Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expression

Toxicological Sciences

Volumn 121, Issue 1, 2011, Pages 101-109

  Huang, Huei Sheng ^a   Liu, Zi Miao ^a   Cheng, Ya Ling ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

ATO; c jun; GSK 3 ; p21

Indexed keywords

ARSENIC TRIOXIDE; CYCLOHEXIMIDE; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P21;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; DEPHOSPHORYLATION; DNA BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KERATINOCYTE; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; TRANSCRIPTION INITIATION; ULTRAVIOLET RADIATION;

EID: 79955429081     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr023     Document Type: Article

References (45)

1. Blaine, S. A., Wick, M., Dessev, C., and Nemenoff, R. A. (2001). Induction of cPLA2 in lung epithelial cells and non-small cell lung cancer is mediated by Sp1 and c-Jun. J. Biol. Chem. 276, 42737-42743.
2. Bode, A. M., and Dong, Y. (2002). The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects. Crit. Rev. Oncol. Hematol. 42, 5-24.
3. Boyle, W. J., Smeal, T., Defize, L. H., Angel, P., Woodgett, J. R., Karin, M., and Hunter, T. (1991). Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64, 574-584.
4. Cao, Q., Lu, X., and Feng, Y. J. (2006). Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells. Cell Res. 16, 671-677.
5. Chen, B. K., and Chang, W. C. (2000). Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase. Proc. Natl. Acad. Sci. U.S.A. 97, 10406-10411.
6. Chen, B. K., Huang, C. C., Chang, W. C., Chen, Y. J., Kikkawa, U., Nakahama, K., and Morita, I. (2007). PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells. Mol. Biol. Cell 18, 1118-1127.
7. Cohen, P., and Frame, S. (2001). The renaissance of GSK-3. Nat. Rev. Mol. Cell Biol. 2, 769-776.
8. Dilda, P. J., and Hogg, P. J. (2007). Arsenical-based cancer drugs. Cancer Treat. Rev. 33, 542-564.
9. Ding, Q., Xia, W., Liu, J. C., Yang, J. Y., Lee, D. F., Xia, J., Bartholomeusz, G., Li, Y., Pan, Y., Li, Z., et al. (2005). Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol. Cell 19, 159-170.
10. Doble, B. W., and Woodgett, J. R. (2003). GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116, 1175-1186.
11. Efferth, T., Li, P. C., Konkimalla, V. S., and Kaina, B. (2007). From traditional Chinese medicine to rational cancer therapy. Trends Mol. Med. 13, 353-361.
12. Embi, N., Rylatt, D. B., and Cohen, P. (1980). Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur. J. Biochem. 107, 519-527.
13. Farago, M., Dominguez, I., Landesman-Bollag, E., Xu, X., Rosner, A., Cardiff, R. D., and Seldin, D. C. (2005). Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis. Cancer Res. 65, 5792-5801.
14. Forde, J. E., and Dale, T. C. (2007). Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol. Life Sci. 64, 1930-1944.
15. WAF1/CIP1 gene. Exp. Cell Res. 246, 280-289.
16. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclindependent kinases. Cell 75, 805-816.
17. WAF1/CIP1 activation involved in the arsenic trioxideinduced human epidermoid carcinoma A431 cellular cytotoxicity. J. Biomed. Sci. 13, 113-125.
18. Huang, C. C., Wang, J. M., Kikkawa, U., Mukai, H., Shen, M. R., Morita, I., Chen, B. K., and Chang, W. C. (2008). Calcineurin-mediated dephosphorylation of c-Jun Ser243 is required for c-Jun protein stability and cell transformation. Oncogene 27, 2422-2429.
19. Huang, H. S., Liu, Z. M., and Hong, D. Y. (2010). Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. Toxicol. Appl. Pharmacol. 244, 234-241.
