurate by oral administration in mice

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 9, 2011, Pages 5093-5099

  He, Wen Sen ^a   Jia, Cheng Sheng ^a   Yang, Ye Bo ^a   Ma, Yuan ^a   Zhang, Xiao Ming ^a   Feng, Biao ^a   Jin, Jian ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

Oral administration; Plant sterols; Serum cholesterol; Stanols; Stanyl laurate; Steryl laurate

Indexed keywords

LAURATE; ORAL ADMINISTRATION; PLANT STEROLS; SERUM CHOLESTEROL; STANOLS; STANYL LAURATE;

ALCOHOLS; BODY FLUIDS; EMULSIFICATION; EMULSIONS; LIPIDS; LIQUIDS; LIVER;

CHOLESTEROL;

CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; SITOSTEROL DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; DISEASE MODEL; HUMAN; HYPERCHOLESTEROLEMIA; MALE; MOUSE; ORAL DRUG ADMINISTRATION; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL, LDL; DISEASE MODELS, ANIMAL; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MICE; PHYTOSTEROLS; SITOSTEROLS;

MUS;

EID: 79955688512     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf104031e     Document Type: Article

References (30)

1. Plat, J.; Mensink, R. P. Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects. Am. J. Cardiol. 2005, 96, 15D-22D. (Pubitemid 40898165)
2. Lichtenstein, A. H. Plant stanol/sterol ester-containing foods and cardiovascular disease risk. Nutr. Clin. Care 2000, 3, 274-278.
3. Chien, Y. L.; Wu, L. Y.; Lee, T. C.; Hwang, L. S. Cholesterollowering effect of phytosterol-containing lactic-fermented milk powder in hamsters. Food Chem. 2010, 119, 1121-1126.
4. Jia, X.; Chen, Y.; Zidichouski, J.; Zhang, J.; Sun, C.; Wang, Y. Coadministration of berberine and plant stanols synergistically reduces plasma cholesterol in rats. Atherosclerosis 2008, 201, 101-107.
5. Calpe-Berdiel, L.; Escolà-Gil, J. C.; Blanco-Vaca, F. New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism. Atherosclerosis 2009, 203, 18-31.
6. Devaraj, S.; Jialal, I. The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease. Nutr. Rev. 2006, 64, 348-354. (Pubitemid 44124979)
7. Rozner, S.; Garti, N. The activity and absorption relationship of cholesterol and phytosterols. Colloid Surf., A 2006, 282-283, 435-456. (Pubitemid 43816829)
8. Rozman, D.; Monostory, K. Perspectives of the non-statin hypolipidemic agents. Pharmacol. Ther. 2010, 127, 19-40.
9. Moreau, R. A.; Whitaker, B. D.; Hicks, K. B. Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses. Prog. Lipid Res. 2002, 41, 457-500.
10. Chen, Z. Y.; Jiao, R.; Ma, K. Y. Cholesterol-lowering nutraceuticals and functional foods. J. Agric. Food Chem. 2008, 56, 8761-8773.
11. Thompson, G. R.; Grundy, S. M. History and development of plant sterol and stanol esters for cholesterol-lowering purposes. Am. J. Cardiol. 2005, 96, 3D-9D. (Pubitemid 40898163)
12. Lichtenstein, A. H.; Deckelbaum, R. J. Stanol/sterol estercontaining foods and blood cholesterol levels. Circ. J. 2001, 103, 1177-1179.
13. Jones, P. J.; Raeini-Sarjaz, M.; Ntanios, F. Y.; Vanstone, C. A.; Feng, J. Y.; Parsons, W. E. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J. Lipid Res. 2000, 41, 697-705. (Pubitemid 30314125)
