Nutrigenetics of the postprandial lipoprotein metabolism: Evidences from human intervention studies

Current Vascular Pharmacology

Volumn 9, Issue 3, 2011, Pages 287-291

  Perez Martinez, Pablo ^a   Garcia Rios, Antonio ^a   Delgado Lista, Javier ^a   Perez Jimenez, Francisco ^a   Lopez Miranda, Jose ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

GCKR gene; Gene diet interaction; Nutrigenetics; Polymorphism; Postprandial lipemia; Triglycerides

Indexed keywords

APOLIPOPROTEIN A5; GLUCOKINASE REGULATORY PROTEIN; NUTRACEUTICAL; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR RISK; DIET RESTRICTION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HAPLOTYPE; HEREDITY; HUMAN; HYPERLIPIDEMIA; LIPOPROTEIN METABOLISM; NUTRITION; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; CARDIOVASCULAR DISEASES; DIETARY FATS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERLIPIDEMIAS; HYPERTRIGLYCERIDEMIA; LIPOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTPRANDIAL PERIOD; RISK FACTORS;

EID: 79955617171     PISSN: 15701611     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016111795495495     Document Type: Article

References (46)

1. Le NA, Walter MF. The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep 2007; 9: 110-5.
2. Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation 1979; 60: 473-85.
3. Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with non-fasting triglycerides and risk of cardiovascular events in women. JAMA 2007; 298: 309-16.
4. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007; 298: 299-308.
5. Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F, Ordovas JM. Influence of genetic factors in the modulation of postprandial lipemia. Atheroscler Suppl 2008; 9: 49-55.
6. Pennacchio LA, Olivier M, Hubacek JA, et al. An apolipoprotein influencing triacylglycerols in humans and mice revealed by comparative sequencing. Science 2001; 294: 169-73.
7. Van der Vliet HN, Sammels MG, Leegwater AC, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J Biol Chem 2001; 276: 44512-20.
8. Ribalta J, Figuera L, Fernandez-Ballart J, et al. Newly identified apolipoprotein AV gene predisposes to high plasma triacylglycerols in familial combined hyperlipidemia. Clin Chem 2002; 48: 1597-600.
9. Fruchart-Najib J, Bauge E, Niculescu LS, et al. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem Biophys Res Commun 2004; 319: 397-404.
10. Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM, Cohen JC. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet 2002; 11: 3031-8.
11. Martin S, Nicaud V, Humphiries E, Talmud PJ. Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochim Biophys Acta 2003; 1637: 217-25.
12. Talmud PJ, Hawe E, Martin S, et al. Relative contribution of variation within the APOC3/A4/AV gene cluster in determining plasma triglycerides. Hum Mol Genet 2002; 11: 3039-46.
13. Aouizerat BE, Kulkarni M, Heilbron D, et al. Genetic Analysis of a Polymorphism in the Human Apolipoprotein A-V Gene: Effect on Plasma Lipids. J Lipid Res 2003; 44: 1167-73.
14. Melissa AA, Philippa JT, Federico MF, Deborah A. Association of apolipoprotein A5 variants with LDL particle size and triacylglycerol in Japanese Americans. Biochim Biophys Acta 2004; 1688: 1-9.
15. Szalai C, Keszei M, Duba J, et al. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Atherosclerosis 2004; 173: 109-14.
16. Dallongeville J, Cottel D, Montaye M, Codron V, Amouyel P, Helbecque N. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Int J Cardiol 2006; 106: 152-6.
17. Moreno R, Perez-Jimenez F, Marin C, et al. A single nucleotide polymorphism of the apolipoprotein A-V gene-1131T>C modulates postprandial lipoprotein metabolism. Atherosclerosis 2006; 189: 163-8.
18. Masana L, Ribalta J, Salazar J, Fernandez-Ballart J, Joven J, Cabezas MC. The Apolipoprotein A-V gene and diurnal triglyceridaemia in normolipidaemic subjects. Clin Chem Lab Med 2003; 41: 517-21.
