Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland

Oral Diseases

Volumn 12, Issue 2, 2006, Pages 137-144

  Zheng, C ^a   Voutetakis, A ^a   Kok, M R ^a,b   Goldsmith, C M ^a   Smith, G B J ^c   Elmore, S ^d   Nyska, A ^e   Vallant, M ^e   Irwin, R D ^e   Baum, B J ^a,f  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c BioReliance   (United States)

^d INTEGRATED LABORATORY SYSTEMS   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Adenovirus; Gene therapy; Hydroxychloroquine; Safety; Salivary gland

Indexed keywords

HUMAN GROWTH HORMONE; HYDROXYCHLOROQUINE; SERUM GLOBULIN;

ADENOVIRUS VECTOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD ANALYSIS; BLOOD FLOW; BLOOD LEVEL; CLINICAL CHEMISTRY; CLINICAL FEATURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG DISTRIBUTION; DRUG EFFECT; EVALUATION; EXPRESSION VECTOR; FEMALE; FLUID INTAKE; FOOD INTAKE; GENETIC TRANSFECTION; GONAD; GROWTH HORMONE DEFICIENCY; HEART; HISTOLOGY; HORMONE BLOOD LEVEL; HORMONE RELEASE; MALE; NONHUMAN; ORGAN; PARAMETER; PATHOLOGY; PRIORITY JOURNAL; RAT; SALIVA LEVEL; SALIVARY GLAND; SEROTYPE; SINGLE DRUG DOSE; SUBMANDIBULAR GLAND; TISSUE DISTRIBUTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT; VIRUS REPLICATION; WEIGHT CHANGE;

ADENOVIRIDAE; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; AMYLASES; ANIMALS; ANTIRHEUMATIC AGENTS; FEMALE; GENETIC VECTORS; HUMAN GROWTH HORMONE; HUMANS; HYDROXYCHLOROQUINE; L-LACTATE DEHYDROGENASE; MALE; PLASMIDS; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; SERUM GLOBULINS; SUBMANDIBULAR GLAND; TISSUE DISTRIBUTION; VIRUS REPLICATION;

EID: 33645110519     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2005.01170.x     Document Type: Article

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