Multi-scaled explorations of binding-induced folding of intrinsically disordered protein inhibitor IA3 to its target enzyme

PLoS Computational Biology

Volumn 7, Issue 4, 2011, Pages

  Wang, Jin ^a,b,c   Wang, Yong ^a   Chu, Xiakun ^b   Hagen, Stephen J ^d   Han, Wei ^b   Wang, Erkang ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b JILIN UNIVERSITY   (China)

^c STONY BROOK UNIVERSITY   (United States)

^d University of Florida ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; FREE ENERGY; MOLECULAR DYNAMICS; STOCHASTIC SYSTEMS;

ASPARTIC PROTEINASE; BIO-MOLECULAR; BIOMOLECULAR RECOGNITION; CONFORMATIONAL CHANGE; FOLDINGS; INTRINSICALLY DISORDERED PROTEINS; NON-NATIVE INTERACTIONS; PROTEIN FOLDINGS; PROTEIN INHIBITORS; RECOGNITION PROCESS;

ENZYMES;

ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; PROTEIN IA3; UNCLASSIFIED DRUG; PAI3 PROTEIN, S CEREVISIAE; PEPSIN A; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PROCESS DEVELOPMENT; PROCESS MODEL; PROTEIN DEFECT; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; STOCHASTIC MODEL; STRUCTURE ANALYSIS; ALGORITHM; BIOLOGY; CHEMISTRY; COMPUTER SIMULATION; KINETICS; METABOLISM; METHODOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; STATISTICS; SURFACE PROPERTY; TEMPERATURE; THERMODYNAMICS;

ALGORITHMS; ASPARTIC ACID PROTEASES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; KINETICS; PEPSIN A; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STOCHASTIC PROCESSES; SURFACE PROPERTIES; TEMPERATURE; THERMODYNAMICS;

EID: 79955570145     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001118     Document Type: Article

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