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The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyl-transferases in man using sparteine, caffeine, and paracetamol as probes
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Bock KW, Schrenk D, Forster A, Griese EU, Mörike K, Brockmeier D, Eichelbaum M. The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyl-transferases in man using sparteine, caffeine, and paracetamol as probes. Pharmacogenetics 1994: 4, 209-218.
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An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis
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Broly F, Marez D, Sabbagh N, Legrand M, Boone P, Meyer UA. An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis. Pharmacogenetics 1995: 5, 373-384.
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Effective amplification of long targets from cloned inserts and human genomic DNA
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Cheng S, Fockler C, Barnes WM, Higuchi R. Effective amplification of long targets from cloned inserts and human genomic DNA. Proc Natl Acad Sci USA 1994: 91, 5695-5699.
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Nomenclature for human CYP2D6 alleles
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Daly AK, Brockmöller J, Broly F, Eichelbaum M, Evans WE, Gonzalez FJ, Huang J-D, Idle JR, Ingelman-Sundberg M, Ishizaki T, Jacqz-Aigrain E, Meyer UA, Nebert DW, Steen VM, Wolf CR, Zanger UM. Nomenclature for human CYP2D6 alleles. Pharmacogenetics 1996: 6, 193-201.
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5
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0028355764
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Interpretation of a simple PCR analysis of the CYP2D6(A) and CYP2D6(B) null alleles associated with the debrisoquine/ sparteine genetic polymorphism
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Douglas AM, Atchison BA, Somogyi AA, Drummer OH. Interpretation of a simple PCR analysis of the CYP2D6(A) and CYP2D6(B) null alleles associated with the debrisoquine/ sparteine genetic polymorphism. Pharmacogenetics 1994: 4, 154-158.
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0028046321
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Cloning and sequencing of a new non-functional CYT2D6 allele: Deletion of T1795 in exon 3 generates a premature stop codon
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Evert B, Griese E-U, Eichelbaum M. Cloning and sequencing of a new non-functional CYT2D6 allele: Deletion of T1795 in exon 3 generates a premature stop codon. Pharmacogenetics 1994A: 4, 271-274.
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A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine
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Evert B, Griese E-U, Eichelbaum M. A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. Naunyn-Schmiedeberg's Arch Pharmacol 1994B: 350, 434-439.
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Deletion of the entire cytochrome P4502D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/ sparteine polymorphism
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Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA. Deletion of the entire cytochrome P4502D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/ sparteine polymorphism. Am J Hum Genet 1991: 48, 943-950.
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0025080352
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Genotyping of poor metabolizers of debrisoquine by allele specific PCR amplification
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Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
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Johansson I, Lundqvist E, Bertilsson L, Dahl M-L, Sjöqvist F, Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993: 90, 11825-11829.
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Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA. Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine: a study of the functional significance of individual mutations by expression of chimeric genes. J Biol Chem 1990: 265, 17209-17216.
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The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
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Kimura S, Umeno M, Skoda RC, Meyer UA, Gonzalez FJ. The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet 1989: 45, 889-904.
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'It's the genes, stupid': Molecular basis and clinical consequences of genetic cytochrome P4502D6 polymorphism
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A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype
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Marez D, Sabbagh N, Legrand M, Lo-Guidice JM, Boone P, Broly F. A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype. Pharmacogenetics 1995: 5, 305-311.
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Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype
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Saxena R, Shaw GL, Reilling MV, Frame JN, Moir DT, Evans WE, Caporaso N, Weiffenbach B. Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype. Hum Mol Genet 1994: 3, 923-926.
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Two mutant alleles of the human cytochrome P450db1 gene associated with genetically deficient metabolism of debrisoquine and other drugs
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Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology
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Genotyping of the CYP2D6 gene in Norwegian lung cancer patients and controls
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Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism
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