Regulation of tissue plasminogen activator/plasminogen activator inhibitor-1 by hydrocortisone in rat primary astrocytes

Journal of Neuroscience Research

Volumn 89, Issue 7, 2011, Pages 1059-1069

  Kwon, Kyoung Ja ^a,b   Cho, Kyu Suk ^a,b   Lee, Sung Hoon ^a,b   Kim, Jung Nam ^a,b   Joo, So Hyun ^a,b   Ryu, Jong Hoon ^c   Ignarro, Louis J ^b,d   Han, Seol Heui ^a,b   Young Shin, Chan ^a,b  

^a Konkuk University   (South Korea)

^b Konkuk University   (South Korea)

^c Kyung Hee University   (South Korea)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Astrocytes; Inflammation; Neuroprotection; PAI 1; TPA

Indexed keywords

CYCLOOXYGENASE 2; GLUTAMIC ACID; HYDROCORTISONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CELL CULTURE; DOWN REGULATION; ENZYME ACTIVITY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; GLUTAMIC ACID; HYDROCORTISONE; NEUROTOXINS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TISSUE PLASMINOGEN ACTIVATOR; UP-REGULATION;

EID: 79955623407     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22619     Document Type: Article

References (61)

1. Adibhatla RM, Hatcher JF. 2008. Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS Neurol Disord Drug Targets 7: 243-253.
2. Akiyama H, Arai T, Kondo H, Tanno E, Haga C, Ikeda K. 2000. Cell mediators of inflammation in the Alzheimer disease brain. Alzheimer Dis Assoc Disord 14( Suppl 1): S47-S53.
3. Andreasen PA, Georg B, Lund LR, Riccio A, Stacey SN. 1990. Plasminogen activator inhibitors: hormonally regulated serpins. Mol Cell Endocrinol 68: 1-19.
4. Ayachi SE, Paulmyer-Lacroix O, Verdier M, Alessi MC, Dutour A, Grino M. 2006. 11Beta-hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese women. J Thromb Haemost 4: 621-627.
5. Bator JM, Cohen RL, Chambers DA. 1998. Hydrocortisone regulates the dynamics of plasminogen activator and plasminogen activator inhibitor expression in cultured murine keratinocytes. Exp Cell Res 242: 110-119.
6. Beach TG, Walker R, McGeer EG. 1989. Patterns of gliosis in Alzheimer's disease and aging cerebrum. Glia 2: 420-436.
7. Belanger M, Magistretti PJ. 2009. The role of astroglia in neuroprotection. Dialogues Clin Neurosci 11: 281-295.
8. Benarroch EE. 2007. Tissue plasminogen activator: beyond thrombolysis. Neurology 69: 799-802.
9. Bergami M, Santi S, Formaggio E, Cagnoli C, Verderio C, Blum R, Berninger B, Matteoli M, Canossa M. 2008. Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes. J Cell Biol 183: 213-221.
10. Berger P, Kozlov SV, Cinelli P, Kruger SR, Vogt L, Sonderegger P. 1999. Neuronal depolarization enhances the transcription of the neuronal serine protease inhibitor neuroserpin. Mol Cell Neurosci 14: 455-467.
11. Cadet JL, Krasnova IN. 2009. Cellular and molecular neurobiology of brain preconditioning. Mol Neurobiol 39: 50-61.
12. Cervos-Navarro J, Lafuente JV. 1991. Traumatic brain injuries: structural changes. J Neurol Sci 103( Suppl): S3-S14.
13. Cheng YC, Chen LM, Chang MH, Chen WK, Tsai FJ, Tsai CH, Lai TY, Kuo WW, Huang CY, Liu CJ. 2009. Lipopolysaccharide up-regulates uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 cardiomyoblast cells. Mol Cell Biochem 325: 15-23.
14. Choi SH, Lee DY, Kim SU, Jin BK. 2005. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase. J Neurosci 25: 4082-4090.
15. Darlington CL. 2005. Astrocytes as targets for neuroprotective drugs. Curr Opin Invest Drugs 6: 700-703.
16. Das F, Ghosh-Choudhury N, Venkatesan B, Li X, Mahimainathan L, Choudhury GG. 2008. Akt kinase targets association of CBP with SMAD 3 to regulate TGFbeta-induced expression of plasminogen activator inhibitor-1. J Cell Physiol 214: 513-527.
17. Dhandapani KM, Mahesh VB, Brann DW. 2003. Astrocytes and brain function: implications for reproduction. Exp Biol Med 228: 253-260.
18. Dinkel K, Ogle WO, Sapolsky RM. 2002. Glucocorticoids and central nervous system inflammation. J Neurovirol 8: 513-528.
