Metabolic activity of dextromethorphan O-demethylation in healthy Japanese volunteers carrying duplicated CYP2D6 genes: Duplicated allele of CYP2D6*10 does not increase CYP2D6 metabolic activity

Clinica Chimica Acta

Volumn 344, Issue 1-2, 2004, Pages 201-204

  Ishiguro, Akihiro ^a   Kubota, Takahiro ^a   Ishikawa, Hiroshi ^b   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b SRL INC   (Japan)

Author keywords

10; CYP2D6; Dextromethorphan; Duplication; Japanese; Phenotyping

Indexed keywords

CYTOCHROME P450 2D6; DEXTROMETHORPHAN;

ADULT; ALLELE; ARTICLE; DEMETHYLATION; FEMALE; GENE DUPLICATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; METABOLIC ACTIVATION; METABOLIC RATE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADULT; BIOTRANSFORMATION; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; DEXTRORPHAN; FEMALE; GENE DOSAGE; GENE DUPLICATION; GENOTYPE; HUMANS; JAPAN; MALE; METHYLATION; MIDDLE AGED; PHARMACOGENETICS;

EID: 2442712928     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cccn.2004.03.002     Document Type: Article

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