The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): Novel transcriptional co-regulators

Biochemical Society Transactions

Volumn 36, Issue 4, 2008, Pages 609-612

  Fuller Pace, Frances V ^a   Ali, Simak ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Co activator; DEAD box; p68; p72; RNA helicase; Transcriptional regulation

Indexed keywords

DEAD BOX PROTEIN; ESTROGEN RECEPTOR ALPHA; MYOD PROTEIN; PROTEIN P53; PROTEIN P68; PROTEIN P72; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; TUMOR SUPPRESSOR PROTEIN;

AMINO ACID SEQUENCE; CANCER GROWTH; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DNA DAMAGE; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RNA PROCESSING; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; DEAD-BOX RNA HELICASES; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; HUMANS; NEOPLASMS; TRANSCRIPTION, GENETIC;

EID: 49349104315     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360609     Document Type: Review

References (35)

1. Linder, P., Lasko, P.F., Leroy, P., Nielsen, P.J., Nishi, K., Schnier, J. and Slominski, P.P. (1989) Birth of the D-F-A-D box. Nature 337, 121-122
2. Lorsch, J.R. (2002) RNA chaperones exist and DEAD box proteins get a life. Cell 109, 797-800
3. Fuller-Pace, F.V. (2006) DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Nucleic Acids Res. 34, 4206-4215
4. Ford, MJ, Anton, I.A. and Lane, D.P. (1988) Nuclear protein with sequence homology to translation initiation factor eIF-4A. Nature 332, 736-738
5. Hirling, H., Scheffner, M., Restle, T. and Stahl, H. (1989) RNA helicase activity associated with the human p68 protein. Nature 339, 562-564
6. Lamm, G.M., Nicol, S.M., Fuller Pace, F.V. and Lamond, A.I. (1996) p72: a human nuclear DEAD box protein highly related to p68. Nucleic Acids Res. 24, 3739-3747
7. Ogilvie, V.C., Wilson, BJ., Nicol, S.M., Morrice, N.A., Saunders, L.R., Barber, G.N. and Fuller-Pace, F.V. (2003) The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells. Nucleic Acids Res. 31, 1470-1480
8. Rossler, O.G., Straka, A. and Stahl, H. (2001) Rearrangement of structured RNA via branch migration structures catalysed by the highly related DEAD-box proteins p68 and p72. Nucleic Acids Res. 29, 2088-2096
9. Stevenson, R.J., Hamilton, S.J., MacCallum, D.E., Hall, P.A. and Fuller Pace, F.V. (1998) Expression of the 'dead box' RNA helicase p68 is developmentally and growth regulated and correlates with organ differentiation/maturation in the fetus. J. Pathol, 184, 351-359
10. Ip, F.C, Chung, S.S., Vu, W.Y. and Ip, N.Y. (2000) Developmental and tissue-specific expression of DEAD box protein p72. Neuroreport 11, 457-462
11. Kahlina, K., Goren, I., Pfeilschifter, J. and Frank, S. (2004) p68 DEAD box RNA helicase expression in keratinocytes: regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression. J. Biol. Chem. 279, 44872-44882
12. Kitamura, A., Nishizuka, M., Tominaga, K., Tsuchiya, T., Nishihara, T. and Imagawa, M. (2001) Expression of p68 RNA helicase is closely related to the early stage of adipocyte differentiation of mouse 3T3-L1 cells. Biochem. Biophys. Res. Commun. 287, 435-439
13. Caretti, G., Schiltz, R.L., Dilworth, F.J., Di Padova, M., Zhao, P., Ogryzko, V., Fuller-Pace, F.V., Hoffman, E.P., Tapscoll, S.J. and Sartorelli, V. (2006) The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev. Cell 11, 547-560
14. Neubauer, G., King, A., Rappsilber, J., Calvio, C., Watson, M., Ajuh, P., Sleeman, J., Lamond, A. and Mann, M. (1998) Mass spectrometry and EST-database searching allows characterisation of the multi-protein spliceosome complex. Nat. Genet. 20, 46-50