14. O'Neill, F. H.; Sanders, T. A.; Thompson, G. R. Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies. Am. J. Cardiol. 2005, 96, 29D-36D. (Pubitemid 40898167)
15. Seppo, L.; Jauhiainen, T.; Nevala, R.; Poussa, T.; Korpela, R. Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol. Eur. J. Nutr. 2007, 46, 111-117. (Pubitemid 46295316)
16. Hallikainen, M. A.; Sarkkinen, E. S.; Uusitupa, M. I. Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. J. Nutr. 2000, 130, 767-776. (Pubitemid 30173660)
17. Kim, J. C.; Kang, B. H.; Shin, C. C.; Kim, Y. B.; Lee, H. S.; Kim, C. Y.; Han, J.; Kim, K. S.; Chung, D. W.; Chung, M. K. Subchronic toxicity of plant sterol esters administered by gavage to Sprague-Dawley rats. Food Chem. Toxicol. 2002, 40, 1569-1580.
18. Li, R.; Jia, C. S.; Yue, L.; Zhang, X. M.; Xia, Q. Y.; Zhao, S. L.; Feng, B.; Zhong, F.; Chen, W. J. Lipase-catalyzed synthesis of conjugated linoleyl β-sitosterol and its cholesterol-lowering properties in mice. J. Agric. Food Chem. 2010, 58, 1898-1902.
19. He, W.; Jia, C.; Ma, Y.; Yang, Y.; Zhang, X.; Feng, B.; Yue, L. Lipase-catalyzed synthesis of phytostanyl esters in non-aqueous media. J. Mol. Catal. B: Enzym. 2010, 67, 60-65.
20. Lin, Y.; Meijer, G. W.; Vermeer, M. A.; Trautwein, E. A. Soy protein enhances the cholesterol-lowering effect of plant sterol esters in cholesterol-fed hamsters. J. Nutr. 2004, 134, 143-148. (Pubitemid 38057437)
21. Meijer, G. W.; Bressers, M. A.; Groot, W. A.; Rudrum, M. Effect of structure and form on the ability of plant sterols to inhibit cholesterol absorption in hamsters. Lipids 2003, 38, 713-721. (Pubitemid 37362263)
22. Zhang, Z.; Wang, H.; Jiao, R.; Peng, C.; Wong, Y. M.; Yeung, V. S.; Huang, Y.; Chen, Z. Y. Choosing hamsters but not rats as a model for studying plasma cholesterol-lowering activity of functional foods. Mol. Nutr. Food Res. 2009, 53, 921-930.
23. Nguyen, T. T. The cholesterol-lowering action of plant stanol esters. J. Nutr. 1999, 129, 2109-2112.
24. Reagan-Shaw, S.; Nihal, M.; Ahmad, N. Dose translation from animal to human studies revisited. FASEB J. 2007, 22, 659-661.
25. Sugano, M.; Morioka, H.; Ikeda, I. A comparison of hypocholesterolemic activity of β-sitosterol and β-sitostanol in rats. J. Nutr. 1977, 107, 2011-2019. (Pubitemid 8205901)
26. Wang, Y.; Jia, X.; Ghanam, K.; Beaurepaire, C.; Zidichouski, J.; Miller, L. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. Atherosclerosis 2010, 209, 111-117.
27. Ming, M.; Guanhua, L.; Zhanhai, Y.; Guang, C.; Xuan, Z. Effect of the lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo. Food Chem. 2009, 113, 872-877.
28. Chung, D. W.; Kim, W. D.; Noh, S. K.; Dong, M. S. Effects of hydrophilic and lipophilic β-sitosterol derivatives on cholesterol absorption and plasma cholesterol levels in rats. J. Agric. Food Chem. 2008, 56, 6665-6670.
29. Hayes, K. C.; Pronczuk, A.; Wijendran, V.; Beer, M. Free phytosterols facilitate excretion of endogenous cholesterol in gerbils. J. Nutr. Biochem. 2005, 16, 305-311. (Pubitemid 41556920)
30. Patricia, F. R.; Jose, A. R.; Luis, M. S.; Sergio, R.; Alfredo, G. L. Egg yolk improves lipid profile, lipid peroxidation and retinal abnormalities in a murine model of genetic hypercholesterolemia. J. Nutr. Biochem. 2008, 19, 40-48.