Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6- (4′-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2109-2116

  Karki, Subhas S ^a,b   Panjamurthy, Kuppusamy ^a   Kumar, Sujeet ^b   Nambiar, Mridula ^a   Ramareddy, Sureshbabu A ^b   Chiruvella, Kishore K ^a   Raghavan, Sathees C ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b A Constituent Unit of KLE Academy of Higher Education Research   (India)

Author keywords

Anticancer drugs; Apoptosis; Cancer therapeutics; Cell death; Cytotoxicity; Double strand breaks

Indexed keywords

2 (4 BROMOBENZYL) 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 CHLOROBENZYL) 5 BROMO 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 CHLOROBENZYL) 5 FORMYL 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 CHLOROBENZYL) 5 THIOCYANATO 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 CHLOROBENZYL) 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 FLUOROBENZYL) 5 BROMO 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 FLUOROBENZYL) 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 METHYLBENZYL) 5 BROMO 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (4 METHYLBENZYL) 5 THIOCYANATO 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 AMINO 5 (4 BROMOBENZYL) 1,3,4 THIADIAZOLE; 2 AMINO 5 (4 CHLOROBENZYL) 1,3,4 THIADIAZOLE; 2 AMINO 5 (4 FLUOROBENZYL) 1,3,4 THIADIAZOLE; 2 AMINO 5 (4 METHYLBENZYL) 1,3,4 THIADIAZOLE; 2 BENZYL 5 BROMO 6 (4' FLUOROPHENYL) IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 BENZYL 5 FORMYL 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 BENZYL 5 THIOCYANATO 6 (4' FLUOROPHENYL) IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 BENZYL 6 (4' FLUOROPHENYL) IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; ANTINEOPLASTIC AGENT; FLUOROURACIL; IMIDAZO[2,1 B]THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG SCREENING; IC 50; LEUKEMIA CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLES; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TUMOR CELLS, CULTURED;

EID: 79955630726     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.064     Document Type: Article

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