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Volumn 17, Issue 5, 2011, Pages 244-251

Copy number variants in pharmacogenetic genes

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2D6; ESTROGEN RECEPTOR; GLUTATHIONE TRANSFERASE; NORTAMOXIFEN; NORTRIPTYLINE; TAMOXIFEN;

EID: 79955671884     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2011.01.007     Document Type: Review
Times cited : (91)

References (95)
  • 1
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer U.A. Pharmacogenetics and adverse drug reactions. Lancet 2000, 356:1667-1671.
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 2
    • 32944454759 scopus 로고    scopus 로고
    • Pharmacogenomics and individualized drug therapy
    • Eichelbaum M., et al. Pharmacogenomics and individualized drug therapy. Annu. Rev. Med. 2006, 57:119-137.
    • (2006) Annu. Rev. Med. , vol.57 , pp. 119-137
    • Eichelbaum, M.1
  • 3
    • 29544447266 scopus 로고    scopus 로고
    • The AmpliChip CYP450 genotyping test: integrating a new clinical tool
    • de Leon J., et al. The AmpliChip CYP450 genotyping test: integrating a new clinical tool. Mol. Diagn. Ther. 2006, 10:135-151.
    • (2006) Mol. Diagn. Ther. , vol.10 , pp. 135-151
    • de Leon, J.1
  • 4
    • 1542333321 scopus 로고    scopus 로고
    • Guidance for Industry: Pharmacogenomic Data Submissions
    • USFDA, USFDA
    • USFDA (2005) Guidance for Industry: Pharmacogenomic Data Submissions, USFDA.
    • (2005)
  • 5
    • 34250695169 scopus 로고    scopus 로고
    • Table of Valid Genomic Biomarkers in the Context of Approved Drug Labels
    • USFDA, U.S. FDA
    • USFDA (2008) Table of Valid Genomic Biomarkers in the Context of Approved Drug Labels, U.S. FDA.
    • (2008)
  • 6
    • 70450195266 scopus 로고    scopus 로고
    • Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
    • Normanno N., et al. Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nat. Rev. Clin. Oncol. 2009, 6:519-527.
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 519-527
    • Normanno, N.1
  • 7
    • 38149108354 scopus 로고    scopus 로고
    • A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs
    • Lonjou C., et al. A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics 2008, 18:99-107.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 99-107
    • Lonjou, C.1
  • 8
    • 40449120615 scopus 로고    scopus 로고
    • Genetic determinants of response to warfarin during initial anticoagulation
    • Schwarz U.I., et al. Genetic determinants of response to warfarin during initial anticoagulation. N. Engl. J. Med. 2008, 358:999-1008.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 999-1008
    • Schwarz, U.I.1
  • 9
    • 42449142373 scopus 로고    scopus 로고
    • Pharmacogenomics of anti-TB drugs-related hepatotoxicity
    • Roy P.D., et al. Pharmacogenomics of anti-TB drugs-related hepatotoxicity. Pharmacogenomics 2008, 9:311-321.
    • (2008) Pharmacogenomics , vol.9 , pp. 311-321
    • Roy, P.D.1
  • 10
    • 48249123433 scopus 로고    scopus 로고
    • Pharmacogenomic biomarker information in drug labels approved by the United States food and drug administration: prevalence of related drug use
    • Frueh F.W., et al. Pharmacogenomic biomarker information in drug labels approved by the United States food and drug administration: prevalence of related drug use. Pharmacotherapy 2008, 28:992-998.
    • (2008) Pharmacotherapy , vol.28 , pp. 992-998
    • Frueh, F.W.1
  • 11
    • 34250695169 scopus 로고    scopus 로고
    • Table of Valid Genomic Biomarkers in the Context of Approved Drug Labels
    • USFDA, U.S. FDA
    • USFDA (2006) Table of Valid Genomic Biomarkers in the Context of Approved Drug Labels, U.S. FDA.
    • (2006)
  • 12
    • 51449102329 scopus 로고    scopus 로고
    • Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication
    • Stamer U.M., et al. Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication. Anesth. Analg. 2008, 107:926-929.