20. Hung, J. J., Wang, Y. T., and Chang, W. C. (2006). Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. Mol. Cell Biol. 26, 1770-1785.
21. Jope, R. S. (2003). Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol. Sci. 24, 441-443.
22. Kardassis, D., Papakosta, P., Pardali, K., and Moustakas, A. (1999). c-Jun transactivates the promoter of the human p21WAF1/Cip1 gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J. Biol. Chem. 274, 29572-29581.
23. Karin, M., Liu, Z., and Zandi, E. (1997). AP-1 function and regulation. Curr. Opin. Cell Biol. 9, 240-246.
24. Klee, C. B., Ren, H., and Wang, X. (1998). Regulation of the calmodulinstimulated protein phosphatase, calcineurin. J. Biol. Chem. 273, 13367-13370.
25. Lee, J. Y., Yu, S. J., Park, Y. G., Kim, J., and Sohn, J. (2007). Glycogen synthase kinase 3beta phosphorylates p21WAF1/Cip1 for proteasomal degradation after UV irradiation. Mol. Cell Biol. 27, 3187-3198.
26. Lin, A., Frost, J., Deng, T., Smeal, T., al-Alawi, N., Kikkawa, U., Hunter, T., Brenner, D., and Karin, M. (1992). Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70, 777-789.
27. WAF1/Cip1 expression in human epidermoid carcinoma A431 cells. Cell Signal. 18, 244-255.
28. WAF1/Cip1 expression. Toxicol. Appl. Pharmacol. 233, 297-307.
29. WAF1/CIP1 expression. J. Biomed. Sci. 15, 333-342.
30. Miller, W. H., Jr., Schipper, H. M., Lee, J. S., Singer, J., and Waxman, S. (2002). Mechanisms of action of arsenic trioxide. Cancer Res. 62, 3893-3903.
31. Morton, S., Davis, R. J., McLaren, A., and Cohen, P. (2003). A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. EMBO J. 22, 3876-3886.
32. Ougolkov, A. V., Fernandez-Zapico, M. E., Savoy, D. N., Urrutia, R. A., and Billadeau, D. D. (2005). Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res. 65, 2076-2081.
33. Papavassiliou, A. G., Treier, M., and Bohmann, D. (1995). Intramolecular signal transduction in c-Jun. EMBO J. 14, 2014-2019.
34. Platanias, L. C. (2009). Biological responses to arsenic compounds. J. Biol. Chem. 284, 18583-18587.
35. Raivich, G. (2008). c-Jun expression, activation and function in neural cell death, inflammation and repair. J. Neurochem. 107, 898-906.
36. Rayasam, G. V., Tulasi, V. K., Sodhi, R., Davis, J. A., and Ray, A. (2009). Glycogen synthase kinase 3: more than a namesake. Br. J. Pharmacol. 156, 885-898.
37. Rossig, L., Badorff, C., Holzmann, Y., Zeiher, A. M., and Dimmeler, S. (2002). Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J. Biol. Chem. 277, 9684-9689.
38. Shakoori, A., Ougolkov, A., Yu, Z. W., Zhang, B., Modarressi, M. H., Billadeau, D. D., Mai, M., Takahashi, Y., and Minamoto, T. (2005). Deregulated GSK-3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem. Biophys. Res. Commun. 334, 1365-1373.
39. Shaulian, E., and Karin, M. (2002). AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4, E131-E136.
40. Shaulian, E. (2010). AP-1-The Jun proteins: oncogenes or tumor suppressors in disguise? Cell Signal. 22, 894-899.
41. Sherr, C. J., and Roberts, J. M. (1999). CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512.
42. Wang, Y. N., and Chang, W. C. (2003). Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun. J. Biol. Chem. 278, 45848-45857.
43. Wang, Y., Lam, J. B., Lam, K. S., Liu, J., Lam, M. C., Hoo, R. L., Wu, D., Cooper, G. J., and Xu, A. (2006). Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res. 66, 11462-11470.
44. Wei, W., Jin, J., Schlisio, S., Harper, J. W., and Kaelin, W. G., Jr. (2005). The v-Jun point mutation allows c-Jun to escape GSK-3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 8, 25-33.
45. Woodgett, J. R. (1990). Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J. 9, 2431-2438.