Synthesis and antileishmanial activity of novel 5-(5-nitrofuran-2-y1)-1,3, 4-thiadiazoles with piperazinyl-linked benzamidine substituents

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2602-2608

  Tahghighi, Azar ^a   Marznaki, Farzane Rezazade ^b   Kobarfard, Farzad ^c   Dastmalchi, Siavoush ^a   Mojarrad, Javid Shahbazi ^a   Razmi, Sepideh ^b   Ardestani, Sussan Kabudanian ^b   Emami, Saeed ^d   Shafiee, Abbas ^e   Foroumadi, Alireza ^e  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Benzamidine; In vitro antileishmanial activity; Nitrofuran, 1,3,4 thiadiazole

Indexed keywords

1 (4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL) 4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZINE HYDROCHLORIDE; 1,4,5,6 TETRAHYDRO 2 (4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)PHENYL)PYRIMIDINE HYDROCHLORIDE; 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; BENZAMIDINE DERIVATIVE; DIMINAZENE; IMIDOCARB; MEGLUMINE ANTIMONATE; MORPHOLINO(4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)PHENYL)METHANIMINE HYDROCHLORIDE; N ((TETRAHYDROFURAN 2 YL)METHYL) 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; N (1 BUTYL) 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; N (1 PROPYL) 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1YL)BENZAMIDINE HYDROCHLORIDE; N (2 BUTYL) 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; N (4 METHOXYBENZYL) 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; N BENZYL 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; N ETHYL 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; N METHYL 4 (4 (5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 YL)PIPERAZIN 1 YL)BENZAMIDINE HYDROCHLORIDE; PENTAMIDINE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MACROPHAGE; NONHUMAN; PROMASTIGOTE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZAMIDINES; LEISHMANIA; MACROPHAGES; MICE; MICE, INBRED BALB C; PARASITIC SENSITIVITY TESTS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 79955638456     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.053     Document Type: Article

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