Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice

Free Radical Biology and Medicine

Volumn 50, Issue 11, 2011, Pages 1503-1516

  Tsai, Pei Yi ^a   Ka, Shuk Man ^b   Chao, Tai Kuang ^b   Chang, Jia Ming ^c   Lin, Shih Hua ^b   Li, Chen Yun ^b   Kuo, Mao Tien ^d   Chen, Peini ^d   Chen, Ann ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

^d GOLDEN BIOTECHNOLOGY CORPORATION   (Taiwan)

Author keywords

Antrodia camphorata; Antroquinonol; Epithelial hyperplasia lesion; Free radicals; Glomerular sclerosis; Nuclear factor E2 related factor 2; Nuclear factor B; Oxidative stress; Podocyte injury; Transforming growth factor 1

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ANTROQUINONOL; CD3 ANTIGEN; CELL MARKER; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CREATININE; DESMIN; DOXORUBICIN; FUNGAL EXTRACT; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTRODIA CAMPHORATA; ARTICLE; CELL DAMAGE; CELL INFILTRATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG MECHANISM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM HYPERPLASIA; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLOMERULOPATHY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY DYSFUNCTION; KIDNEY FIBROSIS; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN URINE LEVEL; PROTEINURIA; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TAIWAN; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; ANTRODIA; DISEASE MODELS, ANIMAL; FEMALE; FOCAL EPITHELIAL HYPERPLASIA; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; INFLAMMATION; KIDNEY; MICE; MICE, INBRED BALB C; NF-E2-RELATED FACTOR 2; NF-KAPPA B; OXIDATIVE STRESS; SCLEROSIS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; UBIQUINONE;

BASIDIOMYCOTA; CINNAMOMUM CAMPHORA; MUS; TAIWANOFUNGUS CAMPHORATUS;

EID: 79955575759     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.02.029     Document Type: Article

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