α-Melanocyte-stimulating hormone inhibits tumor necrosis factor α-stimulated MUC5AC expression in human nasal epithelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 44, Issue 5, 2011, Pages 716-724

  Lee, Sang Nam ^a   Ryu, Ji Hwan ^a   Joo, Jung Hee ^a   Choi, Yeon Ho ^a   Lee, Hyun Jae ^a   Kim, Yoon Ju ^a   Kim, Kyu Bo ^a   Yoon, Joo Heon ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

MSH; MC 1R; Mucin; NF B pathway; TNF

Indexed keywords

ALPHA INTERMEDIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MELANOCORTIN 1 RECEPTOR; MUCIN 5AC; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; SECRETOGRANIN V; SHORT HAIRPIN RNA; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL ACTIVATION; CELL LABELING; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LENTIVIRINAE; NOSE MUCOSA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA-MSH; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; LENTIVIRUS; MELANOCYTES; MODELS, BIOLOGICAL; MUCIN 5AC; NF-KAPPA B; NOSE; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 1; TUMOR NECROSIS FACTOR-ALPHA;

LENTIVIRUS;

EID: 79955507341     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0420OC     Document Type: Article

References (44)

1. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 2006;86:245-278.
2. Thai P, Loukoianov A, Wachi S, Wu R. Regulation of airway mucin gene expression. Annu Rev Physiol 2008;70:405-429. (Pubitemid 351738186)
3. Linden SK, Sutton P, Karlsson NG, Korolik V, McGuckin MA. Mucins in the mucosal barrier to infection. Mucosal Immunol 2008;1:183-197. (Pubitemid 351541304)
4. Seidah NG, Benjannet S, Hamelin J, Mamarbachi AM, Basak A, Marcinkiewicz J, Mbikay M, Chretien M, Marcinkiewicz M. The subtilisin/kexin family of precursor convertases: emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Ann N Y Acad Sci 1999;885:57-74.
5. Blalock JE. Proopiomelanocortin and the immune-neuroendocrine connection. Ann N Y Acad Sci 1999;885:161-172.
6. Chakraborty AK, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek JM, Ichihashi M. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. Biochim Biophys Acta 1996;1313:130-138. (Pubitemid 26276211)
7. Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 2000;80:979-1020. (Pubitemid 30452009)
8. Slominski A, Wortsman J. Neuroendocrinology of the skin. Endocr Rev 2000;21:457-487.
9. Star RA, Rajora N, Huang J, Stock RC, Catania A, Lipton JM. Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte- stimulating hormone. Proc Natl Acad Sci USA 1995;92:8016-8020.
10. Wakamatsu K, Graham A, Cook D, Thody AJ. Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res 1997;10:288-297. (Pubitemid 127524305)
11. Catania A. Neuroprotective actions of melanocortins: a therapeutic opportunity. Trends Neurosci 2008;31:353-360.
12. Brzoska T, Luger TA, Maaser C, Abels C, Bohm M. α-melanocyte- stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev 2008;29:581-602.
13. Catania A, Gatti S, Colombo G, Lipton JM. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 2004;56:1-29. (Pubitemid 38314578)
14. Suzuki I, Cone RD, Im S, Nordlund J, Abdel-Malek ZA. Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 1996;137:1627-1633. (Pubitemid 26133934)
15. Moustafa M, Szabo M, Ghanem GE, Morandini R, Kemp EH, MacNeil S, Haycock JW. Inhibition of tumor necrosis factor-α stimulated NFκB /p65 in human keratinocytes by α-melanocyte stimulating hormone and adrenocorticotropic hormone peptides. J Invest Dermatol 2002;119:1244-1253. (Pubitemid 36005605)
16. Neumann Andersen G, Nagaeva O, Mandrika I, Petrovska R, Muceniece R, Mincheva-Nilsson L, Wikberg JE. MC1 receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions. Clin Exp Immunol 2001;126:441-446. (Pubitemid 34008716)
17. Scholzen TE, Brzoska T, Kalden DH, Hartmeyer M, Fastrich M, Luger TA, Armstrong CA, Ansel JC. Expression of functional melanocortin receptors and proopiomelanocortin peptides by human dermal microvascular endothelial cells. Ann N Y Acad Sci 1999;885:239-253.
18. Bohm M, Schulte U, Kalden H, Luger TA. Alpha-melanocyte-stimulating hormone modulates activation of NFκB and AP-1 and secretion of interleukin-8 in human dermal fibroblasts. Ann N Y Acad Sci 1999;885:277-286.
19. Manna SK, Aggarwal BB. α-melanocyte-stimulating hormone inhibits the nuclear transcription factor NFκB activation induced by various inflammatory agents. J Immunol 1998;161:2873-2880. (Pubitemid 28425709)
20. Kalden DH, Scholzen T, Brzoska T, Luger TA. Mechanisms of the antiinflammatory effects of α-MSH: role of transcription factor NFκB and adhesion molecule expression. Ann N Y Acad Sci 1999;885:254-261.
21. Hill RP, MacNeil S, Haycock JW. Melanocyte stimulating hormone peptides inhibit TNF-α signaling in human dermal fibroblast cells. Peptides 2006;27:421-430. (Pubitemid 43162914)
