The influence of heating/drying on the crystallisation of amorphous lactose after structural collapse

International Journal of Pharmaceutics

Volumn 158, Issue 2, 1997, Pages 157-164

  Darcy, Patricia ^a   Buckton, Graham ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Amorphous; Collapse; Crystallisation; Differential scanning calorimetry; Drying; Isothermal microcalorimetry; Lactose; Thermogravimetric analysis; Water

Indexed keywords

ALPHA LACTOSE; LACTOSE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; HEATING; MICROCALORIMETRY; PRIORITY JOURNAL; THERMOGRAVIMETRY; WATER LOSS;

EID: 0031451303     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00245-7     Document Type: Article

References (7)

1. Ahlneck C., Zografi G. The molecular basis of moisture effects on the physical and chemical stability of drugs. Int. J. Pharm. 62:1990;87-95.
2. Angberg M. Lactose and thermal analysis with special emphasis on microcalorimetry. Thermochim. Acta. 248:1995;161-176.
3. Briggner L.-E., Buckton G., Bystrom K., Darcy P. The use of isothermal microcalorimetry in the study of changes in crystallinity induced during the processing of powders. Int. J. Pharm. 105:1994;125-135.
4. Buckton G., Darcy P. The use of gravimetric studies to assess the degree of crystallinity of predominantly crystalline powders. Int. J. Pharm. 123:1995;265-271.
5. Buckton G., Darcy P. Water mobility in amorphous lactose below and close to the glass transition temperature. Int. J. Pharm. 136:1996;141-146.
6. Flink, J.M., 1983. Structure and structure transitions in dried carbohydrate materals. In: Peleg, M., Bagley, E.B. (Eds.), Physical Properties of Foods. AVI Publishing, Westport, USA, pp. 473-521.
7. Skrabanja A.T.P., de Meere A.L.J., de Ruiter R.A., van den Oetelaar P.J.M. Lyophilization of biotechnology products. J. Pharm. Sci. Technol. 48:1994;311-317.