Improved aerosolization performance of salbutamol sulfate formulated with lactose crystallized from binary mixtures of ethanol-acetone

Journal of Pharmaceutical Sciences

Volumn 100, Issue 7, 2011, Pages 2665-2684

  Kaialy, Waseem ^a,b   Ticehurst, Martyn D ^c   Murphy, John ^c   Nokhodchi, Ali ^a  

^a MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

^b DAMASCUS UNIVERSITY   (Syrian Arab Republic)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Aerosolization performance; Crystallization; Crystallized lactose; Dry powder inhalers; Particle shape; Particle size; Precipitation; Pulmonary delivery; Salbutamol sulfate; Solid state

Indexed keywords

ACETONE; ALCOHOL; ALPHA LACTOSE; LACTOSE; SALBUTAMOL SULFATE; WATER;

AEROSOL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTALLIZATION; DRUG FORMULATION; DRY POWDER; HUMAN; MORPHOLOGY; NONHUMAN; SOLUTION AND SOLUBILITY;

EID: 79955613972     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22483     Document Type: Article

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