Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland

Human Gene Therapy

Volumn 17, Issue 11, 2006, Pages 1122-1133

  Zheng, Changyu ^a   Goldsmith, Corinne M ^a   Mineshiba, Fumi ^a   Chiorini, John A ^a   Kerr, Andrew ^b   Wenk, Martin L ^b   Vallant, Molly ^c   Irwin, Richard D ^c   Baum, Bruce J ^a,d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b Toxicology Division   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 1; GENE PRODUCT; NATURAL PRODUCT; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ADENOVIRUS 5; ADENOVIRUS VECTOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CANNULATION; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG DISTRIBUTION; FEMALE; FLUID INTAKE; FOOD INTAKE; HEART FUNCTION; HEMATOCRIT; HUMAN; INFLAMMATION; KIDNEY FUNCTION; LIVER FUNCTION; MALE; MORBIDITY; MORTALITY; NONHUMAN; RADIATION INJURY; RAT; RETRODUCTAL DRUG ADMINISTRATION; SALIVA ANALYSIS; SALIVARY GLAND DISEASE; SEX DIFFERENCE; TREATMENT RESPONSE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS DETECTION; VIRUS PARTICLE; VIRUS RECOMBINANT; WEIGHT GAIN;

ADENOVIRIDAE; ANIMALS; ANTIBODIES; AQUAPORIN 1; DRUG ADMINISTRATION ROUTES; FEMALE; GENE EXPRESSION; GENETIC VECTORS; MALE; RATS; RECOMBINANT PROTEINS; SUBMANDIBULAR GLAND; TISSUE DISTRIBUTION; TRANSGENES;

ADENOVIRIDAE; ANIMALIA;

EID: 33751008677     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2006.17.1122     Document Type: Article

References (30)

