Modulation of α-synuclein aggregation by dopamine in the presence of MPTP and its metabolite

FEBS Journal

Volumn 278, Issue 10, 2011, Pages 1688-1698

  Jethva, Prashant N ^a   Kardani, Jay R ^a   Roy, Ipsita ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

amyloid; fibrillation; Parkinson's disease; synuclein; thioflavin T

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; DOPAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); THIOFLAVINE;

ARTICLE; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE; TOXICOKINETICS;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ALPHA-SYNUCLEIN; DOPAMINE; HUMANS; PROTEIN STRUCTURE, QUATERNARY;

EID: 79955609986     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08093.x     Document Type: Article

References (40)

1. Pastor MT, Kümmerer N, Schubert V, Esteras-Chopo A, Dotti CG, de la Paz ML, &, Serrano L, (2008) Amyloid toxicity is independent of polypeptide sequence, length and chirality. J Mol Biol 375, 695-707. (Pubitemid 350297277)
2. Stefani M, (2010) Structural polymorphism of amyloid oligomers and fibrils underlies different fibrillization pathways, immunogenicity and cytotoxicity. Curr Protein Pept Sci 11, 343-354.
3. Uversky VN, Li J, &, Fink AL, (2001) Pesticides directly accelerate the rate of α-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett 500, 105-108. (Pubitemid 32607541)
4. Di Monte DA, (2003) The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol 2, 531-538. (Pubitemid 36994992)
5. Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, et al. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302, 841. (Pubitemid 37339619)
6. Langston JW, Ballard P, Tetrud JW, &, Irwin I, (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980. (Pubitemid 13189531)
7. +): identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci Lett 48, 87-92. (Pubitemid 14084283)
8. Philippens IH, 't Hart BA, &, Torres G, (2010) The MPTP marmoset model of Parkinsonism: a multi-purpose non-human primate model for neurodegenerative diseases. Drug Discov Today 15, 985-990.
9. Di Monte DA, Lavasani M, &, Manning-Bog AB, (2002) Environmental factors in Parkinson's disease. Neurotoxicology 23, 487-502. (Pubitemid 36527669)
10. Forno LS, Langston JW, DeLanney LE, Irwin I, &, Ricaurte GA, (1986) Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 20, 449-455. (Pubitemid 16005662)
11. Kowall NW, Hantraye P, Brouillet E, Beal MF, McKee AC, &, Ferrante RJ, (2000) MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. Neuroreport 11, 211-213. (Pubitemid 30053420)
12. Schulz JB, (2007) Mechanisms of neurodegeneration in idiopathic Parkinson's disease. Parkinsonism Relat Disord Suppl 3, S306-S308. (Pubitemid 351215259)
13. +, or paraquat. Proc Natl Acad Sci USA 105, 15136-15141.
14. Leong SL, Cappai R, Barnham KJ, &, Pham CL, (2009) Modulation of alpha-synuclein aggregation by dopamine: a review. Neurochem Res 34, 1836-1846.
15. Clayton DF, &, George JM, (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J Neurosci Res 58, 120-129. (Pubitemid 29463698)
16. Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, Trojanowski JQ, Lee VM, &, Ischiropoulos H, (2001) Induction of alpha-synuclein aggregation by intracellular nitrative insult. J Neurosci 21, 8053-8061. (Pubitemid 32952762)
17. Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, &, Lee VM, (2005) Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J Biol Chem 280, 21212-21219. (Pubitemid 40805683)
18. Cappai R, Leck SL, Tew DJ, Williamson NA, Smith DP, Galatis D, Sharples RA, Curtain CC, Ali FE, Cherny RA, et al. (2005) Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway. FASEB J 19, 1377-1379. (Pubitemid 41113755)
19. Wood SJ, Wypych J, Steavenson S, Louis JC, Citron M, &, Biere AL, (1999) α-Synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J Biol Chem 274, 19509-19512.
20. Vassar PS, &, Culling CF, (1959) Fluorescent stains, with special reference to amyloid and connective tissues. Arch Pathol 68, 487.
21. Uversky VN, Li J, &, Fink AL, (2001) Evidence for a partially folded intermediate in α-synuclein fibril formation. J Biol Chem 276, 10737-10744. (Pubitemid 38089246)
22. Bae SY, Kim S, Hwang H, Kim HK, Yoon HC, Kim JH, Lee S, &, Kim TD, (2010) Amyloid formation and disaggregation of α-synuclein and its tandem repeat (α-TR). Biochem Biophys Res Commun 400, 531-536.
23. 3+ on amyloid-β stability, oligomerization, and aggregation: amyloid-{beta} destabilization promotes annular protofibril formation. J Biol Chem doi:.
24. Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, et al. (2008) RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells. J Biol Chem 283, 6489-6500.
25. Uversky VN, Li J, Bower K, &, Fink AL, (2002) Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease. Neurotoxicology 23, 527-536. (Pubitemid 36527673)
26. Heikkila RE, Hess A, &, Duvoisin RC, (1984) Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 224, 1451-1453. (Pubitemid 14123348)
27. Fornai F, Schlüter OM, Lenzi P, Gesi M, Ruffoli R, Ferrucci M, Lazzeri G, Busceti CL, Pontarelli F, Battaglia G, et al. (2005) Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and α-synuclein. Proc Natl Acad Sci USA 102, 3413-3418. (Pubitemid 40328059)
28. Miele M, Esposito G, Migheli R, Sircana S, Zangani D, Fresu GL, &, Desole MS, (1995) Effects of allopurinol on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced neurochemical changes in the striatum and in the brainstem of the rat. Neurosci Lett 183, 155-159.
29. Pronchik J, He X, Giurleo JT, &, Talaga DS, (2010) In vitro formation of amyloid from alpha-synuclein is dominated by reactions at hydrophobic interfaces. J Am Chem Soc 132, 9797-9803.
30. Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, et al. (2002) Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci USA 99, 14524-14529. (Pubitemid 35257704)
31. Heikkila RE, Manzino L, Cabbat FS, &, Duvoisin R, (1984) Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine by monoamine oxidase inhibitors. Nature 311, 467-469. (Pubitemid 14035453)
32. Dauer W, &, Przedborski S, (2003) Parkinson's disease: mechanisms and models. Neuron 39, 889-909. (Pubitemid 37130207)
33. Mejías R, Villadiego J, Pintado CO, Vime PJ, Gao L, Toledo-Aral JJ, Echevarría M, &, Lõpez-Barneo J, (2006) Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice. J Neurosci 26, 4500-4508. (Pubitemid 44315349)
34. Romero-Ruiz A, Mejías R, Díaz-Martín J, Lõpez-Barneo J, &, Gao L, (2010) Mesencephalic and striatal protein profiles in mice over-expressing glucose-6-phosphate dehydrogenase in dopaminergic neurons. J Proteomics 73, 1747-1757.
35. Yang L, Calingasan NY, Wille EJ, Cormier K, Smith K, Ferrante RJ, &, Beal MF, (2009) Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. J Neurochem 109, 1427-1439.
36. Chau KY, Cooper JM, &, Schapira AH, (2010) Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells. Neurochem Int 57, 525-529.
37. Sambrook J, &, Russell D, (2001) Molecular Cloning: A Laboratory Manual. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, New York, 1:1.31-1.38.
38. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, &, Klenk DC, (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150, 76-85. (Pubitemid 16258399)
39. Laemmli UK, (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
40. Switzer RC III, Merril CR, &, Shifrin S, (1979) A highly sensitive silver stain for detecting proteins and peptides in polyacrylamide gels. Anal Biochem 98, 231-237. (Pubitemid 10235500)