Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands

Clinical Cancer Research

Volumn 17, Issue 9, 2011, Pages 2842-2851

  Zheng, Changyu ^a   Cotrim, Ana P ^a   Rowzee, Anne ^a   Swaim, William ^a   Sowers, Anastasia ^b   Mitchell, James B ^b   Baum, Bruce J ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; KERATINOCYTE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG TISSUE LEVEL; ENDOTHELIUM CELL; FEMALE; FLOW RATE; GENE CONSTRUCT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIATION PROTECTION; SALIVARY GLAND DISEASE; SALIVARY HYPOFUNCTION; SALIVATION; SEROTYPE; SQUAMOUS CELL CARCINOMA; STEM CELL; SUBMANDIBULAR GLAND; TREATMENT DURATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CARCINOMA; FEMALE; FIBROBLAST GROWTH FACTOR 7; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEAD AND NECK NEOPLASMS; HUMANS; MICE; MICE, INBRED C3H; RADIATION INJURIES, EXPERIMENTAL; RADIOTHERAPY; RECOMBINANT PROTEINS; SALIVARY GLAND DISEASES; SALIVARY GLANDS; SUBMANDIBULAR GLAND; TUMOR CELLS, CULTURED;

EID: 79955511901     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-2982     Document Type: Article

References (35)

1. Vissink A, Jansma J, Spijkervet FKL, Burlage FR, Coppes RP. Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med 2003;14:199-212. (Pubitemid 44560804)
2. Vissink A, Burlage FR, Spijkervet FKL, Jansma J, Coppes RP. Prevention and treatment of the consequences of head and neck radiotherapy. Crit Rev Oral Biol Med 2003;14:213-25. (Pubitemid 44560805)
3. Langendijk JA, Doornaert P, Verdonck-de Leeuw IM, Leemans CR, Aaronson NK, Slotman BJ. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol 2008;26:3770-6.
4. Ho KF, Farnell DJJ, Routledge JA, Burns MP, Sykes AJ, Slevin NJ, et al. Developing a CTCAEs patient questionnaire for late toxicity after head and neck radiotherapy. Eur J Cancer 2009;45:1992-8.
5. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 1989;245:752-5. (Pubitemid 19214010)
6. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A 1989;86: 802-6. (Pubitemid 19056244)
7. Miki T, Fleming TP, Bottaro DP, Rubin JS, Ron D, Aaronson SA. Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science 1991;251:72-5. (Pubitemid 21916854)
8. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM, et al. Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A 1992;89:246-50.
9. Cheon HG, LaRochelle WJ, Bottaro DP, Burgess WH, Aaronson SA. High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains. Proc Natl Acad Sci U S A 1994;91:989-93. (Pubitemid 24048494)
10. Yildirim AO, Muyal V, John G, Müller B, Seifart C, Kasper M, et al. Palifermin induces alveolar maintenance programs in emphysematous mice. Am J Respir Crit Care Med 2010;181:705-17.
11. Panoskaltsis-Mortari A, Taylor PA, Rubin JS, Uren A, Welniak LA, Murphy WJ, et al. Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury. Blood 2000;96:4350-6.
12. Finch PW, Rubin JS. Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res 2004;91:69-136. (Pubitemid 39140957)
13. Chen L, Brizel DM, Rabbani ZN, Samulski TV, Farrell CL, Larrier N, et al. The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. Int J Radiat Oncol Biol Phys 2004;60:1520-9. (Pubitemid 39601870)
14. Farrell CL, Bready JV, Rex KL, Chen JN, DiPalma CR, Whitcomb KL, et al. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 1998;58:933-9. (Pubitemid 28182461)
15. Farrell CL, Rex KL, Kaufman SA, Dipalma CR, Chen JN, Scully S, et al. Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice. Int J Radiat Biol 1999;75:609-20. (Pubitemid 29243139)
16. Yi ES, Williams ST, Lee H, Malicki DM, Chin EM, Yin S, et al. Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol 1996;149:1963-70. (Pubitemid 26415215)
17. Gibson RJ, Bowen JM, Keefe DM. Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats. Int J Cancer 2005;116:464-70. (Pubitemid 40993345)
18. Baba Y, Yazawa T, Kanegae Y, Sakamoto S, Saito I, Morimura N, et al. Keratinocyte growth factor gene transduction ameliorates acute lung injury and mortality in mice. Hum Gene Ther 2007;18:130-41. (Pubitemid 46446050)
19. Zheng C, Cotrim AP, Sunshine AN, Sugito T, Liu L, Sowers A, et al. Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands. Clin Cancer Res 2009;15:4641-8.
20. Zheng C, Vitolo JM, Zhang W, Mineshiba F, Chiorini JA, Baum BJ. Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements. Mol Ther 2008;16:1089-97. (Pubitemid 351737074)
21. Amalfitano A, Chamberlain JS. Isolation and characterization of packaging cell lines that coexpress the adenovirus E1, DNA polymerase, and preterminal protein: implication for gene therapy. Gene Ther 1996;4:258-63.
22. Baum BJ, Wellner RB, Zheng C. Gene transfer to salivary glands. Int Rev Cytol 2002;213:93-146. (Pubitemid 34112917)
23. Adesanya MR, Redman RS, Baum BJ, O'Connell BC. Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Human Gene Ther 1996;7:1085-93. (Pubitemid 26202726)
24. Muanza TM, Cotrim AP, McAuliffe M, Sowers AL, Baum BJ, Cook JA, et al. Evaluation of radiation-induced oral mucositis by optical coherence tomography. Clin Cancer Res 2005;11:5121-7. (Pubitemid 41003696)
25. Cotrim AP, Hyodo F, Matsumoto K, Sowers AL, Cook JA, Baum BJ, et al. Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clin Cancer Res 2007;13:4928-33. (Pubitemid 47294801)
26. Itoh N, Ornitz DM. Evolution of the FGF and FGFR gene families. Trends Genet 2004;20:563-9. (Pubitemid 39314564)
27. Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol 2001;2: REVIEWS3005.
28. Cotrim AP, Sowers A, Mitchell JB, Baum BJ. Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther 2007;15:2101-6. (Pubitemid 350148925)
29. Xu J, Yan X, Gao R, Mao L, Cotrim AP, Zheng C, et al. Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig. Int J Radiat Oncol Biol Phys 2010;78:897-903.
30. Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP. Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool. Stem Cells 2008;26:2595-601.
31. O'Connell BC, Zheng C, Jacobson-Kram D, Baum BJ. Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats. J Oral Pathol Med 2003;32:414-21. (Pubitemid 36885755)
32. Zheng C, Voutetakis A, Kok MR, Goldsmith CM, Smith GB, Elmore S, et al. Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland. Oral Dis 2006;12:137-44.
33. Zheng C, Goldsmith CM, Mineshiba F, Chiorini JA, Kerr A, Wenk ML, et al. Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland. Hum Gene Ther 2006;17:1122-33. (Pubitemid 44749713)
34. Baum BJ, Zheng C, Alevizos I, Cotrim AP, Liu S, McCullagh L, et al. Development of a gene transfer-based treatment for radiation-induced salivary hypofunction. Oral Oncol 2010;46:4-8.
35. Zheng C, Nikolov NP, Alevizos I, Cotrim AP, Liu S, McCullagh L, et al. Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland. J Gene Med 2010;12:3-10.