    • (2008) Anesth. Analg. , vol.107 , pp. 926-929
    • Stamer, U.M.1
  • 13
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R. Inheritance and drug response. N. Engl. J. Med. 2003, 348:529-537.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 14
    • 33751329250 scopus 로고    scopus 로고
    • Global variation in copy number in the human genome
    • Redon R., et al. Global variation in copy number in the human genome. Nature 2006, 444:444-454.
    • (2006) Nature , vol.444 , pp. 444-454
    • Redon, R.1
  • 15
    • 24944478689 scopus 로고    scopus 로고
    • Detection of chromosomal imbalances in children with idiopathic mental retardation by array based comparative genomic hybridisation (array-CGH)
    • Schoumans J., et al. Detection of chromosomal imbalances in children with idiopathic mental retardation by array based comparative genomic hybridisation (array-CGH). J. Med. Genet. 2005, 42:699-705.
    • (2005) J. Med. Genet. , vol.42 , pp. 699-705
    • Schoumans, J.1
  • 16
    • 29444457877 scopus 로고    scopus 로고
    • Common deletion polymorphisms in the human genome
    • McCarroll S.A., et al. Common deletion polymorphisms in the human genome. Nat. Genet. 2006, 38:86-92.
    • (2006) Nat. Genet. , vol.38 , pp. 86-92
    • McCarroll, S.A.1
  • 17
    • 77950405093 scopus 로고    scopus 로고
    • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
    • Craddock N., et al. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010, 464:713-720.
    • (2010) Nature , vol.464 , pp. 713-720
    • Craddock, N.1
  • 18
    • 62549166700 scopus 로고    scopus 로고
    • CNVs of human genes and their implication in pharmacogenetics
    • Johansson I., Ingelman-Sundberg M. CNVs of human genes and their implication in pharmacogenetics. Cytogenet. Genome Res. 2008, 123:195-204.
    • (2008) Cytogenet. Genome Res. , vol.123 , pp. 195-204
    • Johansson, I.1    Ingelman-Sundberg, M.2
  • 19
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: part I
    • Zhou S.F. Polymorphism of human cytochrome P450 2D6 and its clinical significance: part I. Clin. Pharmacokinet. 2009, 48:689-723.
    • (2009) Clin. Pharmacokinet. , vol.48 , pp. 689-723
    • Zhou, S.F.1
  • 20
    • 67749114265 scopus 로고    scopus 로고
    • CYP2D6 and tamoxifen: DNA matters in breast cancer
    • Hoskins J.M., et al. CYP2D6 and tamoxifen: DNA matters in breast cancer. Nat. Rev. Cancer 2009, 9:576-586.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 576-586
    • Hoskins, J.M.1
  • 21
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity
    • Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 2005, 5:6-13.
    • (2005) Pharmacogenomics J. , vol.5 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 22
    • 2442712928 scopus 로고    scopus 로고
    • *10 does not increase CYP2D6 metabolic activity
    • *10 does not increase CYP2D6 metabolic activity. Clin. Chim. Acta 2004, 344:201-204.
    • (2004) Clin. Chim. Acta , vol.344 , pp. 201-204
    • Ishiguro, A.1
  • 23
    • 33645109079 scopus 로고    scopus 로고
    • *36 with poor metabolizer status
    • *36 with poor metabolizer status. Drug Metab. Dispos. 2006, 34:563-569.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 563-569
    • Gaedigk, A.1
  • 24
    • 0029102348 scopus 로고
    • Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology
    • Steen V.M., et al. Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology. Pharmacogenetics 1995, 5:215-223.
    • (1995) Pharmacogenetics , vol.5 , pp. 215-223
    • Steen, V.M.1
  • 25
    • 33847031732 scopus 로고    scopus 로고
    • CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
    • Sistonen J., et al. CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet. Genomics 2007, 17:93-101.
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 93-101
    • Sistonen, J.1
  • 26
    • 77954952160 scopus 로고    scopus 로고
    • Evolution of detoxifying systems: the role of environment and population history in shaping genetic diversity at human CYP2D6 locus
    • Fuselli S., et al. Evolution of detoxifying systems: the role of environment and population history in shaping genetic diversity at human CYP2D6 locus. Pharmacogenet. Genomics 2010, 20:485-499.
