Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 1355-1365

  Katnik, Christopher ^a   Guerrero, Waldo R ^a   Pennypacker, Keith R ^a   Herrera, Yelenis ^a   Cuevas, Javier ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; 1,3 DI O TOLYLGUANIDINE; 2 AMINO 5 PHOSPHONOVALERIC ACID; CALCIUM CHANNEL BLOCKING AGENT; GLUCOSE; IBOGAINE; METAPHIT; N [2 (2,3 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; N [2 3,4 DICHLOROPHENYL)ETHYL] N METHYL 2 (DIMETHYLAMINO)ETHYLAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OPIATE AGONIST; OPIATE ANTAGONIST; PENTAZOCINE; PENTOXYVERINE; RUTHENIUM RED; RYANODINE; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; SODIUM AZIDE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; EMBRYO; FLUOROMETRY; IN VITRO STUDY; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; BRAIN ISCHEMIA; CALCIUM; CALCIUM SIGNALING; CEREBRAL CORTEX; CYCLOPENTANES; CYTOPHOTOMETRY; ENZYME INHIBITORS; ETHYLENEDIAMINES; FEMALE; GUANIDINES; MORPHOLINES; NEURONS; PENTAZOCINE; PHENCYCLIDINE; PREGNANCY; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; SODIUM AZIDE; SODIUM CHANNELS; TETRODOTOXIN;

EID: 33751186935     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107557     Document Type: Article

References (40)

