A major susceptibility locus influencing plasma triglyceride concentrations is located chromosome 15q in Mexican Americans

American Journal of Human Genetics

Volumn 66, Issue 4, 2000, Pages 1237-1245

  Duggirala, Ravindranath ^a,b   Blangero, John ^c   Almasy, Laura ^c   Dyer, Thomas D ^c   Williams, Kenneth L ^a   Leach, Robin J ^b   O'Connell, Peter ^d   Stern, Michael P ^a  

^a University of Texas Health Science Center   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHROMOSOME 15Q; CHROMOSOME 7; FEMALE; GENE LOCATION; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0033942570     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302849     Document Type: Article

References (63)

1. Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, et al (1999) Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 21:76-83
2. Allison DB, Neale MC, Zannolli R, Schork NJ, Amos CI, Blangero J (1999) Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait locimapping procedure. Am J Hum Genet 65:531-544
3. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62: 1198-1211
4. Almasy L, Hixson JE, Rainwater DL, Cole S, Williams JT, Mahaney MC, VandeBerg JL, et al (1999) Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism. Am J Hum Genet 64:1686-1693
5. Amos CI (1994) Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54: 535-543
6. Arya R, Duggirala R, Almasy L, Stern MP, O'Connell P, Blangero J (1999) Strong evidence for linkage of high-density lipoprotein cholesterol (HDL-C) concentrations to a genetic location on chromosome 9p in Mexican Americans. Am J Hum Genet Suppl 65:A2
7. Austin MA, Hokanson JE, Edwards KL (1998) Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 81(4A):7B-12B
8. Beaty TH, Self SG, Liang KY, Connolly MA, Chase GA, Kwiterovich PO (1985) Use of robust variance components models to analyze triglyceride data in families. Ann Hum Genet 49:315-328
9. Blangero J, Almasy L (1997) Multipoint oligogenic linkage analysis of quantitative traits. Genet Epidemiol 14:959-964
10. Cox NJ, Bell GI (1989) Disease associations: chance, artifact, or susceptibility genes? Diabetes 38:947-950
11. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, P. O'Connell, et al (1999) Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 64:1127-1140
12. Duggirala R, Stern MP, Mitchell BD, Reinhart LJ, Shipman PA, Uresandi OC, Chung WK, et al (1996) Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am J Hum Genet 59:694-703
13. Dyke B (1996) PEDSYS: a pedigree data management system: version 2.0: user's manual (PGL Technical Report no. 2), Population Genetics Laboratory, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio
14. Ehrenborg E, Clee SM, Pimstone SN, Reymer PWA, Benlian P, Hoogendijk CF, Davis HJ, et al (1997) Ethnic variation and in vivo effects of the - 93t-→g promoter variant in the lipoprotein lipase gene. Arterioscler Thromb Vasc Biol 17: 2672-2678
15. Elston RC (1998) Methods of linkage analysis-and the assumptions underlying them. Am J Hum Genet 63:931-934
16. Fasman KH, Letovsky SI, Cottingham RW, Kingsbury DT (1996) Improvements to the GBD™ Human Genome Data Base. Nucleic Acids Res 24:57-63
17. Fernández-Ruiz E, Armesilla AL, Sánchez-Madrid F, Vega MA (1993) Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. Genomics 17:759-761
18. Fulker DW, Cherny SS, Cardon LR (1995) Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet 56:1224-1233
19. Garg A (1998) Treatment of diabetic dyslipidemia. Am J Cardiol 81(4A):47B-51B
20. Gerdes C, Gerdes LU, Hansen PS, Faergeman O (1995) Polymorphisms in the lipoprotein lipase gene and their associations with plasma lipid concentrations in 40-year-old Danish men. Circulation 92:1765-1769
21. Ginsberg HN (1996) Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels. Diabetes 45(Suppl 3):S27-S30
22. Gorry MC, Gabbaizedeh D, Furey W, Gates LK Jr, Preston RA, Aston CE, Zhang Y, et al (1997) Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology 113:1063-1068
23. Gotto AM (1998) Triglyceride: the forgotten risk factor. Circulation 97:1027-1028
24. Grundy SM (1998) Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome. Am J Cardiol 81(4A): 18B-25B
25. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK (1990) Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 263: 2893-2898
26. Haffner SM, Stern MP, Hazuda HP, Pugh JA, Patterson JK (1986) Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. N Engl J Med 315: 220-224
27. Havel RJ (1998) Plasma triglycerides and the clinician: time for reassessment. J Am Coll Cardiol 31:1258-1259
28. Hegele RA, Connelly PW, Hanley AJG, Sun F, Harris SB, Zinman B (1997) Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins. Arterioscler Thromb Vasc Biol 17:2753-2758
29. Howard BV (1996) Macrovascular complications of diabetes mellitus. In: LeRoith D, Taylor SI, Olefsky JM (eds) Diabetes mellitus. Lippincott-Raven, Philadelphia, pp 792-797
30. Hsueh WA, Law RE (1998) Cardiovascular risk continuum: implications of insulin resistance and diabetes. Am J Med 105(1A):4S-14S
31. Humphries SE, Nicaud V, Margalef J, Tiret L, Talmud PJ, for the EARS (1998) Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). Arterioscler Thromb Vasc Biol 18:526-534
32. Iselius L (1988) Genetic epidemiology of common diseases in humans. In: Weir BS, Eisen EJ, Goodman MM, Namkoong G (eds) Proceedings of the second international conference on quantitative genetics. Sinauer, Sunderland, MA pp 341-352
33. Jeppesen J, Hein HO, Suadicani P, Gyntelberg F (1998) Triglyceride concentration and ischemic heart disease: an eight-year follow-up in the Copenhagen male study. Circulation 97:1029-1036
