Effect of particle morphology on emitted dose of fatty acid-treated disodium cromoglycate powder aerosols

Pharmaceutical Development and Technology

Volumn 2, Issue 1, 1997, Pages 67-79

  Fults, Kristen A ^a   Miller, Irving F ^b,c   Hickey, Anthony J ^a,d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b 1120 Science and Engineering Offices   (United States)

^c The University of Akron   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Aerosol powders; Disodium cromoglycate; Fatty acids; Particle size

Indexed keywords

CROMOGLYCATE DISODIUM;

AEROSOL; ARTICLE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG SOLUBILITY; INHALATIONAL DRUG ADMINISTRATION; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL;

EID: 0031398375     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.3109/10837459709022610     Document Type: Article

References (28)

1. I. Gonda, A semi-empirical model of aerosol deposition in the human respiratory tract for mouth inhalation, J. Pharm. Pharmacol., 33(11):692-696 (1981).
2. W. Stahlhofen, J. Gebhart, J. Heyder, and G. Scheuch, Deposition pattern of droplets from medical nebulizers in the human respiratory tract, Bull. Eur. Physiopathol., 19(5):459-463 (1983).
3. S. H. Curry, A. J. Taylor, S. Evans, S. Godfrey, and E. Zeidifard, Disposition of disodium cromoglycate administered in three particle sizes, J. Pharm. Pharmacol., 26S:79P-80P (1974).
4. M. Lippman and V. Timbrell, Particle loading in the human lung - human experience and implications for exposure limits, J. Aer. Med., 38:155-168 (1990).
5. K. Fults, R. S. Pillai, I. F. Miller, and A. J. Hickey, Preparation and aerodynamic behavior of elongated particles of disodium cromoglycate, Pharm. Res., 10:S86 (1991).
6. A. J. Hickey, K. Fults, and R. S. Pillai, Use of particle morphology to influence the delivery of drugs from dry powder aerosols, J. Biopharm. Sci., 3:107-113 (1992).
7. A. J. Hickey, N. M. Concessio, M. M. VanOort, and R. M. Platz, Factors influencing the dispersion of dry powders as aerosols, Pharm. Tech., 18(8):58-64 (1994).
8. N. M. Concessio and A. J. Hickey, Assessments of micronized powders dispersed as aerosols. Pharm. Tech. 18(9):88-98 (1994).
9. J. Visser, An invited review: Van der Waals and other cohesive forces affecting powder fluidization, Powder Tech., 58:1-10 (1989).
10. A. J. Hickey, G. V. Jackson, and F. J. T. Fildes, Preparation and characteristics of disodium fluorescein powders in association with lauric and capric acids, J. Pharm. Sci., 77(9):804-809 (1988).
11. A. Darbre, Esterification, in K. Blau and G. King (eds.), Handbook of Derivatives for Chromatography, Heyden and Son, Ltd., London, 1978, pp. 39-103.
12. V. G. Berezkin, Chemical Methods in Gas Chromatography, Elsevier, New York, 1983, pp. 1-66.
13. E. P. Bertin, Principles and Practice of X-Ray Spectrometric Analysis, Plenum Press, New York, 1975, pp. 435-457.
14. J. A. Chandler, X-ray microanalysis in the electron microscope, In A.M. Glauert (ed.), Practical Methods in Electron Microscopy, N. Holland Publishing Co., Amsterdam, 1976, p. 319.
15. J. B. Bates, Infrared emission spectroscopy, in J. R. Ferraro and L. Basile (eds.), Fourier Transform Infrared Spectroscopy: Applications to Chemical Systems, Academic Press, New York, 1978, pp. 99-142.
16. A. D. Cross, and R. A. Jones, An Introduction to Practical Infra-red Spectroscopy, 3rd ed., Butterworths, London, 1969.
17. Y. Tian, D. Parasrampuria, M. Kanke, and A. J. Hickey, Manufacture and in-vitro assessment of bromsulphthalein and phenolphthalein loaded polyester microspheres, Drug Dev. Ind. Pharm., 20(7):1159-1178 (1994).
18. K. Diem, Scientific Tables, 6th ed., Geigy Pharmaceuticals, Ardsley, UK, 1968, p. 281.
19. J. S. G. Cox, G. D. Woodard, and W. C. McCrone. Solid-state chemistry of cromolyn sodium (disodium cromoglycate), J. Pharm. Sci., 60(10):1458-1465 (1971).
20. B. Liu, K. Whitby, and H. Liu, Electrostatic aerosol sampler for light and electron microscopy, Rev. of Sci. Instr., 38(1):100-102 (1967).
21. W. Daniel. Biostatistics: A Foundation for Analysis in the Health Sciences, John Wiley & Sons, Inc., New York, 1987, pp. 135-145.
22. A.J. Hickey, The effect of hydrophobic coatings upon the behavior of pharmaceutical aerosol powders, in Aerosols: Science, Industry, Health and Environment, Pergamon Press, Oxford, 1990, pp. 1315-1318.
23. A. H. L. Chow, P. K. K. Chow, W. Zhongshan, and D. J. W. Grant, Modification of acetaminophen crystals: Influence of growth in aqueous solutions containing p. acetoxyacetanilide on crystal properties, Int. J. Pharm., 24:239-258 (1985).
24. K. Y. Chow, J. Go, W. Zhongshan, M. Mehdizadeh, and D.J.W. Grant, Modification of adipic acid crystals. II. Influence of growth in the presence of oleic acid on crystal properties, Int. J. Pharm., 25:41-55 (1985).
25. J. W. Mullin, Crystallization, 3rd ed., Butterworth-Heinemann, Boston, 1993, pp. 24-27.
26. P. Paronen, A. Poso, M. Vidgren, J. Gynther, and P. York, Physical structure and dehydration of disodium cromoglycate, Pharm. Res., 10(10):S-162 (1993).
27. A. J. Hickey, T. B. Martonen, and Y. Yang, Theoretical relationship of lung deposition to the fine particle fraction of inhalation aerosols, Pharm. Acta. Helv. 71:185-190 (1996).
28. T. B. Martonen, I. Katz, K. Fults, and A. J. Hickey, Use of analytically defined estimates of aerosol respirable fraction to predict lung deposition patterns, Pharm. Res., 9:1634-1639 (1992).