    • (2010) Pharmacogenet. Genomics , vol.20 , pp. 485-499
    • Fuselli, S.1
  • 27
    • 0033408498 scopus 로고    scopus 로고
    • Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population
    • Griese E.U., et al. Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population. Pharmacogenetics 1999, 9:715-723.
    • (1999) Pharmacogenetics , vol.9 , pp. 715-723
    • Griese, E.U.1
  • 28
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford L.D. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 2002, 3:229-243.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 29
    • 79955665445 scopus 로고    scopus 로고
    • NCBI Nortriptyline
    • NCBI (2008) Nortriptyline.
    • (2008)
  • 30
    • 0031668683 scopus 로고    scopus 로고
    • Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes
    • Yue Q.Y., et al. Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes. Clin. Pharmacol. Ther. 1998, 64:384-390.
    • (1998) Clin. Pharmacol. Ther. , vol.64 , pp. 384-390
    • Yue, Q.Y.1
  • 31
    • 0031949132 scopus 로고    scopus 로고
    • 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes
    • Dalen P., et al. 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin. Pharmacol. Ther. 1998, 63:444-452.
    • (1998) Clin. Pharmacol. Ther. , vol.63 , pp. 444-452
    • Dalen, P.1
  • 32
    • 77951779878 scopus 로고    scopus 로고
    • Genome-wide pharmacogenetics of antidepressant response in the GENDEP project
    • Uher R., et al. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am. J. Psychiatry. 2010, 167:555-564.
    • (2010) Am. J. Psychiatry. , vol.167 , pp. 555-564
    • Uher, R.1
  • 33
    • 76049101223 scopus 로고    scopus 로고
    • Endometrial profile of tamoxifen and low-dose estradiol combination therapy
    • Wood C.E., et al. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin. Cancer Res. 2010, 16:946-956.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 946-956
    • Wood, C.E.1
  • 34
    • 30444434216 scopus 로고    scopus 로고
    • Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer
    • Jordan V.C. Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. Br. J. Pharmacol. 2006, 147(Suppl. 1):S269-S276.
    • (2006) Br. J. Pharmacol. , vol.147 , Issue.SUPPL. 1
    • Jordan, V.C.1
  • 35
    • 38749113914 scopus 로고    scopus 로고
    • Pharmacogenomics of tamoxifen and aromatase inhibitors
    • Ingle J.N. Pharmacogenomics of tamoxifen and aromatase inhibitors. Cancer 2008, 112:695-699.
    • (2008) Cancer , vol.112 , pp. 695-699
    • Ingle, J.N.1
  • 36
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6
    • Desta Z., et al. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J. Pharmacol. Exp. Ther. 2004, 310:1062-1075.
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 1062-1075
    • Desta, Z.1
  • 37
    • 3342932419 scopus 로고    scopus 로고
    • Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
    • Johnson M.D., et al. Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res. Treat. 2004, 85:151-159.
    • (2004) Breast Cancer Res. Treat. , vol.85 , pp. 151-159
    • Johnson, M.D.1
  • 38
    • 33745347897 scopus 로고    scopus 로고
    • Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment
    • Borges S., et al. Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment. Clin. Pharmacol. Ther. 2006, 80:61-74.
    • (2006) Clin. Pharmacol. Ther. , vol.80 , pp. 61-74
    • Borges, S.1
  • 39
    • 77957559661 scopus 로고    scopus 로고
    • Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial
    • (in press), doi:10.1038/tpj.2010.17
    • Serrano, D. et al.Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. Pharmacogenomics J.(in press), doi:10.1038/tpj.2010.17.
    • Pharmacogenomics J.
    • Serrano, D.1
  • 40
    • 77956242845 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification
    • Schroth W., et al. CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification. Clin. Cancer Res. 2010, 16:4468-4477.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4468-4477
    • Schroth, W.1
  • 41
    • 0033778598 scopus 로고    scopus 로고
    • Metoprolol: a review of its use in chronic heart failure
    • Prakash A., Markham A. Metoprolol: a review of its use in chronic heart failure. Drugs 2000, 60:647-678.
