Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer disease

Free Radical Biology and Medicine

Volumn 50, Issue 11, 2011, Pages 1526-1535

  Seo, Ji Seon ^a   Lee, Kang Woo ^a   Kim, Tae Kyung ^a   Baek, In Sun ^a   Im, Joo Young ^a   Han, Pyung Lim ^a  

^a Ewha Womans University   (South Korea)

Author keywords

ABAD; Free radicals; Glucocorticoid; Mitochondria; Plaque pathogenesis; ROS; Stress

Indexed keywords

5 CHLORO 4 [N (CYCLOPROPYLMETHYL) N PROPYLAMINO] 2 METHYL 6 (2,4,6 TRICHLOROANILINO)PYRIMIDINE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CITRATE SYNTHASE; CORTICOSTERONE; CYTOCHROME C OXIDASE; MALONALDEHYDE; MIFEPRISTONE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; SUCCINATE DEHYDROGENASE (UBIQUINONE); TESTOSTERONE 17BETA DEHYDROGENASE; UBIQUINOL CYTOCHROME C REDUCTASE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIORAL STRESS; CELL CULTURE; CELL STRAIN; CELL STRAIN SH SY5Y; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOSE RESPONSE; ENZYME ACTIVITY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARIETAL CORTEX; PATHOGENESIS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRIFORM CORTEX; RESPIRATORY CHAIN; RNA INTERFERENCE; TRANSGENIC MOUSE;

17-HYDROXYSTEROID DEHYDROGENASES; ALZHEIMER DISEASE; ANIMALS; BRAIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MITOCHONDRIA; MUTATION; OXIDATIVE STRESS; PRESENILIN-1; RESTRAINT, PHYSICAL; SERUM AMYLOID A PROTEIN; STRESS, PSYCHOLOGICAL; UP-REGULATION;

MURINAE; MUS;

EID: 79955598830     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.02.035     Document Type: Article

References (58)

