Fermentation and oxygen transfer characteristics in recombinant human growth hormone production by Pichia pastoris in sorbitol batch and methanol fed-batch operation

Journal of Chemical Technology and Biotechnology

Volumn 85, Issue 2, 2010, Pages 226-233

  Çalik, Pinar ^a   Inankur, Bahar ^a   Soyaslan, Elif Ş ^a   Şahin, Merve ^a   Taşpinar, Hatice ^a   Açik, Eda ^a   Bayraktar, Eda ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Feeding rate; Human growth hormone; Methanol; Oxygen transfer; P. pastoris; Sorbitol

Indexed keywords

BIOPROCESSES; CELL SYNTHESIS; EXTRACELLULAR PROTEASE; FED-BATCH OPERATION; FEED-RATES; FEEDING RATE; FEEDING STRATEGIES; HUMAN GROWTH HORMONE; LIMITING VALUES; MAXIMUM VALUES; METHANOL FEED; OXYGEN TRANSFER; OXYGEN TRANSFER CHARACTERISTICS; OXYGEN UPTAKE RATES; P. PASTORIS; PICHIA PASTORIS; RECOMBINANT HUMAN GROWTH HORMONE (RHGH); RECOMBINANT HUMAN GROWTH HORMONES; SPECIFIC GROWTH RATE; TWO STAGE;

FEEDING; FERMENTATION; GROWTH KINETICS; METHANOL; OXYGEN;

CHEMICAL ANALYSIS;

ALCOHOL OXIDASE; HUMAN GROWTH HORMONE; METHANOL; PROTEINASE; SORBITOL;

ARTICLE; BATCH REACTOR; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; EXTRACELLULAR SPACE; FED BATCH FERMENTATION; FERMENTATION MEDIUM; FUNGAL CELL; FUNGAL METABOLISM; FUNGUS GROWTH; GROWTH RATE; GROWTH REGULATION; HORMONE SYNTHESIS; NONHUMAN; NUTRIENT UPTAKE; OXYGEN TRANSPORT; PICHIA PASTORIS; PROTEIN INDUCTION;

PICHIA PASTORIS;

EID: 75149145634     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.2292     Document Type: Article

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