    • (2000) Drugs , vol.60 , pp. 647-678
    • Prakash, A.1    Markham, A.2
  • 42
    • 25844473190 scopus 로고    scopus 로고
    • Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study
    • Fux R., et al. Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study. Clin. Pharmacol. Ther. 2005, 78:378-387.
    • (2005) Clin. Pharmacol. Ther. , vol.78 , pp. 378-387
    • Fux, R.1
  • 43
    • 4744362912 scopus 로고    scopus 로고
    • Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics
    • Kirchheiner J., et al. Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics. Clin. Pharmacol. Ther. 2004, 76:302-312.
    • (2004) Clin. Pharmacol. Ther. , vol.76 , pp. 302-312
    • Kirchheiner, J.1
  • 44
    • 57049179618 scopus 로고    scopus 로고
    • CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction
    • Goryachkina K., et al. CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction. Eur. J. Clin. Pharmacol. 2008, 64:1163-1173.
    • (2008) Eur. J. Clin. Pharmacol. , vol.64 , pp. 1163-1173
    • Goryachkina, K.1
  • 45
    • 34547644659 scopus 로고    scopus 로고
    • Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
    • Kirchheiner J., et al. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J. 2007, 7:257-265.
    • (2007) Pharmacogenomics J. , vol.7 , pp. 257-265
    • Kirchheiner, J.1
  • 46
    • 69049096090 scopus 로고    scopus 로고
    • Codeine, ultrarapid-metabolism genotype, and postoperative death
    • Ciszkowski C., et al. Codeine, ultrarapid-metabolism genotype, and postoperative death. N. Engl. J. Med. 2009, 361:827-828.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 827-828
    • Ciszkowski, C.1
  • 47
    • 33846465345 scopus 로고    scopus 로고
    • Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine
    • Madadi P., et al. Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine. Can. Fam. Physician 2007, 53:33-35.
    • (2007) Can. Fam. Physician , vol.53 , pp. 33-35
    • Madadi, P.1
  • 48
    • 57749180179 scopus 로고    scopus 로고
    • Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study
    • Madadi P., et al. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin. Pharmacol. Ther. 2009, 85:31-35.
    • (2009) Clin. Pharmacol. Ther. , vol.85 , pp. 31-35
    • Madadi, P.1
  • 50
    • 0035660166 scopus 로고    scopus 로고
    • Metabolic gene polymorphism frequencies in control populations
    • Garte S., et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev. 2001, 10:1239-1248.
    • (2001) Cancer Epidemiol Biomarkers Prev. , vol.10 , pp. 1239-1248
    • Garte, S.1
  • 51
    • 79951576211 scopus 로고    scopus 로고
    • GSTT1 and GSTM1 gene polymorphisms in European and African populations
    • (in press), doi:10.1007/s11033-010-0221-0
    • Piacentini, S. et al.GSTT1 and GSTM1 gene polymorphisms in European and African populations. Mol. Biol. Rep.(in press), doi:10.1007/s11033-010-0221-0.
    • Mol. Biol. Rep.
    • Piacentini, S.1
  • 52
    • 61849125841 scopus 로고    scopus 로고
    • A multiplex real-time PCR method for detection of GSTM1 and GSTT1 copy numbers
    • Timofeeva M., et al. A multiplex real-time PCR method for detection of GSTM1 and GSTT1 copy numbers. Clin. Biochem. 2009, 42:500-509.
    • (2009) Clin. Biochem. , vol.42 , pp. 500-509
    • Timofeeva, M.1
  • 53
    • 77952581540 scopus 로고    scopus 로고
    • GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis
    • Economopoulos K.P., Sergentanis T.N. GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis. Eur. J. Cancer 2010, 46:1617-1631.
    • (2010) Eur. J. Cancer , vol.46 , pp. 1617-1631
    • Economopoulos, K.P.1    Sergentanis, T.N.2
  • 54
    • 77649287869 scopus 로고    scopus 로고
    • Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia
    • Das P., et al. Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia. Leuk Lymphoma 2009, 50:1345-1351.