22. Brzoska T, Kalden DH, Scholzen T, Luger TA. Molecular basis of the α /IL-1 antagonism. Ann N Y Acad Sci 1999;885:230-238.
23. Mandrika I, Muceniece R, Wikberg JE. Effects of melanocortin peptides on lipopolysaccharide/interferon-gamma-induced NF-kappaB DNA binding and nitric oxide production in macrophage-like raw 264.7 cells: evidence for dual mechanisms of action. Biochem Pharmacol 2001;61:613-621. (Pubitemid 32178496)
24. Etemad-Moghadam B, Chen H, Yin P, Aziz N, Hedley ML. Inhibition of NFκB activity by plasmid expressed a peptide. J Neuroimmunol 2002;125:23-29. (Pubitemid 34327450)
25. Raap U, Brzoska T, Sohl S, Path G, Emmel J, Herz U, Braun A, Luger T, Renz H. α-melanocyte-stimulating hormone inhibits allergic airway inflammation. J Immunol 2003;171:353-359. (Pubitemid 36745308)
26. Martinez-Anton A, Debolos C, Garrido M, Roca-Ferrer J, Barranco C, Alobid I, Xaubet A, Picado C, Mullol J. Mucin genes have different expression patterns in healthy and diseased upper airway mucosa. Clin Exp Allergy 2006;36:448-457.
27. Chung KF. Inflammatory mediators in chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy 2005;4:619-625. (Pubitemid 41722372)
28. Lora JM, Zhang DM, Liao SM, Burwell T, King AM, Barker PA, Singh L, Keaveney M, Morgenstern J, Gutierrez-Ramos JC, et al. Tumor necrosis factor-α triggers mucus production in airway epithelium through an IκB kinase β-dependent mechanism. J Biol Chem 2005; 280:36510-36517. (Pubitemid 41633925)
29. Tsatmali M, Yukitake J, Thody AJ. ACTH 1-17 is a more potent agonist at the human MC1 receptor than α-MSH. Cell Mol Biol (Noisyle-grand) 1999;45:1029-1034.
30. Yoon JH, Kim KS, Kim HU, Linton JA, Lee JG. Effects of TNF-α and IL-1β on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells. Acta Otolaryngol 1999;119:905-910. (Pubitemid 30126643)
31. Schiller M, Raghunath M, Kubitscheck U, Scholzen TE, Fisbeck T, Metze D, Luger TA, Bohm M. Human dermal fibroblasts express prohormone convertases 1 and 2 and produce proopiomelanocortin-derived peptides. J Invest Dermatol 2001;117:227-235. (Pubitemid 34205705)
32. Andjelkov N, Elvenes J, Figenschau Y, Bjorkoy G, Knutsen G, Seternes T, Johansen O. Detection of mRNA transcripts of truncated opiate precursor (POMC) in human cartilage. Cell Biochem Funct 2006;24:229-235. (Pubitemid 43764459)
33. Hartmeyer M, Scholzen T, Becher E, Bhardwaj RS, Schwarz T, Luger TA. Human dermal microvascular endothelial cells express the melanocortin receptor type 1 and produce increased levels of IL-8 upon stimulation with α-melanocyte-stimulating hormone. J Immunol 1997;159:1930-1937. (Pubitemid 127484182)
34. Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH. Interleukin-1β and tumor necrosis factor-α induce MUC5AC over- expression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem 2003;278:23243-23250. (Pubitemid 36830137)
35. Wang X, Garrick MD, Yang F, Dailey LA, Piantadosi CA, Ghio AJ. TNF, IFN-γ, and endotoxin increase expression of DMT1 in bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2005;289:L24-L33. (Pubitemid 40863551)
36. Lerner AB, McGuire JS. Effect of α- and β-melanocyte stimulating hormones on the skin colour of man. Nature 1961;189:176-179.
37. 7]- α-MSH in humans. Photochem Photobiol 2000;72:526-532.
38. Eves P, Haycock J, Layton C, Wagner M, Kemp H, Szabo M, Morandini R, Ghanem G, Garcia-Borron JC, Jimenez-Cervantes C, et al. Antiinflammatory and anti-invasive effects of α-melanocyte-stimulating hormone in human melanoma cells. Br J Cancer 2003;89:2004-2015. (Pubitemid 37533283)
39. Yoon SW, Goh SH, Chun JS, Cho EW, Lee MK, Kim KL, Kim JJ, Kim CJ, Poo H. α-melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor- α production in leukocytes by modulating protein kinase a, p38 kinase, and nuclear factor κB signaling pathways. J Biol Chem 2003;278:32914-32920. (Pubitemid 37055734)
40. Kauser S, Thody AJ, Schallreuter KU, Gummer CL, Tobin DJ. A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes. Endocrinology 2005;146:532-543. (Pubitemid 40129807)
41. Rousseau K, Kauser S, Pritchard LE, Warhurst A, Oliver RL, Slominski A, Wei ET, Thody AJ, Tobin DJ, White A. Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J 2007;21:1844-1856. (Pubitemid 46855630)
42. Scamuffa N, Calvo F, Chretien M, Seidah NG, Khatib AM. Proprotein convertases: lessons from knockouts. FASEB J 2006;20:1954-1963. (Pubitemid 44953895)
43. Slominski A, Wortsman J, Mazurkiewicz JE, Matsuoka L, Dietrich J, Lawrence K, Gorbani A, Paus R. Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med 1993;122:658-666. (Pubitemid 2022717)
44. Catania A, Airaghi L, Manfredi MG, Vivirito MC, Milazzo F, Lipton JM, Zanussi C. Proopiomelanocortin-derived peptides and cytokines: relations in patients with acquired immunodeficiency syndrome. Clin Immunol Immunopathol 1993;66:73-79. (Pubitemid 23069258)