1. ADESANYA, M.R., REDMAN, R.S., BAUM, B.J., and O'CONNELL, B.C. (1996). Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Hum. Gene Ther. 7, 1085-1093.
2. AGRE, P., PRESTON, G.M., SMITH, B.L., JUNG, J.S., RAINA, S., MOON, C., GUGGINO, W.B., and NIELSEN, S. (1993). Aquaporin CHIP: The archetypal molecular water channel. Am. J. Physiol. 265, F463-F476.
3. BACCAGLINI, L., HOQUE, A.T.M.S., WELLNER, R.B., GOLDSMITH, C.M., REDMAN, R.S., SANKAR, V., KINGMAN, A., BARNHART, K.M., WHEELER, C.J., and BAUM, B.J. (2001). Cationic liposome mediated gene transfer to rat salivary epithelial cells in vitro and in vivo. J. Gene Med. 3, 82-90.
4. BAUM, B.J., WELLNER, R.B., and ZHENG, C. (2002). Gene transfer to salivary glands. Int. Rev. Cytol. 213, 93-146.
5. BJÖRDAL, K., AHLNER-ELMQVIST, M., HAMMERLID, E., BOYSEN, M., EVENSEN, J.F., BJORKLUND, A., JANNERT, M., WESTIN, T., and KAASA, S. (2001). A prospective study of quality of life in head and neck cancer patients. II. Longitudinal data. Laryngoscope 111, 1440-1452.
6. CHAMBERS, M.S., GARDEN, A.S., KIES, M.S., and MARTIN, J.W. (2004). Radiation-induced xerostomia in patients with head and neck cancer: Pathogenesis, impact on quality of life, and management. Head Neck 26, 796-806.
7. DELPORTE, C., O'CONNELL, B.C., HE, X., LANCASTER, H.E., O'CONNELL, A.C., AGRE, P., and BAUM, B.J. (1997). Increased fluid secretion alter adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc. Natl. Acad. Sci. U.S.A. 94, 3268-3273.
8. DELPORTE, C., MILLER, G., KAGAMI, H., LILLIBRIDGE, C.D., O'CONNELL, B.C., ATKINSON, J.C., and BAUM, B.J. (1998). Safety of salivary gland-administered replication-deficient recombinant adenovirus in rats. J. Oral Pathol. Med. 27, 34-38.
9. -] adenovirus-mediated transfer of human acid-α-glucosidase gene into glycogen storage disease type II knockout mice. Hum. Gene Ther. 12, 955-965.
10. EHRHARDT, A., and KAY, M.A. (2002). A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo. Blood 99, 3923-3930.
11. GONIN, P., and GAILLARD, C. (2004). Gene transfer vector biodistribution: Pivotal safety studies in clinical gene therapy development. Gene Ther. 11, S98-S108.
12. CChCLN2, a candidate treatment for the central nervous system manifestations of late infantile neuronal ceroid lipofuscinosis, to the hrain of rats and non-human primates. Hum. Gene Ther. 16, 1484-1503.
13. LI, J., NIELSEN, S., DAI, Y., LAZOWSKI, K.W., CHRISTENSEN, E.I., TABAK, L.A., and BAUM, B.J. (1994). Examination of rat salivary glands for the presence of the aquaporin CHIP. Pflugers Arch. 428, 455-400.
14. LI, J., ZHENG, C.Y., ZHANG, X., LIU, X., ZHANG, C., GOLDSMITH, C.M., BAUM, B.J., and WANG, S. (2004). Developing a convenient large animal model for gene transfer to salivary glands in vivo. J. Gene. Med. 6, 55-63.
15. LÖSER, P., JENNINGS, G.S., STRAUSS, M., and SANDIG, V. (1998). Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: Involvement of NFκB. J. Virol. 72, 180-190.
16. MASTRANGELI, A., O'CONNELL, B., ALADIB, W., FOX, P.C., BAUM, B.J., and CRYSTAL, R.G. (1994). Direct in vivo adenovirus-mediated gene transfer to salivary glands. Am. J. Physiol. 266, G11460-G1155.
17. NAGLER, R.M., and BAUM, B.J. (2003). Prophylactic treatment reduces the severity of xerostomia following irradiation therapy for oral cavity cancer. Arch. Otolaryngol. Head Neck Surg. 129, 247-250.
18. O'CONNELL, A.C., BACCAGLINI, L., FOX, P.C., O'CONNELL, B.C., KENSHALO, D., OWEISY, H., HOQUE, A.T., SUN, D., HERSCHER, L.L., BRADDON, V.R., DELPORTE, C., and BAUM, B.J. (1999). Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates. Canecr Gene Ther. 6, 505-513.
19. O'CONNELL, B.C., ZHENG, C., JACOBSON-KRAM, D., and BAUM, B.J. (2003). Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats. J. Oral Pathol. Med. 32, 414-421.
20. PRESTON, G.M., and AGRE, P. (1991). Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: Member of an ancient channel family. Proc. Natl. Acad. Sci. U.S.A. 88, 11110-11114.
21. RECOMBINANT DNA ADVISORY COMMITTEE. (2005). Minutes of Meeting, December 14-15, 2005. Available at http://www4.od.nih. gov/oba/rac/min/RAC_mm_12-05.pdf (accessed September 2006).
22. SHAN, Z., LIM, J., ZHENG, C., LIU, X., FAN, Z., ZHANG, C., GOLDSMITH, C.M., WELLNER, R.B., BAUM, B.J., and WANG, S. (2005). Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol. Ther. 11, 444-451.
23. SPRANGERS, M.C., LAKHAI, W., KOUDSTAAL, W., VERHOEVEN, M., KOEL, B.J., VOGELS, R., GOUDSMIT, J., HAVENGA, M.J.E., and KOSTENSE, S. (2003). Quantifying adenovirus-neutralizing antibodies by luciferase transgene detection: Addressing pre-existing immunity to vaccine and gene therapy vectors. J. Clin. Microbiol. 41, 5046-5052.
24. TERRELL, J.E., RONIS, D.L., FOWLER, K.E., BRADFORD, C.R., CHEPEHA, D.B., PRINCE, M.E., TEKNOS, T.N., WOLF, G.T., and DUFFY, S.A. (2004). Clinical predictors of quality of life in patients with head and neck cancer. Arch. Otolaryngol. Head Neck Surg. 130, 401-408.
25. VAN LINTHOUT, S., LUSKY, M., COLLEN, D., and DE GEEST, B. (2002). Persistent hepatic expression of human apo A-1 after transfer with a helper-virus independent adenoviral vector. Gene Ther. 9, 1520-1528.
26. VAN NIEUW AMERONGEN, A.V., and VEERMAN, E.C.I. (2002). Saliva-defender of the oral cavity. Oral Dis. 8, 12-22.
27. VISSINK, A., JANSMA, J., SPIJKERVET, F.K., BURLAGE, F.R., and COPPES, R.P. (2003a). Oral sequelae of head and neck radiotherapy. Crit. Rev. Oral Biol. Med. 14, 199-212.
28. VISSINK, A., BURLAGE, F.R., SPIJKERVET, F.K., JANSMA, J., and COPPES, R.P. (2003b). Prevention and treatment of the consequences of head and neck radiotherapy. Crit. Rev. Oral Biol. Med. 14, 213-225.
29. WANG, J., VOUTETAKIS, A., MINESHIBA, F., ILLEI, G.G., DANG, H., YEH, C.-K., and BAUM, B.J. (2006). The effect of serotype 5 adenoviral and serotype 2 adeno-associated viral vector-mediated gene transfer to salivary glands on the composition of saliva. Hum. Gene Ther. 17, 455-463.
30. ZHENG, C., VOUTETAKIS, A., KOK, M.R., GOLDSMITH, C.M., SMITH, G.B.J., VALLANT, M., IRWIN, R.D., and BAUM, B.J. (2006). Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandihular gland. Oral Dis. 12, 137-144.