The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient

International Journal of Pharmaceutics

Volumn 392, Issue 1-2, 2010, Pages 178-188

  Kaialy, Waseem ^a   Martin, Gary P ^b   Ticehurst, Martyn D ^c   Momin, Mohammed N ^a   Nokhodchi, Ali ^a,d  

^a MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Crystallisation; Deposition study; Dry powder inhaler; Mannitol; Micromeritic; Ratio of acetone water

Indexed keywords

ACETONE; MANNITOL; SALBUTAMOL SULFATE; WATER;

AEROSOL; ARTICLE; BULK DENSITY; CAPSULE FILLING; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRY POWDER; INFRARED SPECTROSCOPY; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SOLID STATE;

AEROSOLS; ALBUTEROL; BRONCHODILATOR AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DRUG CARRIERS; EXCIPIENTS; MANNITOL; MICROSCOPY, ELECTRON, SCANNING; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POWDERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES;

EID: 77952742519     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.03.057     Document Type: Article

References (30)

1. Bosquillon C., Lombry C., Préat V., Vanbever R. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J. Control. Release 2001, 70:329-339.
2. Burger A., Henck J.O., Hetz S., Rollinger J.M., Weissnicht A.A., Stottner H. Energy/temperature diagram and compression behavior of the polymorphs of d-mannitol. J. Pharm. Sci. 2000, 89:457-468.
3. Byron P.R., Kelly E.L., Kontny M.J., Lovering E.G., Poochikian G.K., Sethi S. Recommendations of the USP advisory panel on aerosols on the USP general chapters on aerosols (601) and uniformity of dosage units (905). Pharm. Forum 1994, 7477-7503.
4. Campbell R.S.N., Williams A.C., Grimsey I.M., Booth S.W. Quantitative analysis of mannitol polymorphs. X-ray powder diffractometry-exploring preferred orientation effects. J. Pharm. Biomed. Anal. 2002, 28:1149-1159.
5. Carr R.L. Evaluating flow properties of solids. Chem. Eng. 1965, 72:163-168.
6. Carr R.L. Classifying flow properties of solids. Chem. Eng. 1965, 72:169-172.
7. Chan H.K., Chew N.Y.K. Novel alternative methods for the delivery of drugs for the treatment of asthma. Adv. Drug Deliv. Rev. 2003, 55:793-805.
8. Dickhoff B.H.J., de Boer A.H., Lambregts D., Frijlink H.W. The interaction between carrier rugosity and carrier payload, and its effect on drug particle redispersion from adhesive mixtures during inhalation. Eur. J. Pharm. Sci. 2005, 59:197-205.
9. Dickhoff B.H.J., de Boer A.H., Lambregts D., Frijlink H.W. The effect of carrier surface and bulk properties on drug particle detachment from crystalline lactose carrier particles during inhalation, as function of carrier payload and mixing time. Eur. J. Pharm. Sci. 2003, 56:291-302.
10. European Commission-Health & Consumer Protection Directorate Provisional Statement on the Safety of Calf-derived Rennet for the Manufacture of Pharmaceutical Grade Lactose 2002.
11. Fults K.A., Miller I.F., Hickey A.J. Effect of particle morphology on emitted dose of fatty acid-treated disodium cromoglycate powder aerosols. Pharm. Dev. Technol. 1997, 2:67-79.
12. Islam N., Stewart P., Larson I., Hartley P. Lactose surface modification by decantation: are drug-fine lactose ratios the key to better dispersion of salmeterol xinafoate from lactose-interactive mixtures?. Pharm. Res. 2004, 21:492-499.
13. Larhrib H., Martin G.P., Marriott C., Prime D. The influence of carrier and drug morphology on drug delivery from dry powder formulations. Int. J. Pharm. 2003, 257:283-296.
14. Louey M.D., Stewart P.J. Particle interactions involved in aerosol dispersion of ternary interactive mixtures. Pharm. Res. 2002, 19:1524-1531.
15. Maa Y.F., Prestrelski S.J. Biopharmaceutical powders particle formation and formulation considerations. Curr. Pharm. Biotechnol. 2000, 1:283-302.
16. Price A.H., Clissold S.P. Salbutamol in the 1980s. A reappraisal of its clinical efficacy. Drugs 1989, 38:77-122.
17. Pritchard J.N. The influence of lung deposition on clinical response. J. Aerosol Med. 2001, 14:19-26.
18. Rabbani N.R., Seville P.C. The influence of formulation components on the aerosolisation properties of spray-dried powders. J. Control. Release 2005, 110:130-140.
19. Rowe R.C., Sheskey P.J., Weller P.J. Handbook of Pharmaceutical Excipients 2003, Pharmaceutical Press, London, UK.
20. Saint-Lorant G., Leterme P., Gayot A., Flament M.P. Influence of carrier on the performance of dry powder inhalers. Int. J. Pharm. 2007, 334:85-91.
21. Smyth H.D.C., Hickey A.J. Carriers in drug powder delivery. Implications for inhalation system design. Am. J. Drug Deliv. 2005, 3:117-132.
22. Srichana T., Martin G.P., Marriott C. Dry powder inhalers: the influence of device resistance and powder formulation on drug and lactose deposition in vitro. Eur. J. Pharm. Sci. 1998, 7:73-80.
23. Steckel H., Bolzen N. Alternative sugars as potential carriers for dry powder inhalations. Int. J. Pharm. 2004, 270:297-306.
24. Tee S.K., Marriott C., Zeng X.M., Martin G.P. The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate. Int. J. Pharm. 2000, 208:111-123.
25. Timsina M.P., Martin G.P., Marriott C., Ganderton D., Yainneskis M. Drug delivery to the respiratory tract using dry powder inhalers. Int. J. Pharm. 1994, 101:1-13.
26. USP Pharmacopeia The Official Compendia of Standards, USP 26/NF 21 2003, United States Pharmacopeial Conventio, Inc, Rockville, MD, Aerosols <601>, pp. 2114-2123.
27. Walter-Levy L. Cristallochimie-sur les variétés cristallines du D-mannitol. C.R. Acad. Sci. Paris Ser. 1968, 267:1779-1782.
28. Yoshinari T., Forbes R.T., York P., Kawashima Y. Moisture induced polymorphic transition of mannitol and its morphological transformation. Int. J. Pharm. 2002, 247:69-77.
29. Zeng X.M., Martin G.P., Marriott C., Pritchard J. Lactose as a carrier in dry powder formulations. The influence of surface characteristics on drug delivery. J. Pharm. Sci. 2001, 90:1424-1434.
30. Zeng X.M., Martin G.P., Tee S.K., Marriott C. The role of fine particle lactose on the dispersion and deaggregation of salbutamol sulphate in an air stream in vitro. Int. J. Pharm. 1998, 176:99-110.