Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 29, 2008, Pages 9999-10004

  Zarrine Afsar, Arash ^a   Wallin, Stefan ^a,d   Neculai, A Mirela ^a,c   Neudecker, Philipp ^a,b   Howell, P Lynne ^a,c   Davidson, Alan R ^a   Hue, Sun Chan ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d HARVARD UNIVERSITY   (United States)

Author keywords

Double mutant cycles; Fyn SH3 domain; G models; HP model; Langevin dynamics

Indexed keywords

PROTEIN SH3;

ARTICLE; ENERGY TRANSFER; HYDROPHOBICITY; KINETICS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; THERMODYNAMICS;

AMINO ACID SUBSTITUTION; BIOPHYSICS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HYDROPHOBICITY; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTO-ONCOGENE PROTEINS C-FYN; SRC HOMOLOGY DOMAINS; THERMODYNAMICS;

EID: 48249138078     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801874105     Document Type: Article

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