19. Docagne F, Nicole O, Marti HH, MacKenzie ET, Buisson A, Vivien D. 1999. Transforming growth factor-beta1 as a regulator of the serpins/t-PA axis in cerebral ischemia. FASEB J 13: 1315-1324.
20. Emeis JJ, Kooistra T. 1986. Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells. J Exp Med 163: 1260-1266.
21. Eng LF, Yu AC, Lee YL. 1992. Astrocytic response to injury. Prog Brain Res 94: 353-365.
22. Gelehrter TD, Sznycer-Laszuk R, Zeheb R, Cwikel BJ. 1987. Dexamethasone inhibition of tissue-type plasminogen activator (tPA) activity: paradoxical induction of both tPA antigen and plasminogen activator inhibitor. Mol Endocrinol 1: 97-101.
23. Green SJ, Mellouk S, Hoffman SL, Meltzer MS, Nacy CA. 1990. Cellular mechanisms of nonspecific immunity to intracellular infection: cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytes. Immunol Lett 25: 15-19.
24. Griffin WS, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, Roberts GW, Mrak RE. 1998. Glial-neuronal interactions in Alzheimer's disease: the potential role of a "cytokine cycle" in disease progression. Brain Pathol 8: 65-72.
25. Gualandris A, Jones TE, Strickland S, Tsirka SE. 1996. Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator. J Neurosci 16: 2220-2225.
26. Hamilton JA, Whitty GA, Wojta J, Gallichio M, McGrath K, Ianches G. 1993. Regulation of plasminogen activator inhibitor-1 levels in human monocytes. Cell Immunol 152: 7-17.
27. Hansen MB, Nielsen SE, Berg K. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119: 203-210.
28. Hardin-Pouzet H, Giraudon P, Belin MF, Didier-Bazes M. 1996. Glucocorticoid upregulation of glutamate dehydrogenase gene expression in vitro in astrocytes. Brain Res Mol Brain Res 37: 324-328.
29. Hastings GA, Coleman TA, Haudenschild CC, Stefansson S, Smith EP, Barthlow R, Cherry S, Sandkvist M, Lawrence DA. 1997. Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival. J Biol Chem 272: 33062-33067.
30. Heaton JH, Kathju S, Gelehrter TD. 1992. Transcriptional and posttranscriptional regulation of type 1 plasminogen activator inhibitor and tissue-type plasminogen activator gene expression in HTC rat hepatoma cells by glucocorticoids and cyclic nucleotides. Mol Endocrinol 6: 53-60.
31. Kariko K, Weissman D, Welsh FA. 2004. Inhibition of toll-like receptor and cytokine signaling-a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab 24: 1288-1304.
32. Kathju S, Heaton JH, Bruzdzinski CJ, Gelehrter TD. 1994. Synergistic induction of tissue-type plasminogen activator gene expression by glucocorticoids and cyclic nucleotides in rat HTC hepatoma cells. Endocrinology 135: 1195-1204.
33. Kim SD, Yang SI, Kim HC, Shin CY, Ko KH. 2007. Inhibition of GSK-3beta mediates expression of MMP-9 through ERK1/2 activation and translocation of NF-kappaB in rat primary astrocyte. Brain Res 1186: 12-20.
34. Kimura H, Li X, Torii K, Okada T, Kamiyama K, Mikami D, Takahashi N, Yoshida H. 2009. Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells. Nephrol Dial Transplant 24: 1759-1765.
35. Krueger SR, Ghisu GP, Cinelli P, Gschwend TP, Osterwalder T, Wolfer DP, Sonderegger P. 1997. Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci 17: 8984-8996.
36. Lee SY, Kim HJ, Lee WJ, Joo SH, Jeon SJ, Kim JW, Kim HS, Han SH, Lee J, Park SH, Cheong JH, Kim WK, Ko KH, Shin CY. 2008. Differential regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by the cyclic-AMP system in lipopolysaccharide-stimulated rat primary astrocytes. Neurochem Res 33: 2324-2334.
37. Lee WJ, Shin CY, Yoo BK, Ryu JR, Choi EY, Cheong JH, Ryu JH, Ko KH. 2003. Induction of matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide-stimulated primary astrocytes is mediated by extracellular signal-regulated protein kinase 1/2 (Erk1/2). Glia 41: 15-24.
38. Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, Nodin C, Stahlberg A, Aprico K, Larsson K, Yabe T, Moons L, Fotheringham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M, Pekny M. 2008. Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab 28: 468-481.
39. Liang MH, Wendland JR, Chuang DM. 2008. Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci 37: 440-453.
