Efficient induction of CD25- iTreg by co-immunization requires strongly antigenic epitopes for T cells

BMC Immunology

Volumn 12, Issue , 2011, Pages

  Geng, Shuang ^a   Yu, Yang ^a   Kang, Youmin ^a   Pavlakis, George ^b   Jin, Huali ^a,c   Li, Jinyao ^a,b   Hu, Yanxin ^a   Hu, Weibin ^a   Wang, Shuang ^a   Wang, Bin ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; BLOCKING ANTIBODY; CYTOKINE; DNA VACCINE; HLA ANTIGEN CLASS 2; INSECT PROTEIN; LEUKOCYTE ANTIGEN; SALIVA PROTEIN;

ALLERGENICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ANTIGENIC MODULATION; ANTIGENICITY; ARTICLE; CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FLEA; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; SKIN ALLERGY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ADOPTIVE TRANSFER; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CONTACT DERMATITIS; DRUG EFFECT; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ANTIBODIES, BLOCKING; ANTIGENS, CD; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; DERMATITIS, CONTACT; EPITOPES, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INSECT PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; SALIVARY PROTEINS AND PEPTIDES; SIPHONAPTERA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; VACCINES, DNA;

EID: 79955564011     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-12-27     Document Type: Article

References (27)

1. Aiello S, Cassis P, Cassis L, Tomasoni S, Benigni A, Pezzotta A, Cavinato RA, Cugini D, Azzollini N, Mister M, et al. DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties. Transplantation 2007, 83:474-84. 10.1097/01.tp.0000251808.91901.c3, 17318081.
2. Glisic S, Ehlenbach S, Jailwala P, Waukau J, Jana S, Ghosh S. Inducible regulatory T cells (iTregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls. Cell Tissue Res 339:585-95.
3. Horwitz DA, Zheng SG, Gray JD. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol 2008, 29:429-35. 10.1016/j.it.2008.06.005, 18676178.
4. Jin H, Kang Y, Zheng G, Xie Q, Xiao C, Zhang X, Yu Y, Zhu K, Zhao G, Zhang F, et al. Induction of active immune suppression by co-immunization with DNA- and protein-based vaccines. Virology 2005, 337:183-91. 10.1016/j.virol.2005.03.029, 15914231.
5. Zhang W, Jin H, Hu Y, Yu Y, Li X, Ding Z, Kang Y, Wang B. Protective response against type 1 diabetes in nonobese diabetic mice after coimmunization with insulin and DNA encoding proinsulin. Hum Gene Ther 21:171-8.
6. Kang Y, Jin H, Zheng G, Du X, Xiao C, Zhang X, Geng S, Li X, Wang J, Chen A, et al. Co-inoculation of DNA and protein vaccines induces antigen-specific T cell suppression. Biochem Biophys Res Commun 2007, 353:1034-9. 10.1016/j.bbrc.2006.12.124, 17204242.
7. Jin H, Xiao C, Geng S, Hu Y, She R, Yu Y, Kang Y, Wang B. Protein/DNA vaccine-induced antigen-specific Treg confer protection against asthma. Eur J Immunol 2008, 38:2451-63. 10.1002/eji.200737899, 18792401.
8. Lam A, Yu A. Applied dermatology: overview of flea allergy dermatitis. Compend Contin Educ Vet 2009, 31:220-5.
9. Rust MK, Dryden MW. The biology, ecology, and management of the cat flea. Annu Rev Entomol 1997, 42:451-73. 10.1146/annurev.ento.42.1.451, 9017899.
10. Andre S, Tough DF, Lacroix-Desmazes S, Kaveri SV, Bayry J. Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. Am J Pathol 2009, 174:1575-87. 10.2353/ajpath.2009.080987, 2671245, 19349365.
11. Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006, 108:253-61. 10.1182/blood-2005-11-4567, 1895836, 16537805.
12. Shevach EM, Stephens GL. The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?. Nat Rev Immunol 2006, 6:613-8. 10.1038/nri1867, 16868552.
13. Shevach EM, DiPaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM. The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev 2006, 212:60-73. 10.1111/j.0105-2896.2006.00415.x, 16903906.
14. Shevach EM. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006, 25:195-201. 10.1016/j.immuni.2006.08.003, 16920638.
15. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-87. 10.1016/j.cell.2008.05.009, 18510923.
16. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997, 389:737-42. 10.1038/39614, 9338786.
17. Klareskog L, Catrina AI, Paget S. Rheumatoid arthritis. Lancet 2009, 373:659-72. 10.1016/S0140-6736(09)60008-8, 19157532.
18. Sakaguchi S, Toda M, Asano M, Itoh M, Morse SS, Sakaguchi N. T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases. J Autoimmun 1996, 9:211-20. 10.1006/jaut.1996.0026, 8738965.
19. Quartier P, Brethon B, Philippet P, Landman-Parker J, Le Deist F, Fischer A. Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet 2001, 358:1511-3. 10.1016/S0140-6736(01)06573-4, 11705566.
20. Traynor AE, Schroeder J, Rosa RM, Cheng D, Stefka J, Mujais S, Baker S, Burt RK. Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study. Lancet 2000, 356:701-7. 10.1016/S0140-6736(00)02627-1, 11085688.
21. Wahl SM, Swisher J, McCartney-Francis N, Chen W. TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells. J Leukoc Biol 2004, 76:15-24. 10.1189/jlb.1103539, 14966194.
22. Yoshimura A, Wakabayashi Y, Mori T. Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem 147:781-92.
23. Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martinez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009, 10:1000-7. 10.1038/ni.1774, 2729804, 19633673.
24. Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, Benoist C, Rudensky AY. Stability of the regulatory T cell lineage in vivo. Science 329:1667-71.
25. Deng L, Langley RJ, Brown PH, Xu G, Teng L, Wang Q, Gonzales MI, Callender GG, Nishimura MI, Topalian SL, et al. Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor. Nat Immunol 2007, 8:398-408. 10.1038/ni1447, 17334368.
26. Eisen HN. Specificity and degeneracy in antigen recognition: yin and yang in the immune system. Annu Rev Immunol 2001, 19:1-21. 10.1146/annurev.immunol.19.1.1, 11244028.
27. Robertson JM, Jensen PE, Evavold BD. DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope. J Immunol 2000, 164:4706-12.