The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats

International Journal of Radiation Oncology Biology Physics

Volumn 60, Issue 5, 2004, Pages 1520-1529

  Chen, Liguang ^a   Brizel, David M ^a   Rabbani, Zahid N ^a   Samulski, Thaddeus V ^a   Farrell, Catherine L ^b   Larrier, Nicole ^a   Anscher, Mitchell S ^a   Vujaskovic, Zeljko ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b AMGEN INC   (United States)

Author keywords

Fibrosis; Pneumonitis; Radiation; rHuKGF; TGF

Indexed keywords

BREATHING RATE; LING INJURIES; RECOMBINANT HUMAN KERATINOCYTE GROWTH FACTORS (RHUKGF); THORACIC TUMORS;

GROWTH KINETICS; IMMUNOLOGY; IRRADIATION; TOXICITY; TUMORS;

PULMONARY DISEASES;

BETA6 INTEGRIN; DRUG VEHICLE; RECOMBINANT KERATINOCYTE GROWTH FACTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG MEGADOSE; FEMALE; IMMUNOREACTIVITY; INJECTION; IRRADIATION; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG INJURY; LUNG TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIATION PROTECTION; RAT; RAT STRAIN;

ANIMALS; FEMALE; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; HUMANS; LUNG; RADIATION INJURIES, EXPERIMENTAL; RADIATION PNEUMONITIS; RADIATION-PROTECTIVE AGENTS; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; RESPIRATION;

EID: 10044275308     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.07.729     Document Type: Article

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