    • (2009) Leuk Lymphoma , vol.50 , pp. 1345-1351
    • Das, P.1
  • 55
    • 77950349305 scopus 로고    scopus 로고
    • Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma
    • Cho H.J., et al. Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma. Cancer Genet. Cytogenet 2010, 198:40-46.
    • (2010) Cancer Genet. Cytogenet , vol.198 , pp. 40-46
    • Cho, H.J.1
  • 56
    • 0026792979 scopus 로고
    • A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group
    • Farlow M., et al. A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group. J. Am. Med. Assoc. 1992, 268:2523-2529.
    • (1992) J. Am. Med. Assoc. , vol.268 , pp. 2523-2529
    • Farlow, M.1
  • 57
    • 0042888669 scopus 로고    scopus 로고
    • Clinical practice Early Alzheimer's disease
    • Kawas C.H. Clinical practice Early Alzheimer's disease. N. Engl. J. Med. 2003, 349:1056-1063.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1056-1063
    • Kawas, C.H.1
  • 58
    • 45249111114 scopus 로고    scopus 로고
    • Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease
    • Patocka J., et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr. Drug. Metab. 2008, 9:332-335.
    • (2008) Curr. Drug. Metab. , vol.9 , pp. 332-335
    • Patocka, J.1
  • 59
    • 0034112853 scopus 로고    scopus 로고
    • Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity
    • Simon T., et al. Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin. Pharmacol. Ther. 2000, 67:432-437.
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 432-437
    • Simon, T.1
  • 60
    • 58149087995 scopus 로고    scopus 로고
    • NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity
    • Fang L., et al. NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity. J. Med. Chem. 2008, 51:7666-7669.
    • (2008) J. Med. Chem. , vol.51 , pp. 7666-7669
    • Fang, L.1
  • 61
    • 77951591272 scopus 로고    scopus 로고
    • Applying the genome to national drug formulary policy in the developing world
    • Roederer M.W., McLeod H.L. Applying the genome to national drug formulary policy in the developing world. Pharmacogenomics 2010, 11:633-636.
    • (2010) Pharmacogenomics , vol.11 , pp. 633-636
    • Roederer, M.W.1    McLeod, H.L.2
  • 63
    • 17644419314 scopus 로고    scopus 로고
    • CYP2C8 polymorphism frequencies among malaria patients in Zanzibar
    • Cavaco I., et al. CYP2C8 polymorphism frequencies among malaria patients in Zanzibar. Eur. J. Clin. Pharmacol. 2005, 61:15-18.
    • (2005) Eur. J. Clin. Pharmacol. , vol.61 , pp. 15-18
    • Cavaco, I.1
  • 64
    • 0029846193 scopus 로고    scopus 로고
    • Rapid detection of CYP2D6 null alleles by long distance- and multiplex-polymerase chain reaction
    • Stuven T., et al. Rapid detection of CYP2D6 null alleles by long distance- and multiplex-polymerase chain reaction. Pharmacogenetics 1996, 6:417-421.
    • (1996) Pharmacogenetics , vol.6 , pp. 417-421
    • Stuven, T.1
  • 65
    • 0346363770 scopus 로고    scopus 로고
    • CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR
    • Schaeffeler E., et al. CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR. Hum. Mutat. 2003, 22:476-485.
    • (2003) Hum. Mutat. , vol.22 , pp. 476-485
    • Schaeffeler, E.1
  • 66
    • 51249083916 scopus 로고    scopus 로고
    • The array CGH and its clinical applications
    • Shinawi M., Cheung S.W. The array CGH and its clinical applications. Drug. Discov. Today 2008, 13:760-770.
    • (2008) Drug. Discov. Today , vol.13 , pp. 760-770
    • Shinawi, M.1    Cheung, S.W.2
  • 67
    • 17344371740 scopus 로고    scopus 로고
    • High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
    • Pinkel D., et al. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat. Genet. 1998, 20:207-211.
    • (1998) Nat. Genet. , vol.20 , pp. 207-211
    • Pinkel, D.1
  • 68
    • 33749867228 scopus 로고    scopus 로고
    • AmpliChip CYP450 GeneChip: a new gene chip that allows rapid and accurate CYP2D6 genotyping
    • Heller T., et al. AmpliChip CYP450 GeneChip: a new gene chip that allows rapid and accurate CYP2D6 genotyping. Ther. Drug. Monit. 2006, 28:673-677.