15. Liu, Z.R. (2002) p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5′ splice site duplex. Mol. Cell. Biol. 22, 5443-5450
16. Lee, C.G. (2002) RH70, a bidirectional RNA helicase, co-purifies with U1 snRNP. J. Biol. Chem. 277, 39679-39683
17. Endoh, H., Maruyama, K., Masuhiro, Y., Kobayashi, Y., Goto, M., Tai, H., Yanagisawa, J., Metzger, D., Hashimoto, S. and Kato, S. (1999) Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor α. Mol. Cell. Biol. 19, 5363-5372
18. Watanabe, M., Yanagisawa, J., Kitagawa, H., Takeyama, K., Ogawa, S., Arao, Y., Suzawa, M., Kobayashi, Y., Yano, T., Yoshikawa, H. et al. (2001) A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor α coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J. 20, 1341-1352
19. Wilson, B.J., Bates, G.J., Nicol, S.M., Gregory, D.J., Perkins, N.D. and Fuller-Pace, F.V. (2004) The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC Mol. Biol. 5, 11
20. Metivier, R., Penot, G., Hubner, M.R., Reid, G., Brand, H., Kos, M. and Gannon, F. (2003) Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751-763
21. Bates, G.J., Nicol, S.M., Wilson, B.J., Jacobs, A.M., Bourdon, J.C., Wardrop, J., Gregory, D.J., Lane, D.P., Perkins, N.D. and Fuller-Pace, F.V. (2005) The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. EMBO J. 24, 543-553
22. Caretti, G., Lei, E.P. and Sartorelli, V. (2007) The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions. Cell Cycle 6, 1172-1176
23. Rossow, K.L. and Janknecht, R. (2003) Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. Oncogene 22, 151-156
24. Jensen, E.D., Niu, L., Caretti, G., Nicol, S.M., Teplyuk, N., Stein, G.S., Sartorelli, V., van Wijnen, A.J., Fuller-Pace, F.V. and Westendorf, J.J. (2008) p68 (DdxS) interacts with Runx2 and regulates osteoblast differentiation. J. Cell. Biochem. 103, 1438-1451
25. Buszczak, M. and Spradling, A.C. (2006) The Drosophila p68 RNA helicase regulates transcriptional deactivation by promoting RNA release from chromatin. Genes Dev. 20, 977-989
26. Auboeuf, D., Honig, A., Berget, S.M. and O'Malley, B.W. (2002) Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science 298, 416-419
27. Guil, S., Gattoni, R., Carrascal, M., Abian, J., Stevenin, J. and Bach-Elias, M. (2003) Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ros alternative splicing regulation. Mol. Cell. Biol. 23, 2927-2941
28. Bond, A.T., Mangus, D.A., He, F. and Jacobson, A. (2001) Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing. Mol. Cell. Biol. 21, 7366-7379
29. Jalal, C., Uhlmann-Schiffler, H. and Stahl, H. (2007) Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation. Nucleic Acids Res. 35, 3590-3601
30. Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T. et al. (2007) DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat. Cell Biol. 9, 604-611
31. Proudfoot, N.J., Furger, A. and Dye, M.J. (2002) Integrating mRNA processing with transcription. Cell 108, 501-512
32. Auboeuf, D., Dowhan, D.H., Dutertre, M., Martin, N., Berget, S.M. and O'Malley, B.W. (2005) A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts. Mol. Cell. Biol. 25, 5307-5316
33. Causevic, M., Hislop, R.G., Kernohan, N.M., Carey, F.A., Kay, R.A., Steele, R.J. and Fuller-Pace, F.V. (2001) overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours. Oncogene 20, 7734-7743
34. Shin, S., Rossow, K.L., Grande, J.P. and Janknecht, R. (2007) Involvement of RNA helicases p68 and p72 in colon cancer. Cancer Res. 67, 7572-7578
35. Yang, L., Lin, C. and Liu, Z.R. (2006) p68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing axin from β-catenin. Cell 127, 139-155