40. Liu XQ, Sheng R, Qin ZH. 2009. The neuroprotective mechanism of brain ischemic preconditioning. Acta Pharmacol Sin 30: 1071-1080.
41. Lochner JE, Honigman LS, Grant WF, Gessford SK, Hansen AB, Silverman MA, Scalettar BA. 2006. Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging. J Neurobiol 66: 564-577.
42. Marsh B, Stevens SL, Packard AE, Gopalan B, Hunter B, Leung PY, Harrington CA, Stenzel-Poore MP. 2009. Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: a critical role for IRF3. J Neurosci 29: 9839-9849.
43. Masos T, Miskin R. 1997. mRNAs encoding urokinase-type plasminogen activator and plasminogen activator inhibitor-1 are elevated in the mouse brain following kainate-mediated excitation. Brain Res Mol Brain Res 47: 157-169.
44. Park GH, Ryu JR, Shin CY, Choi MS, Han BH, Kim WK, Kim HC, Ko KH. 2006. Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes. Neurosci Res 54: 15-23.
45. Pekny M, Wilhelmsson U, Bogestal YR, Pekna M. 2007. The role of astrocytes and complement system in neural plasticity. Int Rev Neurobiol 82: 95-111.
46. Rao JS, Rayford A, Morantz RA, Festoff BW, Sawaya R. 1993. Increased levels of plasminogen activator inhibitor-1 (PAI-1) in human brain tumors. J Neurooncol 17: 215-221.
47. Rosenfeld BA, Nguyen ND, Sung I, Faraday N. 1998. Neuroendocrine stress hormones do not recreate the postoperative hypercoagulable state. Anesth Analg 86: 640-645.
48. Salonen EM, Vaheri A, Pollanen J, Stephens R, Andreasen P, Mayer M, Dano K, Gailit J, Ruoslahti E. 1989. Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin. J Biol Chem 264: 6339-6343.
49. Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. 2010. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci 30: 5843-5854.
50. Sheehan JJ, Tsirka SE. 2005. Fibrin-modifying serine proteases thrombin, tPA, and plasmin in ischemic stroke: a review. Glia 50: 340-350.
51. Shin CY, Choi JW, Ryu JR, Ko KH, Choi JJ, Kim HS, Lee JC, Lee SJ, Kim HC, Kim WK. 2002. Glucose deprivation decreases nitric oxide production via NADPH depletion in immunostimulated rat primary astrocytes. Glia 37: 268-274.
52. Shin CY, Kundel M, Wells DG. 2004. Rapid, activity-induced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation. J Neurosci 24: 9425-9433.
53. Skrzypiec AE, Buczko W, Pawlak R. 2008. Tissue plasminogen activator in the amygdala: a new role for an old protease. J Physiol Pharmacol 59( Suppl 8): 135-146.
54. Stutz A, Conne B, Huarte J, Gubler P, Volkel V, Flandin P, Vassalli JD. 1998. Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. Genes Dev 12: 2535-2548.
55. Uno S, Nakamura M, Ohomagari Y, Matsuyama S, Seki T, Ariga T. 1998. Regulation of tissue-type plasminogen activator (tPA) and type-1 plasminogen activator inhibitor (PAI-1) gene expression in rat hepatocytes in primary culture. J Biochem 123: 806-812.
56. Wen FQ, Kohyama T, Skold CM, Zhu YK, Liu X, Romberger DJ, Stoner J, Rennard SI. 2003. Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts. Inflammation 27: 9-19.
57. Wickert L, Chatain N, Kruschinsky K, Gressner AM. 2007. Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytes. Comp Hepatol 6: 5.
58. Yepes M, Lawrence DA. 2004. Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system? Trends Cardiovasc Med 14: 173-180.
59. Zhang Y, Zhang J, Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF, John GR. 2010. TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation. Glia 58: 964-974.
60. Zicari A, Ticconi C, Realacci M, Cela O, Santangelo C, Pietropolli A, Russo MA, Piccione E. 2002. Hormonal regulation of cytokine release by human fetal membranes at term gestation: effects of oxytocin, hydrocortisone and progesterone on tumour necrosis factor-alpha and transforming growth factor-beta 1 output. J Reprod Immunol 56: 123-136.
61. Zschocke J, Bayatti N, Clement AM, Witan H, Figiel M, Engele J, Behl C. 2005. Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions. J Biol Chem 280: 34924-34932.