Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland

Journal of Gene Medicine

Volumn 12, Issue 1, 2010, Pages 3-10

  Zheng, Changyu ^a   Nikolov, Nikolay P ^a   Alevizos, Ilias ^a   Cotrim, Ana P ^a   Liu, Shuying ^a   McCullagh, Linda ^a   Chiorini, John A ^a   Illei, Gabor G ^a   Baum, Bruce J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Adenoviral vector; Clinical trial; E1 gene; Parotid gland; Saliva

Indexed keywords

ADENOVIRUS VECTOR; AQUAPORIN 1; GLYCOPROTEIN E1; LUCIFERASE; NEUTRALIZING ANTIBODY; VIRUS DNA;

ADENOVIRUS 5; ADENOVIRUS INFECTION; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; DNA EXTRACTION; GENE SEQUENCE; HUMAN; HUMAN CELL; MALE; NUCLEOTIDE SEQUENCE; PAROTID GLAND; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; REAL TIME POLYMERASE CHAIN REACTION; SALIVA; SALIVA ANALYSIS; SALIVARY GLAND DISEASE; SALIVARY GLAND HYPOFUNCTION; SIALOADENITIS; VIRAL GENE DELIVERY SYSTEM; VIRUS DETECTION; VIRUS GENE;

ADENOVIRIDAE; ADENOVIRUS E1 PROTEINS; AQUAPORIN 1; BASE SEQUENCE; DNA, VIRAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PAROTID GLAND; POLYMERASE CHAIN REACTION; SALIVA; SEQUENCE ANALYSIS, DNA; TIME FACTORS;

ADENOVIRIDAE;

EID: 75449088599     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1416     Document Type: Article

References (26)

1. Cox JD, Steitz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for research and treatment of cancer. Int J Radiat Oncol Biol Phys 1995; 31: 1341-1346.
2. Baum BJ. Principles of saliva secretion. Ann NY Acad Sci 1993; 694: 17-23.
3. Vitolo JM, Baum BJ. The use of gene transfer for the protection and repair of salivary glands. Oral Dis 2002; 8: 183-191.
4. Vissink A, Jansma J, Spijkervet FK, et al. Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med 2002; 14: 199-212.
5. Preston GM, Agre P. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kDa: member of an ancient channel family. Proc Natl Acad Sci USA 1991; 88: 11110-11114.
6. Delporte C, O'Connell BC, He X, et al. Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci USA 1997; 94: 3268-3273.
7. Shan Z, Li J, Zheng C, et al. Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol Ther 2005; 11: 444-451.
8. Sprangers MC, Lakhal W, Koudstaal W, et al. Quantifying adenovirus-neutralizing antibodies by luciferase transgene detection: addressing pre-existing immunity to vaccine and gene therapy vectors. J Clin Microbiol 2003; 41: 5046-5052.
9. Zheng C, Vitolo JM, Zhang W, et al. Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements. Mol Ther 2008; 16: 1089-1097.
10. Ship JA, Fox PC, Baum BJ. How much saliva is enough? Normal function defined. J Am Dent Assoc 1991; 122: 63-69.
11. Gelfand MS, Cleveland KO, Lancaster D, et al. Adenovirus parotitis in patients with AIDS. Clin Infect Dis 1994; 19: 1045-1048.
12. D'Ambrosio E, Del Grosso N, Chicca A, Midulla M. Neutralizing antibodies against 33 human adenoviruses in normal children in Rome. J Hygiene 1982; 89: 155-161.
13. Chirmule N, Propert KJ, Magosin SA, et al. Immune responses to adénovirus and adeno-associated virus in humans. Gene Ther 1999; 1574-1583.
14. Nwanegbo E, Vardas E, Gao W, et al. Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa and the United States. Clin Diag Lab Immunol 2002; 11: 351-357.
15. Xiang Z, Li Y, Cun A, et al. Chimpanzee adénovirus antibodies in humans, sub-Saharan Africa. Emerg Infect Dis 2006; 1596-1599.
16. Humar A. Reactivation of viruses in solid organ transplant patients receiving cytomegalovirus prophylaxis. Transplantation 2006; 82: S9-S14.
17. Durepaire N, Ranger-Rogez S, Gandji JA, et al. Enteric prevalence of adenovirus in human immunodeficiency patients. J Med Virol 1995; 45: 56-60.
18. Higashimoto Y, Elliott WM, Behzad AR, et al. Inflammatory mediator mRNA expression by adenovirus E1A-transfected bronchial epithelial cells. Am J Respir Crit Care Med 2002; 166: 200-207.
19. Leen A, Ratnayake M, Foster A, et al. Contact-activated monocyt: efficient antigen presenting cells for the stimulation of antigen-specific T cells. J Immunother 2007; 30: 96-107.
20. Metcalf JP, Monick MM, Stinski MF, et al. Adenovirus E1A 13S gene product up-regulates the cytomegalovirus major intermediate early promoter. Am J Respir Cell Mol Biol 1994; 10: 448-452.
21. Westphal E-M, Mauser A, Swenson J, et al. Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo. Cancer Res 1999; 59: 1485-1491.
22. Reischig T, Opatrny Jr K, Treska V, et al. Prospective comparison of valacyclovir aand oral ganciclovir for the prevention of cytomegalovirus disease in high-risk renal transplant patients. Kidney Blood Press Res 2005; 28: 218-225.
23. Yeh C-K, Handelman B, Fox PC, Baum BJ. Further studies of salivary inhibition of HIV-1 infectivity. J Acquir Immune Defic Syndr 1992; 5: 898-903.
24. Bergey EJ, Gu M, Collins AR, et al.Modulation of herpes simplex virus type 1 replication by human salivary secretions. Oral Microbiol Immunol 1993; 8: 89-93.
25. Drobni P, Naslund J, Evander M. Lactoferrin inhibits human papillomavirus binding and uptake in vitro. Antiviral Res 2004; 64: 63-68.
26. White MR, Helmerhorst EJ, Ligtenberg, et al. Multiple components contribute to ability of saliva to inhibit influenza viruses. Oral Microbiol Immunol 2009; 24: 18-24.