19. Jang Y, Kim JY, Kim OY, et al. The-1131T>C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; anda oxidative stress in non-obese Korean men. Am J Clin Nutr 2004; 80: 832-40.
20. Olano-Martin E, Abraham EC, Gill-Garrison R, et al. Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. J Lipid Res 2008; 49: 945-53.
21. Ishihara M, Kujiraoka T, Iwasaki T, et al. A sandwich enzymelinked immunosorbent assay for human plasma apolipoprotein A-V concentration. J Lipid Res 2005; 46: 2015-22.
22. Grosskopf I, Baroukh N, Lee SJ, et al. Apolipoprotein A-V deficiency results in marked hypertriglyceridemia attributable to decreased lipolysis of triglyceride-rich lipoproteins and removal of their remnants. Arterioscler Thromb Vasc Biol 2005; 25: 2573-9.
23. Kim JY, Kim OY, Koh SJ, et al. Comparison of low-fat meal and high-fat meal on postprandial lipemic response in non-obese men according to the-1131T>C polymorphism of the apolipoprotein A5 (APOA5) gene (randomized cross-over design). J Am Coll Nutr 2006; 25: 340-7.
24. Moreno R, Perez-Jimenez F, Marin C, et al. Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. J Clin Endocrinol Metab 2007; 92: 2280-5.
25. Trichopoulou A, Yiannakouris N, Bamia C, Benetou V, Trichopoulos D, Ordovas JM. Genetic predisposition, non-genetic risk factors, and coronary infarct. Arch Intern Med 2008; 168: 891-6.
26. Morrison AC, Bare LA, Chambless LE, et al. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 2007; 166: 28-35.
27. Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316: 1331-6.
28. Orho-Melander M, Melander O, Guiducci C, et al. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 2008; 57: 3112-21.
29. Ferre T, Riu E, Bosch F, Valera A. Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver. Faseb J 1996; 10: 1213-8.
30. O'Doherty RM, Lehman DL, Telemaque-Potts S, Newgard CB. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes 1999; 48: 2022-7.
31. Slosberg ED, Desai UJ, Fanelli B, et al. Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein. Diabetes 2001; 50: 1813-20.
32. Perez-Martinez P, Corella D, Shen J, et al. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. Am J Clin Nutr 2009; 89: 391-9.
33. Servetnick DA, Brasaemle DL, Gruia-Gray J, Kimmel AR, Wolff J, Londos C. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells. J Biol Chem 1995; 270: 16970-3.
34. Brasaemle DL, Rubin B, Harten IA, Gruia-Gray J, Kimmel AR, Londos C. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem 2000; 275: 38486-93.
35. Tansey JT, Huml AM, Vogt R, et al. Functional studies on native and mutated forms of perilipins. A role in protein kinase Amediated lipolysis of triacylglycerols. J Biol Chem 2003; 278: 8401-6.
36. Sztalryd C, Xu G, Dorward H, et al. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol 2003; 161: 1093-103.
37. Nishiu J, Tanaka T, Nakamura Y. Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method. Genomics 1998; 48: 254-7.
38. Duggirala R, Blangero J, Almasy L, et al. A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am J Hum Genet 2000; 66: 1237-45.
39. Mori Y, Otabe S, Dina C, et al. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 2002; 51: 1247-55.
40. Qi L, Corella D, Sorli JV, et al. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clin Genet 2004; 66: 299-310.
41. Qi L, Shen H, Larson I, et al. Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes Res 2004; 12: 1758-65.
42. Deram S, Nicolau CY, Perez-Martinez P, et al. Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. J Clin Endocrinol Metab 2008; 93: 4933-40.
43. Qi L, Tai ES, Tan CE, et al. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J Mol Med 2005; 83: 448-56.
44. Perez-Martinez P, Yiannakouris N, Lopez-Miranda J, et al. Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations. Am J Clin Nutr 2008; 87: 744-52.
45. Mottagui-Tabar S, Ryden M, Lofgren P, et al. Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Diabetologia 2003; 46: 789-97.
46. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001; 29: 306-9.