Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3543-3551

  Patrick, Donald A ^a   Bakunov, Stanislav A ^a   Bakunova, Svetlana M ^a   Suresh Kumar, E V K ^a   Chen, Heidi ^a   Jones, Susan Kilgore ^a   Wenzler, Tanja ^b   Barzcz, Todd ^c   Werbovetz, Karl A ^c   Brun, Reto ^b   Tidwell, Richard R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Antileishmanial; Antiplasmodial; Antiprotozoal; Antitrypanosomal; Diamidines; Naphthalene derivatives; Xylene derivatives

Indexed keywords

1,3 BIS(4 AMIDINOPHENOXYMETHYL)BENZENE; 1,3 BIS[4 (N ISOPROPYLAMIDINO)PHENOXYMETHYL]BENZENE; 1,4 BIS(4 AMIDINOPHENOXYMETHYL)BENZENE; 2,5 BIS(4 AMIDINOPHENYL)FURAN; ANTIPROTOZOAL AGENT; ARTEMISININ; BENZENE DERIVATIVE; BENZYL DERIVATIVE; BIS(BENZYLOXY)NAPHTHALENE DERIVATIVE; BIS(PHENOXYMETHYL)BENZENE DERIVATIVE; BIS(PHENOXYMETHYL)NAPHTHALENE DERIVATIVE; CHLOROQUINE; MELARSOPROL; NAPHTHALENE DERIVATIVE; PAFURAMIDINE; PENTAMIDINE; PENTAMIDINE DERIVATIVE; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZENE; CELL SURVIVAL; LEISHMANIA DONOVANI; MICE; MYOBLASTS; NAPHTHALENES; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 67650432150     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.014     Document Type: Article

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