1. D.J. Selkoe, and D. Schenk Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics Annu. Rev. Pharmacol. Toxicol. 43 2003 545 584 (Pubitemid 37372653)
2. C.M. Filley, Y.D. Rollins, C.A. Anderson, D.B. Arciniegas, K.L. Howard, J.R. Murrell, P.J. Boyer, B.K. Kleinschmidt-DeMasters, and B. Ghetti The genetics of very early onset Alzheimer disease Cognit. Behav. Neurol. 20 2007 149 156 (Pubitemid 350195181)
3. K.R. Bales, J.C. Dodart, R.B. DeMattos, D.M. Holtzman, and S.M. Paul Apolipoprotein E, amyloid, and Alzheimer disease Mol. Interv. 2 2002 363 375
4. L. Bertram, and R.E. Tanzi Genome-wide association studies in Alzheimer's disease Hum. Mol. Genet. 18 2009 R137 R145
5. D. Harman Alzheimer's disease pathogenesis: role of aging Ann. N. Y. Acad. Sci. 1067 2006 454 460 (Pubitemid 43806358)
6. N. Pomara, W.M. Greenberg, M.D. Branford, and P.M. Doraiswamy Therapeutic implications of HPA axis abnormalities in Alzheimer's disease: review and update Psychopharmacol. Bull. 37 2003 120 134
7. J.G. Csernansky, H. Dong, A.M. Fagan, L. Wang, C. Xiong, D.M. Holtzman, and J.C. Morris Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia Am. J. Psychiatry 163 2006 2164 2169 (Pubitemid 46114238)
8. K.W. Lee, J.B. Kim, J.S. Seo, T.K. Kim, J.Y. Im, I.S. Baek, K.S. Kim, J.K. Lee, and P.L. Han Behavioral stress enhances Alzheimer's disease pathogenesis via metabolic oxidative stress J. Neurochem. 108 2009 165 175
9. J.E. Kang, J.R. Cirrito, H. Dong, J.G. Csernansky, and D.M. Holtzman Acute stress increases interstitial fluid amyloid-beta via corticotropin- releasing factor and neuronal activity Proc. Natl. Acad. Sci. U. S. A. 104 2007 10673 10678 (Pubitemid 47185723)
10. S. Kunimoto, S. Nakamura, K. Wada, and T. Inoue Chronic stress-mutated presenilin 1 gene interaction perturbs neurogenesis and accelerates neurodegeneration Exp. Neurol. 221 2010 175 185
11. S.M. Rothman, and M.P. Mattson Adverse stress, hippocampal networks, and Alzheimer's disease NeuroMol. Med. 12 2010 56 70
12. M.T. Lin, and M.F. Beal Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 443 2006 787 795 (Pubitemid 44622683)
13. X. Chen, D. Stern, and S.D. Yan Mitochondrial dysfunction and Alzheimer's disease Curr. Alzheimer Res. 3 2006 515 520 (Pubitemid 46066427)
14. J.W. Lustbader, M. Cirilli, C. Lin, H.W. Xu, K. Takuma, N. Wang, C. Caspersen, X. Chen, S. Pollak, M. Chaney, F. Trinchese, S. Liu, F. Gunn-Moore, L.F. Lue, D.G. Walker, P. Kuppusamy, Z.L. Zewier, O. Arancio, D. Stern, S.S. Yan, and H. Wu ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease Science 304 2004 448 452 (Pubitemid 38495942)
15. J.X. Chen, and S.S. Yan Amyloid-beta-induced mitochondrial dysfunction J. Alzheimers Dis. 12 2007 177 184
16. A.T. Marques, P.A. Fernandes, and M.J. Ramos ABAD: a potential therapeutic target for Abeta-induced mitochondrial dysfunction in Alzheimer's disease Mini Rev. Med. Chem. 9 2009 1002 1008
17. K. Takuma, J. Yao, J. Huang, H. Xu, X. Chen, J. Luddy, A.C. Trillat, D.M. Stern, O. Arancio, and S.S. Yan ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction FASEB J. 19 2005 597 598 (Pubitemid 40471256)
18. J. Yao, R.W. Irwin, L. Zhao, J. Nilsen, R.T. Hamilton, and R.D. Brinton Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 106 2009 14670 14675
19. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, and G. Cole Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102 (Pubitemid 26332733)
20. J.L. Jankowsky, H.H. Slunt, T. Ratovitski, N.A. Jenkins, N.G. Copeland, and D.R. Borchelt Co-expression of multiple transgenes in mouse CNS: a comparison of strategies Biomol. Eng. 17 2001 157 165 (Pubitemid 32409891)
21. K.S. Kim, and P.L. Han Optimization of chronic stress paradigms using anxiety- and depression-like behavioral parameters J. Neurosci. Res. 83 2006 497 507
22. J.Y. Im, D. Kim, S.G. Paik, and P.L. Han Cyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation Free Radic. Biol. Med. 41 2006 960 972 (Pubitemid 44247547)
23. J.S. Seo, T.K. Kim, Y.H. Leem, K.W. Lee, S.K. Park, I.S. Baek, K.S. Kim, G.J. Im, S.M. Lee, Y.H. Park, and P.L. Han SK-PC-B70M confers anti-oxidant activity and reduces Abeta levels in the brain of Tg2576 mice Brain Res. 1261 2009 100 108
24. J.S. Seo, J.H. Yun, I.S. Baek, Y.H. Leem, H.W. Kang, H.K. Cho, Y.S. Lyu, H.J. Son, and P.L. Han Oriental medicine Jangwonhwan reduces Abeta(1-42) level and beta-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease J. Ethnopharmacol. 128 2010 206 212
25. J.Y. Im, and P.L. Han Nordihydroguaiaretic acid induces astroglial death via glutathione depletion J. Neurosci. Res. 85 2007 3127 3134
26. S.T. Smiley, M. Reers, C. Mottola-Hartshorn, M. Lin, A. Chen, T.W. Smith, G.D. Steele Jr., and L.B. Chen Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1 Proc. Natl. Acad. Sci. U. S. A. 88 1991 3671 3675 (Pubitemid 21916685)
27. J.S. Seo, Y.H. Leem, K.W. Lee, S.W. Kim, J.K. Lee, and P.L. Han Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease J. Alzheimers Dis. 21 2010 263 276
28. H. Dong, B. Goico, M. Martin, C.A. Csernansky, A. Bertchume, and J.G. Csernansky Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress Neuroscience 127 2004 601 609 (Pubitemid 38993164)
