Enhanced recombinant human erythropoietin production by Pichia pastoris in methanol fed-batch/sorbitol batch fermentation through pH optimization

Biochemical Engineering Journal

Volumn 55, Issue 1, 2011, Pages 59-65

  Soyaslan, Elif Şükran ^a   Çalik, Pinar ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

AOX; Erythropoietin; Methanol; PH; Pichia pastoris; Sorbitol

Indexed keywords

AOX; BATCH FERMENTATION; CELL CONCENTRATIONS; CONSUMPTION RATES; ERYTHROPOIETIN; EXTRACELLULAR PROTEASE; FED BATCHES; HUMAN ERYTHROPOIETIN; OXYGEN DEMAND; PH OPTIMIZATION; PICHIA PASTORIS; RECOMBINANT PROTEIN PRODUCTIONS; SORBITOL; THREE PHASIS;

GLYCEROL; METHANOL; OXYGEN;

PH EFFECTS;

ALCOHOL OXIDASE; CARBOXYLIC ACID; METHANOL; PROTEINASE; RECOMBINANT ERYTHROPOIETIN; SORBITOL;

ARTICLE; BIOPROCESS; BIOREACTOR; CELL GROWTH; CYTOKINE PRODUCTION; ENZYME SYNTHESIS; FED BATCH FERMENTATION; GROWTH RATE; NONHUMAN; OXYGEN CONSUMPTION; PH; PICHIA PASTORIS; PRIORITY JOURNAL;

PICHIA PASTORIS;

EID: 79955637772     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2011.03.007     Document Type: Article

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