    • (2006) Ther. Drug. Monit. , vol.28 , pp. 673-677
    • Heller, T.1
  • 69
    • 59149096567 scopus 로고    scopus 로고
    • The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction
    • Rebsamen M.C., et al. The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction. Pharmacogenomics J. 2009, 9:34-41.
    • (2009) Pharmacogenomics J. , vol.9 , pp. 34-41
    • Rebsamen, M.C.1
  • 70
    • 79959503826 scopus 로고    scopus 로고
    • International HapMap Consortium, The International HapMap Project
    • International HapMap Consortium, The International HapMap Project (2003) Nature 426, 789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 71
    • 67650264006 scopus 로고    scopus 로고
    • The Affymetrix DMET platform and pharmacogenetics in drug development
    • Deeken J. The Affymetrix DMET platform and pharmacogenetics in drug development. Curr. Opin. Mol. Ther. 2009, 11:260-268.
    • (2009) Curr. Opin. Mol. Ther. , vol.11 , pp. 260-268
    • Deeken, J.1
  • 72
    • 0036339071 scopus 로고    scopus 로고
    • Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    • Gaedigk A., et al. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin. Pharmacol. Ther. 2002, 72:76-89.
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 76-89
    • Gaedigk, A.1
  • 73
    • 71049161271 scopus 로고    scopus 로고
    • Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study
    • Lavender N.A., et al. Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study. BMC Cancer 2009, 9:397.
    • (2009) BMC Cancer , vol.9 , pp. 397
    • Lavender, N.A.1
  • 74
    • 77953947158 scopus 로고    scopus 로고
    • Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among Mexican Tepehuanos and Mestizos
    • Sosa-Macias M., et al. Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among Mexican Tepehuanos and Mestizos. Pharmacology 2010, 86:30-36.
    • (2010) Pharmacology , vol.86 , pp. 30-36
    • Sosa-Macias, M.1
  • 75
    • 27944474000 scopus 로고    scopus 로고
    • CYP2D6 genotype and phenotype determination in a Mexican Mestizo population
    • Lopez M., et al. CYP2D6 genotype and phenotype determination in a Mexican Mestizo population. Eur. J. Clin. Pharmacol. 2005, 61:749-754.
    • (2005) Eur. J. Clin. Pharmacol. , vol.61 , pp. 749-754
    • Lopez, M.1
  • 76
    • 67849085493 scopus 로고    scopus 로고
    • *0 in a Mexican Mestizo population: a similitude analysis
    • *0 in a Mexican Mestizo population: a similitude analysis. Hum. Biol. 2008, 80:457-465.
    • (2008) Hum. Biol. , vol.80 , pp. 457-465
    • Perez-Morales, R.1
  • 77
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E., et al. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J. Pharmacol. Exp. Ther. 1996, 278:441-446.
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 441-446
    • Aklillu, E.1
  • 78
    • 33845895505 scopus 로고    scopus 로고
    • Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians
    • Dash B., et al. Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. J. Toxicol. Environ. Health A 2007, 70:58-66.
    • (2007) J. Toxicol. Environ. Health A , vol.70 , pp. 58-66
    • Dash, B.1
  • 79
    • 0036960924 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2D6 in Chinese mainland
    • Ji L., et al. Genetic polymorphisms of CYP2D6 in Chinese mainland. Chin. Med. J. (Engl.) 2002, 115:1780-1784.
    • (2002) Chin. Med. J. (Engl.) , vol.115 , pp. 1780-1784
    • Ji, L.1
  • 80
    • 70350060167 scopus 로고    scopus 로고
    • Genetic polymorphisms of glutathione S-transferase and risk of vitiligo in the Chinese population
    • Liu L., et al. Genetic polymorphisms of glutathione S-transferase and risk of vitiligo in the Chinese population. J. Invest. Dermatol. 2009, 129:2646-2652.
