Glucose deprivation decreases nitric oxide production via NADPH depletion in immunostimulated rat primary astrocytes

GLIA

Volumn 37, Issue 3, 2002, Pages 268-274

  Chan, Young Shin ^a   Ji, Woong Choi ^a   Jae, Ryun Ryu ^a   Kwang, Ho Ko ^a   Choi, Jung Jin ^b   Kim, Hyun Soo ^b   Kim, Hee Sun ^b   Lee, Jae Chul ^b   Lee, Sun Jung ^b   Hyoung, Chun Kim ^c   Kim, Won Ki ^b  

^a Seoul National University   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

Cell death; Cofactor; Glutathione; iNOS; Tetrahydrobiopterine

Indexed keywords

5,6,7,8-TETRAHYDROBIOPTERIN; BIOPTERIN; DEOXYGLUCOSE; DRUG DERIVATIVE; GAMMA INTERFERON; GLUCOSE; GLUTATHIONE; IMMUNOLOGICAL ADJUVANT; LACTIC ACID; LIPOPOLYSACCHARIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PYRUVIC ACID; TETRAHYDROBIOPTERIN;

ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; CENTRAL NERVOUS SYSTEM; CYTOLOGY; DEGENERATIVE DISEASE; DOWN REGULATION; DRUG EFFECT; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; NEWBORN; RAT; SPRAGUE DAWLEY RAT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BIOPTERIN; CELL DEATH; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; DEOXYGLUCOSE; DOWN-REGULATION; GLUCOSE; GLUTATHIONE; INTERFERON TYPE II; LACTIC ACID; LIPOPOLYSACCHARIDES; NADP; NEURODEGENERATIVE DISEASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036509898     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10032     Document Type: Article

References (40)

1. Reactive nitrogen intermediates in human neuropathology: An overview
2. The importance of nitric oxide in the cytokine-induced inhibition of glucose formation by cultured hepatocytes incubated with insulin, dexamethasone, and glucagon
3. Potentiated glucose deprivation-induced death of astrocytes after induction of iNOS
4. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells
5. The use of monochlorobimane to determine hepatic GSH levels and synthesis
6. Peroxynitrite formation in focal cerebral ischemia-reperfusion in rats occurs predominantly in the peri-infarct region
7. Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultured rat astrocytes
8. Calcium-independent NO-synthase activity and nitrites/nitrates production in transient focal cerebral ischaemia in mice
9. Cellular mechanisms of nonspecific immunity to intracellular infection: Cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytes
10. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle
11. Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia
12. Co-induction of nitric oxide and tetrahydrobiopterin synthesis in the myocardium in vivo
13. Inhibition of hepatic gluconeogenesis by nitric oxide: A comparison with endotoxic shock
14. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
15. Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: Correlation with mitochondrial dysfunction and subsequent cell death
16. Nitric oxide production during focal cerebral ischemia in rats
17. Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture
18. Immunostimulated glial cells potentiate glucose deprivation-induced death of cultured rat cerebellar granule cells
19. Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats
20. The detoxification of cumene hydroperoxide by the glutathione system of cultured astroglial cells hinges on hexose availability for the regeneration of NADPH
21. Acute hyperglycemia depresses arteriolar NO formation in skeletal muscle
22. Augmentation effects of high glucose on endotoxin-induced nitric oxide production in murine macrophages
23. Production of nitric oxide by glial cells: Regulation and potential roles in the CNS
24. Glucose-induced down-regulation of NO production and inducible NOS expression in cultured rat aortic vascular smooth muscle cells: Role of protein kinase C
25. Glucose and pyruvate regulate cytokine-induced nitric oxide production by cardiac myocytes
26. Profiles of cortical tissue depolarization in cat focal cerebral ischemia in relation to calcium ion homeostasis and nitric oxide production
27. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat
28. Glutathione-dependent protection against oxidative injury
29. Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels: Possible mediation via protein kinase C
30. Roles for protein kinases in the induction of nitric oxide synthase in astrocytes
31. Measurement of protein using bicinchoninic acid
32. Inducible nitric oxide synthase in the central nervous system
33. L-arginine-induced regional cerebral blood flow increase is abolished after transient focal cerebral ischemia in the rat
34. Nitric oxide inhibits glycogen synthesis in isolated rat hepatocytes
35. Potentiation of nitric oxide formation following bilateral carotid occlusion and focal cerebral ischemia in the rat: In vivo detection of the nitric oxide radical by electron paramagnetic resonance spin trapping
36. High glucose inhibits nitric oxide production in cultured rat mesangial cells
37. High glucose enhances growth factor-stimulated nitric oxide production by cultured rat mesangial cells
38. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
39. Effect of serum in medium on the expression of inducible nitric oxide synthase and superoxide dismutases in cultured C6 glioma cells
40. Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion