Dexamethasone enhances basal and TNF-α-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11β-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells

Nephrology Dialysis Transplantation

Volumn 24, Issue 6, 2009, Pages 1759-1765

  Kimura, Hideki ^a   Li, Xuan ^a   Torii, Kunio ^b   Okada, Toshiharu ^b   Kamiyama, Kazuko ^a   Mikami, Daisuke ^a   Takahashi, Naoki ^a   Yoshida, Haruyoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b UNIVERSITY OF FUKUI HOSPITAL   (Japan)

Author keywords

Dexamethasone; Human proximal tubular cells; PAI 1; TNF

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALDOSTERONE; CORTICOSTEROID; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; HERBIMYCIN A; MESSENGER RNA; MIFEPRISTONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SPIRONOLACTONE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BASEMENT MEMBRANE; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOSTIMULATION; INFLAMMATION; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ALDOSTERONE; CELLS, CULTURED; DEXAMETHASONE; FIBROSIS; HUMANS; KIDNEY TUBULES, PROXIMAL; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN-TYROSINE KINASES; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; TYRPHOSTINS;

EID: 67651113986     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn756     Document Type: Article

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