29. H. Dong, C.M. Yuede, H.S. Yoo, M.V. Martin, C. Deal, A.G. Mace, and J.G. Csernansky Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice Neuroscience 31 2008 154 163
30. Y.H. Jeong, C.H. Park, J. Yoo, K.Y. Shin, S.M. Ahn, H.S. Kim, S.H. Lee, P.C. Emson, and Y.H. Suh Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model FASEB J. 20 2006 729 731 (Pubitemid 46671196)
31. R.E. Tanzi, and L. Bertram Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective Cell 120 2005 545 555 (Pubitemid 40269768)
32. O. Berton, C.A. McClung, R.J. Dileone, V. Krishnan, W. Renthal, S.J. Russo, D. Graham, N.M. Tsankova, C.A. Bolanos, M. Rios, L.M. Monteggia, D.W. Self, and E.J. Nestler Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress Science 311 2006 864 868 (Pubitemid 43228853)
33. V.W. Henderson Estrogen, cognition, and a woman's risk of Alzheimer's disease Am. J. Med. 103 1997 11S 18S (Pubitemid 27444160)
34. M.J. Callahan, W.J. Lipinski, F. Bian, R.A. Durham, A. Pack, and L.C. Walker Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice Am. J. Pathol. 158 2001 1173 1177 (Pubitemid 32221809)
35. R.S. Turner Alzheimer's disease in man and transgenic mice: females at higher risk Am. J. Pathol. 158 2001 797 801 (Pubitemid 32221772)
36. J. Wang, H. Tanila, J. Puoliväli, I. Kadish, and T. van Groen Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice Neurobiol. Dis. 14 2003 318 327 (Pubitemid 37543511)
37. V.K. Patchev, and O.F.X. Almeida Gender specificity in the neural regulation of the response to stress: new leads from classical paradigms Mol. Neurobiol. 16 1998 63 77 (Pubitemid 28372725)
38. I. Sotiropoulos, J.J. Cerqueira, C. Catania, A. Takashima, N. Sousa, and O.F. Almeida Stress and glucocorticoid footprints in the brain-the path from depression to Alzheimer's disease Neurosci. Biobehav. Rev. 32 2008 1161 1173
39. D.A. Butterfield Amyloid beta-peptide(1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain Free Radic. Res. 36 2002 1307 1313 (Pubitemid 35469517)
40. J.L. Madrigal, R. Olivenza, M.A. Moro, I. Lizasoain, P. Lorenzo, J. Rodrigo, and J.C. Leza Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain Neuropsychopharmacology 24 2001 420 429 (Pubitemid 32157558)
41. J.L. Madrigal, M.A. Moro, I. Lizasoain, P. Lorenzo, A.P. Fernández, J. Rodrigo, L. Boscá, and J.C. Leza Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain Neuropsychopharmacology 28 2003 1579 1588 (Pubitemid 41070858)
42. K.B. Beckman, and B.N. Ames The free radical theory of aging matures Physiol. Rev. 78 1998 547 581 (Pubitemid 28182903)
43. T. Finkel, and N.J. Holbrook Oxidants, oxidative stress and the biology of ageing Nature 408 2000 239 247
44. S. Leutner, A. Eckert, and W.E. Müller ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain J. Neural Transm. 108 2001 955 967 (Pubitemid 32802093)
45. V. Chauhan, and A. Chauhan Oxidative stress in Alzheimer's disease Pathophysiology 13 2006 195 208
46. I.G. Onyango, and S.M. Khan Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease Curr. Alzheimer Res. 3 2006 339 349 (Pubitemid 44351477)
47. X. Zhu, B. Su, X. Wang, M.A. Smith, and G. Perry Causes of oxidative stress in Alzheimer disease Cell. Mol. Life Sci. 64 2007 2202 2210 (Pubitemid 47347959)
48. W.E. Müller, A. Eckert, C. Kurz, G.P. Eckert, and K. Leuner Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease-therapeutic aspects Mol. Neurobiol. 41 2010 159 171
49. R. Sultana, and D.A. Butterfield Role of oxidative stress in the progression of Alzheimer's disease J. Alzheimers Dis. 19 2010 341 353
50. Y. Christen Oxidative stress and Alzheimer disease Am. J. Clin. Nutr. 71 2000 621S 629S (Pubitemid 30061247)
51. N.G. Bazan, R. Palacios-Pelaez, and W.J. Lukiw Hypoxia signaling to genes: significance in Alzheimer's disease Mol. Neurobiol. 26 2002 283 298 (Pubitemid 35239805)
52. Pratico, D. Causes and consequences of oxidative stress in neurodegenerative diseases. In Genotype-Proteotype-Phenotype Relationships in Neurodegenerative Diseases (Cummings et al., Eds.). Berlin: Springer-Verlag; 2005:37-44.
53. A. Gella, and N. Durany Oxidative stress in Alzheimer disease Cell Adhes. Migrat. 3 2009 88 93
54. A.E. Roher, T.C. Kasunic, A.S. Woods, R.J. Cotter, M.J. Ball, and R. Fridman Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A Biochem. Biophys. Res. Commun. 205 1994 1755 1761
55. R.N. LePage, A.J. Fosang, S.J. Fuller, G. Murphy, G. Evin, K. Beyreuther, C.L. Masters, and D.H. Small Gelatinase A possesses a β-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease FEBS Lett. 377 1995 267 270
56. S.D. Yan, and D.M. Stern Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD) Int. J. Exp. Pathol. 86 2005 161 171 (Pubitemid 40813912)
57. J.X. Chen, and S.S. Yan Role of mitochondrial amyloid-beta in Alzheimer's disease J. Alzheimers Dis. 20 S2 2010 S569 S578
58. J. Du, Y. Wang, R. Hunter, Y. Wei, R. Blumenthal, C. Falke, R. Khairova, R. Zhou, P. Yuan, R. Machado-Vieira, B.S. McEwen, and H.K. Manji Dynamic regulation of mitochondrial function by glucocorticoids Proc. Natl. Acad. Sci. U. S. A. 106 2009 3543 3548