1. Ajmo CT Jr, Vernon DO, Collier L, Pennypacker KR, and Cuevas J (2006) Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats. Curr Neurovasc Res 3:89-98.
2. Bowen WD (2000) Sigma receptors: recent advances and new clinical potentials. Pharm Acta Helv 74:211-218.
3. Casellas P, Galiegue S, Bourrie B, Ferrini JB, Jbilo O, and Vidal H (2004) SR31747A: a peripheral sigma ligand with potent antitumor activities. Anticancer Drugs 15:113-118.
4. Cuevas J and Berg DK (1998) Mammalian nicotinic receptors with alpha7 subunits that slowly desensitize and rapidly recover from alpha-bungarotoxin blockade. J Neurosci 18:10335-10344.
5. DeHaven WI and Cuevas J (2004) VPAC receptor modulation of neuroexcitability in intracardiac neurons: dependence on intracellular calcium mobilization and synergistic enhancement by PAC1 receptor activation. J Biol Chem 279:40609-40621.
6. Djali S and Dawson LA (2001) Characterization of endogenous amino acid efflux from hippocampal slices during chemically-induced ischemia. Neurochem Res 26:135-143.
7. Finley M, Fairman D, Liu D, Li P, Wood A, and Cho S (2004) Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury. Brain Res 1001:125-132.
8. Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, and Glossmann H (1996) Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA 93:8072-8077.
9. Hayashi T, Kagaya A, Takebayashi M, Shimizu M, Uchitomi Y, Motohashi N, and Yamawaki S (1995) Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons. J Pharmacol Exp Ther 275:207-214.
10. (2+) concentration. J Pharmacol Exp Ther 293:788-798.
11. Hayashi T and Su TP (2004) Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs 18:269-284.
12. Huettner JE, Stack E, and Wilding TJ (1998) Antagonism of neuronal kainate receptors by lanthanum and gadolinium. Neuropharmacology 37:1239-1247.
13. Klette KL, DeCoster MA, Moreton JE, and Tortella FC (1995) Role of calcium in sigma-mediated neuroprotection in rat primary cortical neurons. Brain Res 704:31-41.
14. Klette KL, Lin Y, Clapp LE, DeCoster MA, Moreton JE, and Tortella FC (1997) Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons. Brain Res 756:231-240.
15. Kume T, Nishikawa H, Taguchi R, Hashino A, Katsuki H, Kaneko S, Minami M, Satoh M, and Akaike A (2002) Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro. Eur J Pharmacol 455:91-100.
16. Lobner D and Lipton P (1990) Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia. Neurosci Lett 117:169-174.
17. Lockhart BP, Soulard P, Benicourt C, Privat A, and Junien JL (1995) Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies. Brain Res 675:110-120.
18. Matsumoto RR, Bowen WD, Tom MA, Vo VN, Truong DD, and De Costa BR (1995) Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. Eur J Pharmacol 280:301-310.
19. Matsumoto RR, Hemstreet MK, Lai NL, Thurkauf A, De Costa BR, Rice KC, Hellewell SB, Bowen WD, and Walker JM (1990) Drug specificity of pharmacological dystonia. Pharmacol Biochem Behav 36:151-155.
20. Mattson MP (2000) Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 1:120-129.
21. McCracken KA, Bowen WD, and Matsumoto RR (1999) Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine. Eur J Pharmacol 365:35-38.
22. Monnet FP, Morin-Surun MP, Leger J, and Combettes L (2003) Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons. J Pharmacol Exp Ther 307:705-712.
23. + currents in rat locus coeruleus neurons induced by experimental ischemia, anoxia, and hypoglycemia. J Neurophysiol 78:2674-2681.
24. Rawls SM, Baron DA, Geller EB, and Adler MW (2002) Sigma sites mediate DTG-evoked hypothermia in rats. Pharmacol Biochem Behav 73:779-786.
25. Robinson HP, Kawahara M, Jimbo Y, Torimitsu K, Kuroda Y, and Kawana A (1993) Periodic synchronized bursting and intracellular calcium transients elicited by low magnesium in cultured cortical neurons. J Neurophysiol 70:1606-1616.
26. Romieu P, Meunier J, Garcia D, Zozime N, Martin-Fardon R, Bowen WD, and Maurice T (2004) The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming. Psychopharmacology (Berl) 175:154-162.
27. Schurr A (2004) Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels. Curr Drug Targets 5:603-618.
28. Senda T, Matsuno K, Okamoto K, Kobayashi T, Nakata K, and Mita S (1996) Ameliorating effect of SA4503, a novel sigma 1 receptor agonist, on memory impairments induced by cholinergic dysfunction in rats. Eur J Pharmacol 315:1-10.
29. Sircar R, Rappaport M, Nichtenhauser R, and Zukin SR (1987) The novel anticonvulsant MK-801: a potent and specific ligand of the brain phencyclidine/sigma-receptor. Brain Res 435:235-240.
30. Soriani O, Vaudry H, Mei YA, Roman F, and Cazin L (1998) Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances. J Pharmacol Exp Ther 286:163-171.
31. Takahashi H, Kirsch JR, Hashimoto K, London ED, Koehler RC, and Traystman RJ (1996) PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke 27:2120-2123.
32. Tanaka E, Yamamoto S, Kudo Y, Mihara S, and Higashi H (1997) Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro. J Neurophysiol 78:891-902.
33. Tang F, Dent EW, and Kalil K (2003) Spontaneous calcium transients in developing cortical neurons regulate axon outgrowth. J Neurosci 23:927-936.
34. 2+-free model of epileptiform activity in rat hippocampal slices. Br J Pharmacol 124:917-929.
35. Vilner BJ and Bowen WD (2000) Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells. J Pharmacol Exp Ther 292:900-911.
36. Walker JM, Bowen WD, Walker FO, Matsumoto RR, De Costa B, and Rice KC (1990) Sigma receptors: biology and function. Pharmacol Rev 42:355-402.
37. Wang GJ and Thayer SA (2002) NMDA-induced calcium loads recycle across the mitochondrial inner membrane of hippocampal neurons in culture. J Neurophysiol 87:740-749.
38. Wang Y and Lee HK (1991) Electrophysiological interactions between NMDA and phencyclidine/sigma receptor agonists and antagonists in Purkinje neurons in the cerebellum of the rat. Neuropharmacology 30:985-994.
39. Zhang H and Cuevas J (2002) Sigma receptors inhibit high-voltage- activated calcium channels in rat sympathetic and parasympathetic neurons. J Neurophysiol 87:2867-2879.
40. Zhang H and Cuevas J (2005) sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons. J Pharmacol Exp Ther 313:1387-1396.