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 2646-2652
    • Liu, L.1
  • 82
    • 0034094251 scopus 로고    scopus 로고
    • Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes
    • Kubota T., et al. Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes. Br. J. Clin. Pharmacol. 2000, 50:31-34.
    • (2000) Br. J. Clin. Pharmacol. , vol.50 , pp. 31-34
    • Kubota, T.1
  • 83
    • 67349248086 scopus 로고    scopus 로고
    • Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians
    • Fujihara J., et al. Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians. Leg. Med. (Tokyo) 2009, 11(Suppl. 1):S408-S410.
    • (2009) Leg. Med. (Tokyo) , vol.11 , Issue.SUPPL. 1
    • Fujihara, J.1
  • 84
    • 33748210748 scopus 로고    scopus 로고
    • Sequence-based CYP2D6 genotyping in the Korean population
    • Lee S.Y., et al. Sequence-based CYP2D6 genotyping in the Korean population. Ther. Drug Monit. 2006, 28:382-387.
    • (2006) Ther. Drug Monit. , vol.28 , pp. 382-387
    • Lee, S.Y.1
  • 85
    • 34250804391 scopus 로고    scopus 로고
    • Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population
    • Uhm Y.K., et al. Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population. Life Sci. 2007, 81:223-227.
    • (2007) Life Sci. , vol.81 , pp. 223-227
    • Uhm, Y.K.1
  • 86
    • 9244240247 scopus 로고    scopus 로고
    • GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma
    • Abbas A., et al. GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma. World J. Gastroenterol. 2004, 10:3389-3393.
    • (2004) World J. Gastroenterol. , vol.10 , pp. 3389-3393
    • Abbas, A.1
  • 87
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences
    • Sachse C., et al. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 1997, 60:284-295.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 284-295
    • Sachse, C.1
  • 88
    • 0030811291 scopus 로고    scopus 로고
    • Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians
    • McLellan R.A., et al. Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians. Pharmacogenetics 1997, 7:187-191.
    • (1997) Pharmacogenetics , vol.7 , pp. 187-191
    • McLellan, R.A.1
  • 89
    • 68049113267 scopus 로고    scopus 로고
    • GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs
    • Abu-Amero K.K., et al. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Br. J. Ophthalmol. 2009, 93:1101-1104.
    • (2009) Br. J. Ophthalmol. , vol.93 , pp. 1101-1104
    • Abu-Amero, K.K.1
  • 90
    • 0033807421 scopus 로고    scopus 로고
    • Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking
    • Rao Y., et al. Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking. Mol. Pharmacol. 2000, 58:747-755.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 747-755
    • Rao, Y.1
  • 91
    • 77951498164 scopus 로고    scopus 로고
    • Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy
    • Lerman C., et al. Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy. Clin. Pharmacol. Ther. 2010, 87:553-557.
    • (2010) Clin. Pharmacol. Ther. , vol.87 , pp. 553-557
    • Lerman, C.1
  • 92
    • 33847042703 scopus 로고    scopus 로고
    • CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?
    • Farinola N., Piller N.B. CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?. Pharmacogenomics 2007, 8:151-158.
    • (2007) Pharmacogenomics , vol.8 , pp. 151-158
    • Farinola, N.1    Piller, N.B.2
  • 93
    • 33645804599 scopus 로고    scopus 로고
    • Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review
    • Yang P., et al. Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review. J. Clin. Oncol. 2006, 24:1761-1769.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1761-1769
    • Yang, P.1
  • 94
    • 0036157818 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferase type 2 and glutathione S-transferases M1 and T1 polymorphisms in familial adenomatous polyposis
    • Lamberti C., et al. Arylamine N-acetyltransferase type 2 and glutathione S-transferases M1 and T1 polymorphisms in familial adenomatous polyposis. Pharmacogenetics 2002, 12:49-54.
    • (2002) Pharmacogenetics , vol.12 , pp. 49-54
    • Lamberti, C.1
  • 95
    • 57149123783 scopus 로고    scopus 로고
    • Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis
    • Yang T.L., et al. Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. Am. J. Hum. Genet. 2008, 83:663-674.
    • (2008) Am. J. Hum. Genet. , vol.83 , pp. 663-674
    • Yang, T.L.1


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