Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats

Journal of Oral Pathology and Medicine

Volumn 32, Issue 7, 2003, Pages 414-421

  O'Connell, Brian C ^a,b   Zheng, Changyu ^a   Jacobson Kram, David ^c   Baum, Bruce J ^a,d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c BioReliance   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Adenovirus; Gene transfer; Safety; Salivary, submandibular

Indexed keywords

ADENOVIRUS VECTOR; HISTATIN; HISTATIN 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISTRIBUTION; FEMALE; FOOD INTAKE; GENE TRANSFER; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; RAT; SAFETY; SALIVA LEVEL; SALIVARY GLAND; SUBMANDIBULAR GLAND; SURVIVAL; TOXICITY TESTING; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT; WEIGHT GAIN;

ADENOVIRIDAE; ANIMALS; BLOOD CHEMICAL ANALYSIS; EATING; FEMALE; GENETIC VECTORS; GLYCOPROTEINS; HUMANS; MALE; PROTEINS; RANDOM ALLOCATION; RATS; RECOMBINANT PROTEINS; SALIVA; SALIVARY PROTEINS; SUBMANDIBULAR GLAND; TISSUE DISTRIBUTION; WEIGHT GAIN;

EID: 0038372164     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0714.2003.t01-1-00004.x     Document Type: Article

References (22)

1. Baum BJ, Wellner RB, Zheng C. Gene transfer to salivary glands. Int Rev Cytol 2002; 213: 93-146.
2. Delporte C, O'Connell BC, He X, et al. Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci USA 1997; 94: 3268-73.
3. Hoque ATMS, Baccaglini L, Baum BJ. Hydroxychloroquine enhances the endocrine secretion of adenovirus-directed growth hormone from rat submandibular glands in vivo. Hum Gene Ther 2001; 12: 1333-42.
4. O'Connell BC, Xu T, Walsh TJ, et al. Transfer of a gene encoding the anticandidal protein histatin 3 to salivary glands. Hum Gene Ther 1996; 7: 2255-61.
5. Delporte C, Redman RS, Baum BJ. Relationship between the cellular distribution of the alpha (v) beta3/5 integrins and adenoviral infection in salivary glands. Laboratory Invest 1997; 77: 167-73.
6. Lusky M, Christ M, Rittner K, et al. In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted. J Virol 1998; 72: 2022-32.
7. Hackett NR, Kaminsky SM, Sondhi D, Crystal RG. Antivector and antitransgene host responses in gene therapy. Curr Opin Mol Ther 2000; 2: 376-82.
8. Schnell MA, Zhang Y, Talezaar J, et al. Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther 2001; 3: 708-22.
9. Adesanya MR, Redman RS, Baum BJ, O'Connell BC. Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Hum Gene Ther 1996; 7: 1085-93.
10. Kagami H, Atkinson JC, Michalek SM, et al. Repetitive adenovirus administration to the parotid gland. Role of immunological barriers and induction of oral tolerance. Hum Gene Ther 1998; 9: 305-13.
11. Harvey B-G, Maroni J, O'Donohughe KA, et al. Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions. Hum Gene Ther 2002; 13: 15-63.
12. Zoltick PW, Chirmule N, Schnell MA, Gao G-P, Hughes JV, Wilson JM. Biology of El-deleted adenovirus vectors in nonhuman primate muscle. J Virol 2001; 75: 5222-9.
13. Glover CP, Bienemann AS, Heywood DJ, Cosgrave AS, Uney JB. Adenoviral-mediated high-level, cell-specific transgene expression: a SYN1-WPRE cassette mediates increased transgene expression with no loss of neuron specificity. Mol Ther 2002; 5: 509-16.
14. De Geest B, Van Linthout S, Collen D. Sustained expression of human apo A-1 following adenoviral gene transfer in mice. Gene Ther 2001; 8: 121-7.
15. Van Linthout S, Collen D, De Geest B. Effect of promoters and enhancers on expression, transgene DNA persistence, and hepatotoxicity after adenoviral gene transfer of human apolipoprotein A-1. Hum Gene Ther 2002; 13: 829-40.
16. Mastrangeli A, O'Connell B, Aladib W, Fox PC, Baum BJ, Crystal RG. Direct in vivo adenovirus-mediated gene transfer to salivary glands. Am J Physiol 1994; 266: G1146-55.
17. Van Der Speck JC, Offner GD, Troxler RF, Oppenheim FG. Molecular cloning of human submandibular gland histatins. Archs Oral Biol 1990; 35: 137-43.
18. Mei YF, Lindman K, Wadell G. Human adenoviruses of subgenera B, C, E with various tropisms differ in both binding to and replication in the epithelial A549 and 293 cells. Virology 2002; 295: 30-43.
19. Delporte C, Miller G, Kagami H, et al. Safety of salivary gland-administered replication-deficient recombinant adenovirus in rats. J Oral Pathol Med 1998; 27: 34-8.
20. Kagami H, O'Connell BC, Baum BJ. Evidence for the systemic delivery of a transgene product from salivary glands. Hum Gene Ther 1996; 7: 2177-84.
21. Baccaglini L, Hoque ATMS, Wellner RB, et al. Cationic liposome-mediated gene transfer to rat salivary epithelial cells in vitro and in vivo. J Gene Med 2001; 3: 82-90.
22. Zheng C, Hoque ATMS, Braddon VR, Baum BJ, O'Connell BC. Evaluation of salivary gland acinar and ductal cell-specific promoters in vivo with recombinant adenoviral vectors. Hum Gene Ther 2001; 12: 2215-23.