34. Khoury MJ, Beaty TH, Cohen BH (eds) (1993) Fundamentals of genetic epidemiology. New York, Oxford University Press
35. Klinger KW, Winqvist R, Riccio A, Andreasen PA, Sartorio R, Nielsen LS, Stuart N, et al (1987) Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis. Proc Natl Acad Sci USA 84:8548-8552
36. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
37. MacCluer JW (1989) Statistical approaches to identifying major locus effects on disease susceptibility. In: Lusis AJ, Sparkes SR (eds) Genetic factors in atherosclerosis: approaches and model systems. Karger, Basel, pp 50-78
38. Mahaney MC, Blangero J, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW (1995) Plasma HDL cholesterol, triglycerides, and adiposity: a quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study. Circulation 92:3240-3248
39. Miller M, Seidler A, Moalemi A, Pearson TA (1998) Normal triglyceride levels and coronary artery disease events: the Baltimore Coronary Observational Long-Term Study (COLTS). J Am Coll Cardiol 31:1252-1257
40. Mitchell BD, Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B, Hixson JE, et al (1996) Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans: the San Antonio Family Heart Study. Circulation 94:2159-2170
41. Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui L-C, et al (1998) Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence. Gene 213:149-157
42. Morton NE (1998) Significance levels in complex inheritance. Am J Hum Genet 62:690-697
43. Mykkänen L, Haffner SM, Rainwater DL, Karhapää P, Miettinen H, Laasko M (1997) Relationship of LDL size to insulin sensitivity in normoglycemic men. Arterioscler Thromb Vasc Biol 17:1447-1453
44. O'Connell P, Leach RJ, Rains D, Taylor T, Garcia D, Ballard L, Holik P, et al (1994) A PCR-based genetic map for human chromosome 3. Genomics 24:557-567
45. Pajukanta P, Nuotio I, Terwilliger JD, Porkka KVK, Ylitalo K, Pihlajamäki J, Suomalainen AJ, et al (1998) Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat Genet 18:369-373
46. Pandya A, Blanton SH, Landa B, Javaheri R, Melvin E, Nance WE, Markello T (1996) Linkage studies in a large kindred with hereditary pancreatitis confirms mapping of the gene to a 16-cM region on 7q. Genomics 38:227-230
47. Rice T, Vogler GP, Laskarzewski PM, Perry TS, Rao DC (1991) Familial aggregation of lipids and lipoproteins in families ascertained through random and nonrandom probands in the Minnesota Lipid Research Clinic Family Study. Hum Biol 63:419-439
48. Rust S, Walter M, Funke H, von Eckardstein A, Cullen P, Kroes HY, Hordijk R, et al (1998) Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategy. Nat Genet 20:96-98
49. Sanghera DK, Aston CE, Saha N, Kamboh MI (1998) DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease. Am J Hum Genet 62:36-44
50. Self SG, Liang K-Y (1987) Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under non-standard conditions. J Am Stat Assoc 82:605-610
51. Singh CF, Boerwinkle E, Moll PP, Templeton AR (1988) Characterization of genes affecting quantitative traits in humans. In: Weir BS, Eisen EJ, Goodman MM, Namkoong G (eds) Proceedings of the second international conference on quantitative genetics. Sinauer, Sunderland, MA, pp 250-269
52. Sparkes RS, Zollman S, Klisak I, Kirchgessner TG, Komaromy MC, Mohandas T, Schotz MC, et al (1987) Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21. Genomics 1:138-144
53. Steiner G, Lewis GF (1996) Hyperinsulinemia and triglyceride-rich lipoproteins. Diabetes 45(Suppl 3):S24-S26
54. Stern MP, Duggirala R, Mitchell BD, Reinhart LJ, Shivakumar S, Shipman PA, Uresandi OC, et al (1996) Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans. Genome Res 6:724-734
55. Stern MP, Haffner SM (1990) Type II diabetes and its complications in Mexican Americans. Diabetes Metab Rev 6: 29-45
56. Stern MP, Rosenthal M, Haffner SM, Hazuda HP, Franco LP (1984) Sex difference in the effects of sociocultural status on diabetes and cardiovascular risk factors in Mexican Americans: the San Antonio Heart Study. Am J Epidemiol 120:834-851
57. Surguchov AP, Page GP, Smith L, Patsch W, Boerwinkle E (1996) Polymorphic markers in apolipoprotein C-III gene flanking regions and hypertriglyceridemia. Arterioscler Thromb Vasc Biol 16:941-947
58. Talmud PJ, Hall S, Holleran S, Ramakrishnan R, Ginsberg HN, Humphries SE (1998) LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics. J Lipid Res 39:1189-1196
59. Whitcomb DC, Preston RA, Aston CE, Sossenheimer MJ, Barua PS, Zhang Y, Wong-Chong A, et al (1996) A gene for hereditary pancreatitis maps to chromosome 7q35. Gastroenterology 110:1975-1980
60. Wittrup HH, Tybjaerg-Hansen A, Nordestgaard BG (1999) Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease: a meta-analysis. Circulation 99:2901-2907
61. Wittrup HH, Tybjaerg-Hansen A, Steffensen R, Deeb SS, Brunzell JD, Jensen G, Nordestgaard BG (1997) A common mutation T(-93)G in the promoter of the lipoprotein lipase gene is associated with elevated plasma triglycerides in both genders and with ischemic heart disease in men: the Copenhagen City Heart Study. Circulation 96 Suppl 8:1-336
62. World Health Organization Expert Committee (1985) Diabetes mellitus: report of a WHO study group. World Health Organization Technical Report Series 727, Geneva, pp 1-113
63. Zeng Q, Dammerman M, Takada Y, Matsunaga A, Breslow JL, Sasaki J (1995) An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population. Hum Genet 95:371-375